As of September 2020, there are approximately 1800 pharma companies. The total value of global pharma sector has tripled in the last 17 years from $1.99 in 2003 to $6.65 trillion in 2020. The industry value CAGR since 2003 has been 7.4%.

Evolution of the pharma sector suggests Big Pharma sector grew slowly between 2015 to 2020, losing 5% in value share. In contrast, animal health and biotech sectors grew substantially in the same period.

In terms of specific drug modality, Biologics companies grew as a group by $1.1 trillion in just 5 years. Other big growth areas were vaccines, nucleic acids, peptides, cell therapy and gene therapy.

Considering country level evolution of Pharma industry, most countries have seen a rise, but none has seen an increase more than China which added over $500 billion in value over the last five years. In U.S. there has been an increase if 22% in the last five years.

The bar to be in the Pharma 1000 list has moved up gradually over time though. A company would need to have had a valuation of at least $336 million to be in the top 1000.

See the full list of Top 1000 Pharmaceutical Companies below.


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  • The Global Pharmaceutical Industry
  • Rapid Growth of Biotech Sector
  • The Evolving Branded Pharma Sector
  • The Generic Pharma Sector
  • Top 1000 Companies by Value
  • Profiles of the Top 500 Companies


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List of Top 1000 Pharmaceutical Companies by Value

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Value

Name

Headquarters

Value Estimate

Revenue

Rank  Location (Sep 2020) (Trailing)
2020
1 Roche Basel, Switzerland $328 bn $49 bn
2 Janssen (J&J) Raritan, NJ, US $279 bn $42 bn
3 Pfizer New York Area, US $257 bn $49 bn
4 AbbVie Chicago Area $242 bn $36 bn
5 Merck New York Area, US $233 bn $47 bn
6 Novartis Basel, Switzerland $210 bn $49 bn
7 Amgen Thousand Oaks, CA, US $164 bn $24 bn
8 AstraZeneca Boston Area, US $162 bn $25 bn
9 Bristol-Myers Squibb New York Area, US $158 bn $34 bn
10 Novo Nordisk Copenhagen, Denmark $155 bn $19 bn
11 Eli Lilly Indiana, US $151 bn $22 bn
12 Boehringer Ingelheim Ingelheim, Germany $148 bn $22 bn
13 GlaxoSmithKline London, United Kingdom $136 bn $43 bn
14 Bayer Leverkusen, Germany $133 bn $20 bn
15 Sanofi Paris, France $120 bn $42 bn
16 Takeda Tokyo Japan $104 bn $30 bn
17 CSL Parkville, Australia $100 bn $9 bn
18 Gilead Bay Area, US $87 bn $22 bn
19 Zoetis New York Area, US $82 bn $6.3 bn
20 Chugai Tokyo, Japan $72 bn $6.8 bn
21 Hengrui Medicine Jiangsu Province, China $69 bn $3.4 bn
22 Vertex Pharma Boston Area, US $65 bn $5.4 bn
23 Regeneron New York Area, US $58 bn $8.6 bn
24 Daiichi Sankyo Tokyo, Japan $54 bn $8.9 bn
25 Merck KGaA Pharma Berlin, Germany $50 bn $7.5 bn
26 Biogen Boston Area, US $48 bn $14 bn
27 Yangtze River Pharma Jiangsu Province, China $44 bn $12 bn
28 Servier Paris, France $36 bn $5.4 bn
29 Teva Israel $35 bn $16 bn
30 Celltrion South Korea $33 bn $1.2 bn
31 CSPC Pharma Hebei Province, China $33 bn $5 bn
32 Zhifei Bio Sichuan Province, China $31 bn $1.7 bn
33 Seattle Genetics Seattle, US $30 bn $1 bn
34 Menarini Florence, Italy $30 bn $4.4 bn
35 Bausch Health New York Area, US $29 bn $8.1 bn
36 Royalty Pharma New York Area, US $29 bn $1.9 bn
37 Hansoh Pharma Lianyungang, China $26 bn $1.1 bn
38 Astellas Tokyo, Japan $26 bn $11 bn
39 Grifols Barcelona, Spain $26 bn $6 bn
40 Alexion New York Area, US $25 bn $5.5 bn
41 Eisai Tokyo, Japan $24 bn $6.5 bn
42 Moderna Boston Area, US $24 bn $105 mn
43 Qilu Pharma Shandong Province, China $24 bn $3.6 bn
44 UCB Brussels, Belgium $24 bn $5.8 bn
45 Sino Biopharma Hong Kong $23 bn $3.4 bn
46 Changchun Tech Jilin Province, China $23 bn $1.1 bn
47 Genmab Copenhagen, Denmark $22 bn $1.5 bn
48 Otsuka Tokyo, Japan $22 bn $13 bn
49 Pientzehuang Pharma Fujian Province, China $22 bn $859 mn
50 Kelun Group Sichuan Province, China $22 bn $6 bn
51 Galderma La Tour-de-Peilz, Switzerland $20 bn $3 bn
52 BeiGene Beijing, China $20 bn $224 mn
53 Mylan Pittsburgh Area, US $20 bn $11 bn
54 Jemincare Jianxi Province, China $19.3 bn $5.3 bn
55 Pierre Fabre Paris, France $18.7 bn $2.8 bn
56 Immunomedics New York Area, US $18.6 bn $20 mn
57 Incyte Philadelphia Area, US $18.5 bn $2.3 bn
58 Horizon Therapeutics Chicago Area $17.9 bn $1.5 bn
59 Yunnan Baiyao Yunnan Province, China $17.6 bn $4.4 bn
60 Kangtai Bio Guangdong Province, China $17.3 bn $283 mn
61 Octapharma Lachen, Switzerland $17.1 bn $2.5 bn
62 Fosun Pharma Shanghai, China $16.7 bn $4 bn
63 Ferring Geneva, Switzerland $16.7 bn $2.5 bn
64 Sun Pharma Mumbai, India $16.4 bn $4.2 bn
65 Abbott EPD Chicago Area $16.1 bn $4.4 bn
66 Chiesi Parma, Italy $15.5 bn $2.3 bn
67 BioNTech Mainz, Germany $15.4 bn $141 mn
68 Ono Osaka, Japan $14.7 bn $2.7 bn
69 BioMarin Bay Area, US $13.8 bn $1.8 bn
70 Alnylam Boston Area, US $13.5 bn $345 mn
71 Elanco Indiana, US $13.4 bn $2.8 bn
72 Shionogi Osaka, Japan $13.3 bn $3 bn
73 Mundipharma New York Area, US $13.2 bn $2 bn
74 Hualan Bio Henan Province, China $13.1 bn $521 mn
75 NC Pharma / EMS Hortolandia, Brazil $12.8 bn $1.9 bn
76 Fresenius Kabi Segment Hessen, Germany $12.5 bn $3.4 bn
77 Walvax Yunnan Province, China $12.5 bn $169 mn
78 Samumed San Diego, CA $12.4 bn NA
79 Kyowa Kirin Tokyo, Japan $12.2 bn $2.8 bn
80 Recordati Milan, Italy $12.2 bn $1.6 bn
81 Shanghai Pharma – Mfg Shanghai, China $12.1 bn $3.3 bn
82 Tianjin Pharma Tianjin, China $12 bn $3.3 bn
83 R-Pharm Moscow, Russia $11.9 bn $1.8 bn
84 Grupo Insud Madrid, Spain $11.7 bn $1.7 bn
85 Adimab Lebanon, NH, US $11.4 bn NA
86 LEO Pharma Copenhagen, Denmark $11.4 bn $1.7 bn
87 SK Biopharma Seoul, Korea $11 bn $5.2 mn
88 Grunenthal Aachen, Germany $10.9 bn $1.6 bn
89 Roemmers Argentina $10.8 bn $3 bn
90 Innovent Biologics Jiangsu Province, China $10.5 bn $238 mn
91 Vifor Pharma St. Gallen, Switzerland $10.2 bn $2 bn
92 Bracco Milan, Italy $10.1 bn $1.5 bn
93 Dr. Reddy’s Hyderabad, India $10.1 bn $2.3 bn
94 Junshi Biosciences Jiangsu Province, China $10 bn $147 mn
95 Ibsen Paris, France $10 bn $3 bn
96 Roivant Sciences New York Area, US $10 bn NA
97 Sarepta Therapeutics Boston Area, US $9.9 bn $450 mn
98 Harbin Pharma Heilongjiang Province, China $9.7 bn $2.7 bn
99 CureVac Tubingen, Germany $9.6 bn $19 mn
100 Ceva Sante Animale Dusseldorf, Germany $9.3 bn $1.4 bn
101 Neurocrine Biosciences San Diego, US $9.3 bn $1 bn
102 Gan & Lee Pharma Beijing, China $9.3 bn $445 mn
103 argenx Netherlands $8.8 bn $70 mn
104 Humanwell Healthcare Hubei Province, China $8.8 bn $2.9 bn
105 Sobi Sweden $8.7 bn $1.6 bn
106 CR Pharma Rx Segment Hong Kong $8.6 bn $4.3 bn
107 Hetero Drugs Hyderabad, India $8.6 bn $2.3 bn
108 Merz Hessen, Germany $8.5 bn $1.2 bn
109 Hikma London, United Kingdom $8.4 bn $2.2 bn
110 Kangmei Pharma Guangdong Province, China $8.4 bn $825 mn
111 Jazz Pharma Bay Area, US $8.4 bn $2.2 bn
112 Huahai Pharma Zhejiang Province, China $8.4 bn $855 mn
113 Cipla Mumbai, India $8.3 bn $2.3 bn
114 Serum Institute of India Pune, India $8.3 bn $819 mn
115 Baxter Pharma Chicago Area $8.2 bn $2.2 bn
116 Shanghai RAAS Shanghai, China $8.2 bn $367 mn
117 CanSino Biologics Tianjin, China $8.2 bn $2.2 mn
118 Alfasigma Florence, Italy $8.2 bn $1.2 bn
119 Mitsubishi Tanabe Osaka, Japan $8 bn $3.8 bn
120 Lundbeck Copenhagen, Denmark $7.8 bn $2.6 bn
121 Tiantan Biological Beijing, China $7.5 bn $463 mn
122 Endo International New York Area, US $7.3 bn $3 bn
123 Biocon Bangalore, India $7.3 bn $871 mn
124 Torrent Pharma Ahmedabad, India $7.3 bn $1 bn
125 Apotex Toronto Area, Canada $7.3 bn $2 bn
126 STADA Bad Vilbel, Germany $7.2 bn $3.1 bn
127 Ascendis Pharma Copenhagen, Denmark $7.1 bn $9.4 mn
128 Santen Osaka, Japan $7.1 bn $2.2 bn
129 Angelini Rome, Italy $7 bn $1 bn
130 Schwabe Stutensee, Germany $7 bn $1 bn
131 Aurobindo Hyderabad, India $6.9 bn $3.1 bn
132 Betta Pharm Zhejiang Province, China $6.8 bn $246 mn
133 Intas Pharma Ahmedabad, India $6.6 bn $1.8 bn
134 Exelixis Bay Area, US $6.6 bn $998 mn
135 Ache Laboratorios Guarulhos, Brazil $6.6 bn $1 bn
136 Unilab Philippines $6.6 bn $1 bn
137 Dainippon Sumitomo Osaka, Japan $6.6 bn $4.6 bn
138 Orion Finland $6.5 bn $1.2 bn
139 Lupin Mumbai, India $6.4 bn $1.9 bn
140 Huadong Medicine Zhejiang Province, China $6.4 bn $4.7 bn
141 Mirati Therapeutics San Diego, US $6.4 bn $1.7 mn
142 Zydus Cadila Ahmedabad, India $6.3 bn $1.9 bn
143 Kedrion Florence, Italy $6.3 bn $953 mn
144 King-Friend Bio Jiangsu Province, China $6.2 bn $380 mn
145 Shin Poong South Korea $6.2 bn $164 mn
146 lonis San Diego, US $6.1 bn $940 mn
147 Emergent BioSolutions Gaithersburg, MD, US $6 bn $1.2 bn
148 Green Valley Pharma Shanghai, China $5.9 bn $900 mn
149 Guangzhou Pharma Guangdong Province, China $5.9 bn $8.7 bn
150 MyoKardia Bay Area, US $5.9 bn NA
151 Momenta Boston Area, US $5.8 bn $30 mn
152 Kanghong Pharma Sichuan Province, China $5.8 bn $443 mn
153 Acceleron Boston Area, US $5.7 bn $87 mn
154 Novavax Gaithersburg, MD, US $5.7 bn $50 mn
155 Aspen Pharmacare South Africa $5.7 bn $2.2 bn
156 Italfarmaco Milan, Italy $5.7 bn $856 mn
157 Zambon Milan, Italy $5.6 bn $853 mn
158 Maruho Osaka, Japan $5.6 bn $847 mn
159 ACADIA Pharma San Diego, US $5.5 bn $393 mn
160 Zai Lab Shanghai China $5.5 bn $28 mn
161 Youcare Pharma Beijing, China $5.4 bn $1.5 bn
162 Salubris Pharma Guangdong Province, China $5.4 bn $516 mn
163 Nippon Shinyaku Tokyo, Japan $5.2 bn $1.1 bn
164 Grupo Ferrer Barcelona, Spain $5.2 bn $790 mn
165 Yifan Pharma Zhejiang Province, China $5.1 bn $775 mn
166 CRISPR Therapeutics Zug, Switzerland $5.1 bn $289 mn
167 PeptiDream Kawasaki, Japan $5.1 bn $0 mn
168 Livzon Guangdong Province, China $5 bn $1.3 bn
169 ALTEOGEN South Korea $5 bn $36 mn
170 Tasly Pharma Tianjin, China $5 bn $2.5 bn
171 Alkem Mumbai, India $4.8 bn $1.1 bn
172 Kalbe North Sumatra, Indonesia $4.8 bn $1.5 bn
173 Dechra Pharma Northern UK $4.7 bn $637 mn
174 Mallinckrodt London, United Kingdom $4.5 bn $2.3 bn
175 Chi-Med Hong Kong $4.5 bn $209 mn
176 Laboratoires Thea Clermont-Ferrand, France $4.5 bn $678 mn
177 lovance Bay Area, US $4.5 bn NA
178 Samsung Bioepis South Korea $4.4 bn $850 mn
179 Wolwo Pharma Zhejiang Province, China $4.4 bn $88 mn
180 Dongbao Pharma Jilin Province, China $4.4 bn $398 mn
181 Buchang Pharma Shandong Province, China $4.4 bn $2.1 bn
182 Mega Pharma Uruguay $4.3 bn $1.2 bn
183 Kanghua Biological Sichuan Province, China $4.3 bn $104 mn
184 Yiling Pharma Hebei Province, China $4.3 bn $1 bn
185 NCPC Hebei Province, China $4.3 bn $1.5 bn
186 Abdi Ibrahim Turkey $4.2 bn $639 mn
187 Jinyu Bio-Tech Mongolia $4.2 bn $175 mn
188 CHEPLAPHARM Pomerania, Germany $4.2 bn $1.1 bn
189 Ultragenyx Bay Area, US $4.2 bn $159 mn
190 Allogene Bay Area, US $4.1 bn NA
191 Meiji Pharma Business Tokyo, Japan $4.1 bn $1.9 bn
192 Orifarm Copenhagen, Denmark $4 bn $1.1 bn
193 Pharmstandard Dolgoprudny, Russia $4 bn $1.1 bn
194 Grupo Bago Argentina $4 bn $1.1 bn
195 Apeloa Pharma Zhejiang Province, China $4 bn $1 bn
196 Polpharma Poland $3.9 bn $1 bn
197 Idorsia Basel, Switzerland $3.9 bn $72 mn
198 Oneness Biotech Taiwan $3.9 bn $1.4 mn
199 Hisun Pharma Zhejiang Province, China $3.8 bn $1.5 bn
200 Halozyme San Diego, US $3.8 bn $180 mn
201 IBSA Lugano, Switzerland $3.8 bn $572 mn
202 Celltrion Pharm South Korea $3.7 bn $152 mn
203 neuraxpharm Langenfeld, Germany $3.7 bn $566 mn
204 Hypera Sao Paolo, Brazil $3.7 bn $694 mn
205 Ipca Mumbai, India $3.7 bn $617 mn
206 Esteve Barcelona, Spain $3.7 bn $556 mn
207 Biohaven New York Area, US $3.7 bn $10 mn
208 Haisco Sichuan Province, China $3.7 bn $498 mn
209 Gedeon Richter Hungary $3.6 bn $1.7 bn
210 Relay Therapeutics Boston Area, US $3.6 bn $0 mn
211 Legend Biotech Jiangsu Province, China $3.6 bn $61 mn
212 Hanmi Pharm South Korea $3.6 bn $917 mn
213 Barakat Pharmaceutical Iran $3.6 bn $1 bn
214 Blueprint Medicines Boston Area, US $3.6 bn $75 mn
215 Allakos Bay Area, US $3.6 bn NA
216 ALK Copenhagen, Denmark $3.6 bn $505 mn
217 LG Life Sciences South Korea $3.6 bn $540 mn
218 JCR Ashiya, Japan $3.5 bn $230 mn
219 Eurofarma Sao Paolo, Brazil $3.5 bn $982 mn
220 Genexine South Korea $3.5 bn $4.1 mn
221 ROHTO Osaka, Japan $3.5 bn $1.7 bn
222 Besins Monaco $3.5 bn $531 mn
223 Amicus Therapeutics New York Area, US $3.5 bn $226 mn
224 Perrigo Rx Business Allegan, MI, US $3.5 bn $968 mn
225 Denali Therapeutics Bay Area, US $3.5 bn $27 mn
226 Kyoritsu Seiyaku Tokyo, Japan $3.5 bn $524 mn
227 Zentiva Czech Republic $3.4 bn $957 mn
228 Genus London, United Kingdom $3.4 bn $682 mn
229 Amneal New York Area, US $3.4 bn $1.7 bn
230 China Grand Pharma Hong Kong $3.4 bn $807 mn
231 FibroGen Bay Area, US $3.4 bn $108 mn
232 Vir Biotechnology Bay Area, US $3.4 bn $75 mn
233 Dermapharm Munich Area, Germany $3.4 bn $855 mn
234 Schrodinger Bangalore, India $3.4 bn $95 mn
235 Dompe Milan, Italy $3.3 bn $507 mn
236 Luoxin Pharma Shandong Province, China $3.3 bn $897 mn
237 MorphoSys Munich Area, Germany $3.3 bn $329 mn
238 Shafadarou Investment Iran $3.3 bn $906 mn
239 Norgine Netherlands $3.3 bn $494 mn
240 AnkeBio Anhui Province, China $3.3 bn $235 mn
241 Yuhan South Korea $3.2 bn $1.2 bn
242 Macleods Pharma Mumbai, India $3.2 bn $891 mn
243 PROBIOMED Mexico $3.2 bn $317 mn
244 Dr. Falk Pharma Freiburg im Breisgau, Germany $3.2 bn $485 mn
245 ChemoCentryx Bay Area, US $3.2 bn $76 mn
246 Arrowhead Pharma Los Angeles, US $3.2 bn $123 mn
247 Taisho Pharma Tokyo, Japan $3.2 bn $2.8 bn
248 Pars Darou Iran $3.2 bn $881 mn
249 China Meheco Group Beijing, China $3.2 bn $5.2 bn
250 China Biologic Products Beijing, China $3.1 bn $511 mn
251 Bridgebio Pharma Bay Area, US $3.1 bn $40 mn
252 LFB Paris, France $3.1 bn $472 mn
253 PTC Therapeutics New York Area, US $3.1 bn $311 mn
254 Immunovant New York Area, US $3.1 bn NA
255 lnsmed New York Area, US $3.1 bn $163 mn
256 Asahi Kasei Pharma Tokyo, Japan $3.1 bn NA
257 GC Pharma South Korea $3 bn $1.1 bn
258 BrightGene Bio Jiangsu Province, China $3 bn $84 mn
259 medac gmbh Wedel, Germany $2.9 bn $446 mn
260 3SBio Liaoning Province, China $2.9 bn $760 mn
261 Amoytop Biotech Fujian Province, China $2.9 bn $109 mn
262 United Therapeutics Silver Spring MD, US $2.9 bn $1.4 bn
263 GBT Bay Area, US $2.9 bn $47 mn
264 GW Pharmaceuticals Cambridge, UK $2.9 bn $441 mn
265 Arena Pharma San Diego, US $2.9 bn $4.6 mn
266 Alvogen New York Area, US $2.9 bn $800 mn
267 Prasco Mason, Ohio, US $2.9 bn $800 mn
268 Simcere Pharma Jiangsu Province, China $2.9 bn $800 mn
269 ADC Therapeutics Geneva, Switzerland $2.9 bn $0 mn
270 Axsome New York, NY $2.9 bn NA
271 BIOCAD St. Petersburg, Russia $2.9 bn $283 mn
272 Guojian Pharma Shanghai, China $2.8 bn $149 mn
273 KrKa Slovenia $2.8 bn $1.7 bn
274 Chipscreen Guangdong Province, China $2.8 bn $28 mn
275 Harmony Biosciences Philadelphia Area, US $2.8 bn $63 mn
276 Fate Therapeutics San Diego, US $2.8 bn $13 mn
277 Reata Pharma Irving, TX, US $2.8 bn $13 mn
278 Hisamitsu Tosu, Japan $2.8 bn $1.2 bn
279 China Medical System Guangdong Province, China $2.8 bn $880 mn
280 Biolab Sanus Pharma Sao Paolo, Brazil $2.8 bn $418 mn
281 Biolab Sanus Pharma Sao Paolo, Brazil $2.8 bn $418 mn
282 Mankind Pharma Delhi, India $2.8 bn $766 mn
283 Sawai Osaka, Japan $2.7 bn $1.6 bn
284 Jubilant Pharma Segment Noida, UP, India $2.7 bn $758 mn
285 TG Therapeutics New York Area, US $2.7 bn $0.1 mn
286 Ethypharm Paris, France $2.7 bn $413 mn
287 China TCM Holdings Hong Kong $2.7 bn $1.9 bn
288 Kowa Pharma Segment Tokyo, Japan $2.7 bn $1.3 bn
289 Alembic Ahmedabad, India $2.7 bn $661 mn
290 Alkermes Boston Area, US $2.7 bn $1.1 bn
291 Nektar Bay Area, US $2.7 bn $162 mn
292 Neopharm Ltd Israel $2.6 bn $400 mn
293 AoDong Medicine Jilin Province, China $2.6 bn $363 mn
294 Chase Sun Pharma Tianjin, China $2.6 bn $778 mn
295 Akeso Guangdong Province, China $2.6 bn $10 mn
296 Joincare Pharma Guangdong Province, China $2.6 bn $1.7 bn
297 Turning Point San Diego, US $2.6 bn NA
298 Pacira New York Area, US $2.6 bn $408 mn
299 Dendreon / Sanpower Los Angeles, US $2.6 bn $393 mn
300 Bio-Thera Solutions Guangdong Province, China $2.6 bn $7 mn
301 Zelgen Bio Anhui Province, China $2.6 bn NA
302 Jumpcan Pharma Jiangsu Province, China $2.6 bn $847 mn
303 Luye Pharma Shandong Province, China $2.5 bn $876 mn
304 Shuanglin Biopharma Guangdong Province, China $2.5 bn $133 mn
305 Pharmascience Quebec, Canada $2.5 bn $700 mn
306 Almirall Barcelona, Spain $2.5 bn $981 mn
307 Karo Pharma Sweden $2.5 bn $276 mn
308 Ocumension Jiangsu Province, China $2.5 bn $0.3 mn
309 Fudan-Zhangjiang Shanghai China $2.5 bn $123 mn
310 Emcure Mumbai, India $2.4 bn $673 mn
311 OPKO Health Miami, Florida, US $2.4 bn $965 mn
312 Seres Therapeutics Boston Area, US $2.4 bn $28 mn
313 Xianju Pharma Zhejiang Province, China $2.4 bn $512 mn
314 Tsumura Osaka, Japan $2.4 bn $1.1 bn
315 Boya Bio Jiangxi Province, China $2.4 bn $404 mn
316 Galapagos Belgium $2.4 bn $1.1 bn
317 Teijin Pharma Tokyo, Japan $2.3 bn $1.1 bn
318 Fidia Farma Abano Terme, Italy $2.3 bn $354 mn
319 Glenmark Mumbai, India $2.3 bn $1.4 bn
320 CytoDyn Seattle, US $2.3 bn NA
321 Sage Therapeutics Boston Area, US $2.3 bn $8.9 mn
322 Biocodex Paris, France $2.3 bn $350 mn
323 Helsinn Lugano, Switzerland $2.3 bn $350 mn
324 Deciphera Boston Area, US $2.3 bn $7.1 mn
325 Virbac Carros, France $2.3 bn $1 bn
326 Conba Pharma Zhejiang Province, China $2.3 bn $893 mn
327 BIAL Portugal $2.3 bn $345 mn
328 Zhejiang Medicine Zhejiang Province, China $2.3 bn $989 mn
329 Adamed Poland $2.3 bn $343 mn
330 ASK Pharm Jiangsu Province, China $2.2 bn $526 mn
331 Hile Bio-Technology Shanghai, China $2.2 bn $36 mn
332 China Animal Husbandry Beijing, China $2.2 bn $644 mn
333 bluebird bio Boston Area, US $2.2 bn $239 mn
334 Liomont Mexico $2.2 bn $600 mn
335 Stallergenes Greer London, United Kingdom $2.2 bn $326 mn
336 Haiyao Hainan Province, China $2.1 bn $298 mn
337 Bailing Group Pharma Guizhou, China $2.1 bn $393 mn
338 Aristo Pharma Berlin, Germany $2.1 bn $590 mn
339 Nhwa Pharma Jiangsu Province, China $2.1 bn $500 mn
340 Huvepharma Bulgaria $2.1 bn $320 mn
341 PharmaMar Madrid, Spain $2.1 bn $240 mn
342 Aimmune Therapeutics Bay Area, US $2.1 bn $0.5 mn
343 Xinbang Pharma Guizhou, China $2.1 bn $860 mn
344 Haohai Biotech Shanghai, China $2.1 bn NA
345 Myovant Sciences Bay Area, US $2 bn $33 mn
346 ROVI Madrid, Spain $2 bn $444 mn
347 SSY Group Hong Kong $2 bn $528 mn
348 Norbrook Laboratories Northern Ireland, UK $2 bn $305 mn
349 Intra-Cellular Therapies New York Area, US $2 bn $3 mn
350 lnovio Pharma Philadelphia Area, US $2 bn $2.7 mn
351 Mesoblast Melbourne, Australia $2 bn $32 mn
352 Micro Labs Bangalore, India $2 bn $558 mn
353 Cheezheng Tibetan Med Nyingchi, Tibet, China $2 bn $198 mn
354 Agios Boston Area, US $2 bn $185 mn
355 Kodiak Sciences Palo Alto, CA $1.9 bn NA
356 Taiji Group Sichuan Province, China $1.9 bn $1.5 bn
357 Revance Bay Area, US $1.9 bn $0.4 mn
358 Apellis Pharma Boston Area, US $1.9 bn NA
359 Natco Hyderabad, India $1.9 bn $262 mn
360 MSN Laboratories Hyderabad, India $1.9 bn $520 mn
361 Karuna Therapeutics Boston Area, US $1.9 bn NA
362 Sorrento Therapeutics San Diego, US $1.9 bn $35 mn
363 IGM Biosciences Bay Area, US $1.9 bn NA
364 Shyndec Shanghai, China $1.8 bn $1.7 bn
365 CK Life Sciences Hong Kong $1.8 bn $612 mn
366 Bukwang Pharma South Korea $1.8 bn $142 mn
367 Ironwood Pharma Boston Area, US $1.8 bn $426 mn
368 Advanz Pharma London, United Kingdom $1.8 bn $503 mn
369 Medochemie Cyprus $1.8 bn $500 mn
370 Brilliant Pharma Sichuan Province, China $1.8 bn $500 mn
371 Grupo Uriach Barcelona, Spain $1.8 bn $271 mn
372 Square Pharma Bangladesh $1.8 bn $545 mn
373 Acino Zurich, Switzerland $1.8 bn $495 mn
374 Zhongheng Group Guangxi Province, China $1.8 bn $530 mn
375 Ajanta Pharma Mumbai, India $1.8 bn $350 mn
376 Xencor Los Angeles, US $1.8 bn $70 mn
377 SL Pharm Hainan Province, China $1.7 bn $214 mn
378 Hisoar Pharma Zhejiang Province, China $1.7 bn $356 mn
379 Xiangxue Pharma Guangdong Province, China $1.7 bn $464 mn
380 Eidos Therapeutics Bay Area, US $1.7 bn $26 mn
381 ZBD Pharmaceutical Heilongjiang Province, China $1.7 bn $450 mn
382 IDT Biologika Dessau-Roillau, Germany $1.7 bn $259 mn
383 Siam Bioscience Thailand $1.7 bn $169 mn
384 JT Pharma / Torii Tokyo, Japan $1.7 bn $815 mn
385 Theramex London, United Kingdom $1.7 bn $258 mn
386 HIPRA Spain, Other $1.7 bn $256 mn
387 Zhongsheng Pharma Guangdong Province, China $1.7 bn $284 mn
388 Quantum Hi-Tech Guangdong Province, China $1.7 bn $195 mn
389 Biotest / Creat Group Berlin, Germany $1.7 bn $516 mn
390 Sebela Pharma Atlanta, US $1.7 bn $250 mn
391 Tecnoquimicas Colombia $1.6 bn $458 mn
392 Corcept Therapeutics Bay Area, US $1.6 bn $351 mn
393 SINQI Liaoning Province, China $1.6 bn $74 mn
394 Towa Pharma Osaka, Japan $1.6 bn $1.1 bn
395 Nichi-Iko Toyama, Japan $1.6 bn $1.7 bn
396 Kolmar Medicine Unit South Korea $1.6 bn $567 mn
397 Hugel South Korea $1.6 bn $162 mn
398 Alphamab Oncology Jiangsu Province, China $1.6 bn $1.4 mn
399 Aurinia Pharma Vancouver, Canada $1.6 bn $0.3 mn
400 AnGes Osaka, Japan $1.6 bn $1.5 mn
401 USV Mumbai, India $1.6 bn $446 mn
402 Arkopharma Lyon, France $1.6 bn $241 mn
403 Kimia Farma Sumatera Utara, Indonesia $1.6 bn $662 mn
404 Bavarian Nordic Copenhagen, Denmark $1.6 bn $226 mn
405 Dezhan Healthcare Beijing, China $1.6 bn $221 mn
406 SpringWorks New York Area, US $1.6 bn NA
407 Zixin Pharma Jilin Province, China $1.6 bn $65 mn
408 HanAll Biopharma South Korea $1.6 bn $82 mn
409 Cytokinetics Bay Area, US $1.6 bn $18 mn
410 Gebro Pharma Austria $1.6 bn $236 mn
411 Clinigen Northern UK $1.5 bn $624 mn
412 Revolution Medicines Bay Area, US $1.5 bn $46 mn
413 Isdin Barcelona, Spain $1.5 bn $232 mn
414 Laboratorio Elea Argentina $1.5 bn $232 mn
415 ALX Oncology Bay Area, US $1.5 bn $3.6 mn
416 Forma Therapeutics Boston Area, US $1.5 bn $10 mn
417 FujiFilm Pharma Tokyo, Japan $1.5 bn NA
418 Laboratorios Sanfer Mexico $1.5 bn NA
419 Sanovel Turkey $1.5 bn $227 mn
420 SPIMACO Mosadia, Saudi Arabia $1.5 bn $417 mn
421 Abiogen Pharma Pisa, Italy $1.5 bn $223 mn
422 Akcea Therapeutics Boston Area, US $1.5 bn $336 mn
423 uniQure Netherlands $1.5 bn $5.3 mn
424 Innocare Hong Kong $1.5 bn $0.1 mn
425 Microgen Moscow, Russia $1.5 bn $144 mn
426 Intercept Pharma New York Area, US $1.5 bn $283 mn
427 Zymeworks Vancouver, Canada $1.4 bn $30 mn
428 Sobhan Pharma Iran $1.4 bn $397 mn
429 Viela Bio Gaithersburg, MD, US $1.4 bn $30 mn
430 Bimeda Animal Health Ireland $1.4 bn $216 mn
431 Y-mAbs Therapeutics New York Area, US $1.4 bn NA
432 Northeast Pharma Shenyang Province, China $1.4 bn $1.1 bn
433 Sunflower Pharma Heilongjiang Province, China $1.4 bn $507 mn
434 Biological E. Hyderabad, India $1.4 bn $140 mn
435 Editas Medicine Boston Area, US $1.4 bn $32 mn
436 Cortexyme Bay Area, US $1.4 bn NA
437 Yungjin Pharm South Korea $1.4 bn $147 mn
438 Kymera Boston Area, US $1.4 bn NA
439 Lukang Pharma Shandong Province, China $1.4 bn $549 mn
440 AlloVir Boston Area, US $1.4 bn $0 mn
441 Hybio Pharma Guangdong Province, China $1.4 bn $85 mn
442 URSAPHARM Saarbrucken, Germany $1.4 bn $206 mn
443 Uniao Qufmica Sao Paolo, Brazil $1.4 bn $376 mn
444 HEC Pharma Guangdong Province, China $1.4 bn $741 mn
445 Zhongxin Pharma Tianjin, China $1.3 bn $955 mn
446 MacroGenics Rockville MD, US $1.3 bn $77 mn
447 Kern Pharma Barcelona, Spain $1.3 bn $368 mn
448 Medison Israel $1.3 bn $200 mn
449 Theravance Biopharma Bay Area, US $1.3 bn $76 mn
450 Cosmo Pharma Lugano, Switzerland $1.3 bn $75 mn
451 Nestle Pharma Ops Vevey, Switzerland $1.3 bn $288 mn
452 Cerevel Therapeutics Boston Area, US $1.3 bn NA
453 Atnahs London, United Kingdom $1.3 bn $360 mn
454 Compugen Israel $1.3 bn NA
455 Coherus Bay Area, US $1.3 bn $487 mn
456 Mersana Boston Area, US $1.3 bn $1.6 mn
457 II-Yang Pharm. South Korea $1.3 bn $270 mn
458 Kura Oncology San Diego, US $1.3 bn NA
459 Madrigal Pharma Philadelphia Area, US $1.3 bn NA
460 GNI Group Tokyo, Japan $1.3 bn $77 mn
461 KUP South Korea $1.2 bn $136 mn
462 Weiguang Biological Guangdong Province, China $1.2 bn $122 mn
463 Changshan Bio Hebei Province, China $1.2 bn $308 mn
464 Nordic Pharma Paris, France $1.2 bn $182 mn
465 Ringpu BioTech Hebei Province, China $1.2 bn $245 mn
466 Renata Bangladesh $1.2 bn $310 mn
467 Gloria Pharmaceuticals Heilongjiang Province, China $1.2 bn $527 mn
468 Zealand Pharma Copenhagen, Denmark $1.2 bn $38 mn
469 Medy-Tox South Korea $1.2 bn $151 mn
470 Beam Therapeutics Boston Area, US $1.2 bn NA mn
471 Ligand San Diego, US $1.2 bn $126 mn
472 Leadiant Biosciences Rome, Italy $1.2 bn $180 mn
473 Zhenghai Biotech Shandong Province, China $1.2 bn $39 mn
474 Reliance Life Sciences Mumbai, India $1.2 bn $116 mn
475 Nkarta Bay Area, US $1.2 bn $0 mn
476 GuangYuYuang Shaanxi Province, China $1.2 bn $156 mn
477 Mayinglong Pharma Hubei Province, China $1.2 bn $341 mn
478 Zeria Pharma Tokyo, Japan $1.2 bn $543 mn
479 Laboratoire Aguettant Lyon, France $1.2 bn $177 mn
480 Adaptimmune Oxford, UK $1.2 bn $2.2 mn
481 Duchesnay Quebec, Canada $1.2 bn $175 mn
482 Mezzion South Korea $1.2 bn $17 mn
483 Rocket Pharma New York Area, US $1.2 bn NA
484 Akero Therapeutics Bay Area, US $1.2 bn NA
485 Alvotech Iceland $1.2 bn NA
486 Kanion Pharma Jiangsu Province, China $1.1 bn $545 mn
487 Hansa BioPharma Lund, Sweden $1.1 bn $0.3 mn
488 Synthon Netherlands $1.1 bn $316 mn
489 Innoviva Bay Area, US $1.1 bn $299 mn
490 Heron Therapeutics San Diego, US $1.1 bn $125 mn
491 Athenex New York Area, US $1.1 bn $140 mn
492 SAIDAL Algeria $1.1 bn $313 mn
493 Faes Farma Madrid, Spain $1.1 bn $458 mn
494 VTR Bio-tech Guangdong Province, China $1.1 bn $298 mn
495 Helixsmith South Korea $1.1 bn $4.4 mn
496 Amarin New York Area, US $1.1 bn $545 mn
497 Haw Par Corporation Singapore $1.1 bn $130 mn
498 Sam Chun Dang Pharm South Korea $1.1 bn $152 mn
499 Rhythm Pharma Boston Area, US $1.1 bn NA
500 iTeos Therapeutics Boston Area, US $1.1 bn $0 mn
501 Strides Bangalore, India $1.1 bn $377 mn
502 Kyorin Tokyo, Japan $1.1 bn $1 bn
503 Kaken Pharma Tokyo, Japan $1.1 bn $788 mn
504 Epizyme Boston Area, US $1.1 bn $13 mn
505 Nurix Therapeutics Bay Area, US $1.1 bn $19 mn
506 Camurus Lund, Sweden $1.1 bn $22 mn
507 Arbor Pharma Atlanta, US $1.1 bn $300 mn
508 Stendhal Pharma Mexico $1.1 bn $300 mn
509 Chengdu Baiyu Sichuan Province, China $1.1 bn $300 mn
510 Pulike Biological Henan Province, China $1.1 bn $108 mn
511 Bharat Biotech Hyderabad, India $1.1 bn $106 mn
512 Phibro Animal Health New York Area, US $1.1 bn $800 mn
513 Vianex Greece $1.1 bn $297 mn
514 Mithra Belgium $1.1 bn $108 mn
515 LACER Barcelona, Spain $1.1 bn $162 mn
516 Mayoly Spindler Paris, France $1.1 bn $161 mn
517 Lummy Pharma Sichuan Province, China $1.1 bn $235 mn
518 DONGKOOK Pharma South Korea $1.1 bn $433 mn
519 TECNIMEDE Portugal $1 bn $290 mn
520 Oscotec South Korea $1 bn $15 mn
521 Eczacibasi Mac Sanayi Levent, Turkey $1 bn $157 mn
522 Eurocept Netherlands $1 bn $288 mn
523 IBI Aprilia, Italy $1 bn $288 mn
524 Science Sun Beijing, China $1 bn $161 mn
525 Cristalia Sao Paolo, Brazil $1 bn $287 mn
526 Pharmicell South Korea $1 bn $23 mn
527 Sanjin Guangxi Province, China $1 bn $226 mn
528 Pharmathen Netherlands $1 bn $285 mn
529 Precigen Germantown MD, US $1 bn $95 mn
530 KPC Yunnan Province, China $1 bn $1.1 bn
531 Jiuzhitang Hubei Province, China $1 bn $471 mn
532 C Labs Madrid, Spain $1 bn $283 mn
533 Dr. Kade Berlin, Germany $1 bn $154 mn
534 Generation Bio Boston Area, US $1 bn $0 mn
535 BioXcel Therapeutics New York Area, US $1 bn NA
536 Adimmune Taiwan $1 bn $53 mn
537 Cadila Pharma Ahmedabad, India $1 bn $280 mn
538 Sana Seattle, US $1 bn NA
539 AYUMI Pharmaceutical Tokyo, Japan $1 bn $239 mn
540 Adverum Biotechnologies Bay Area, US $1 bn $0.2 mn
541 Karyopharm Boston Area, US $999 mn $82 mn
542 Haixin Group Shanghai, China $998.3 mn $146 mn
543 Lantheus Boston Area, US $997.3 mn $331 mn
544 Zogenix Bay Area, US $994.7 mn $4.8 mn
545 Tris Pharma Monmouth Junction NJ, US $990 mn $150 mn
546 Zhejiang Int’l Group Zhejiang Province, China $989.3 mn $3.6 bn
547 Annexon Bay Area, US $988.4 mn $0 mn
548 Guanhao Biotech Guangdong Province, China $985.3 mn $61 mn
549 Clovis Oncology Colorado, U.S. $983.4 mn $159 mn
550 Bottu Morocco $981 mn $272 mn
551 NGM Biopharmaceuticals Bay Area, US $979.7 mn $96 mn
552 Normon Madrid, Spain $979.2 mn $272 mn
553 Zentalis Pharma New York Area, US $974 mn $0 mn
554 Pharscin Pharma Sichuan Province, China $971.8 mn $115 mn
555 Oncopeptides Sweden $970.7 mn NA
556 Huaren Pharma Shandong Province, China $968.4 mn $189 mn
557 Fudan Forward Shanghai, China $964.2 mn $139 mn
558 Wockhardt Mumbai, India $964.1 mn $359 mn
559 Yipinhong Pharma Guangdong Province, China $960.8 mn $214 mn
560 TerSera Therapeutics Chicago Area $957 mn $145 mn
561 Eris Lifesciences Limited Ahmedabad, India $956.1 mn $142 mn
562 Dexa Medica Medan City, Indonesia $951 mn NA
563 Avidity Biosciences San Diego, US $949.2 mn $4.9 mn
564 Tonghua Golden-Horse Jilin Province, China $943.7 mn $213 mn
565 Shandong Shanda Shandong Province, China $941.4 mn $257 mn
566 Sosei Tokyo, Japan $940.1 mn $66 mn
567 Beijing Beilu Pharma Beijing, China $937.2 mn $111 mn
568 Amphastar Pharma Los Angeles, US $936.9 mn $334 mn
569 Takata Pharmaceutical Saitama, Japan $936 mn NA
570 Tabuk Pharma Riyadh, Saudi Arabia $936 mn $260 mn
571 Omeros Seattle, US $935 mn $100 mn
572 Healios Tokyo, Japan $932.4 mn $2.3 mn
573 Nippon Kayaku Pharma Tokyo, Japan $928 mn $444mm
574 Kiniksa Pharma Boston Area, US $926.3 mn NA
575 Boston Scientific Pharma Boston Area, US $924 mn $140 mn
576 Renhe Jiangxi Province, China $921.5 mn $577 mn
577 Applied Molecular Transp Bay Area, US $920.5 mn $0 mn
578 Tai’an Tang Pharma Shanghai, China $918.6 mn $547 mn
579 Arcus Biosciences Bay Area, US $914.1 mn $15 mn
580 Arcturus Therapeutics San Diego, US $910.4 mn $11 mn
581 Vetoquinol Paris, France $906.1 mn $444 mn
582 JW Holdings South Korea $905.5 mn $618 mn
583 Esperion Ann Arbor, MI, US $904.9 mn $216 mn
584 Apsen Sao Paolo, Brazil $900 mn $250 mn
585 Dexcel Pharma Israel $900 mn $250 mn
586 Agenus Boston Area, US $897.9 mn $96 mn
587 J. B. Chemicals Mumbai, India $897.5 mn $245 mn
588 Jingxin Pharm Zhejiang Province, China $895.1 mn $485 mn
589 Intellia Therapeutics Boston Area, US $894.5 mn $50 mn
590 Mochida Tokyo, Japan $892.1 mn $952 mn
591 Osiris Columbia MD, US $888.3 mn $134 mn
592 SKK Tokyo, Japan $887.3 mn $424 mn
593 Stoke Therapeutics, Inc. Boston Area, US $887 mn NA
594 Ampharco U.S.A. Nhon Trach, Vietnam $885.5 mn $245 mn
595 Oxford BioMedica Oxford, UK $885.1 mn $81 mn
596 Shanghai Furen Shanghai, China $884.9 mn $529 mn
597 Binex South Korea $884.1 mn $107 mn
598 Daewoong South Korea $884 mn $890 mn
599 Zhendong Pharma Shanxi Province, China $881.9 mn $622 mn
600 Sangamo Therapeutics Bay Area, US $881.8 mn $111 mn
601 TaiMed Biologics Taiwan $878.8 mn $28 mn
602 PharmaEssentia Taiwan $877.2 mn $11 mn
603 Jiangzhong Pharma Jiangxi Province, China $870.6 mn $349 mn
604 Pharm-Sintez Moscow, Russia $865.8 mn $240 mn
605 Dong-A Socio South Korea $860 mn $659 mn
606 Jingfeng Pharma Shanghai China $858 mn $172 mn
607 Jiudian Pharma Changsha, China $846.8 mn $126 mn
608 Incepta Pharma Bangladesh $843.7 mn $234 mn
609 Black Diamond Tx Boston Area, US $842.4 mn NA
610 Immunocore Oxford, UK $839.4 mn NA
611 Bosnalijek Bosnia-Herzegovina $837.7 mn $232 mn
612 Bilim Pharmaceuticals Turkey $836.2 mn $232 mn
613 Qianhong Biopharma Jiangsu Province, China $835.6 mn $210 mn
614 Akorn Chicago Area $833 mn $682 mn
615 Supernus Rockville MD, US $832.6 mn $424 mn
616 Jinhe Biotech Liaoning Province, China $830.8 mn $254 mn
617 Repare Therapeutics Toronto, Canada $830.4 mn $0 mn
618 REGENXBIO Rockville MD, US $828.4 mn $60 mn
619 Poseida Therapeutics San Diego, US $828.2 mn $0 mn
620 Atara Biotherapeutics Bay Area, US $827.8 mn NA
621 Beijing Tong Ren Tang Hebei Province, China $825.3 mn $600 mn
622 Tong Ren Tang Tech Beijing, China $825.3 mn $600 mn
623 Lingrui Pharma Henan Province, China $824.3 mn $306 mn
624 Xinhua Pharm Shandong Province, China $823.7 mn $816 mn
625 Cstone Pharma Jiangsu Province, China $822.9 mn $3.2 mn
626 Chong Kun Dang Pharm South Korea $821.1 mn $662 mn
627 Yoshindo Toyama, Japan $817 mn $391 mn
628 Atea Pharma Boston Area, US $817 mn NA
629 SanBio Tokyo, Japan $814 mn $0.1 mn
630 Nihon Chouzai Generics Tokyo, Japan $808.8 mn $2.5 bn
631 Laboratoires Brothier Fontevraud-l’Abbaye, France $805.8 mn $223 mn
632 Bioiberica Barcelona, Spain $803.7 mn $223 mn
633 Arvinas New York Area, US $802 mn $46 mn
634 Jolly Pharmaceutical Zhejiang Province, China $801.4 mn $134 mn
635 Pharmaceutical Associates Washington DC Area $800 mn $100 mn
636 Collegium Pharmaceutical Boston Area, US $797.7 mn $301 mn
637 Komipharm International South Korea $797.6 mn $31 mn
638 Guidotti Pisa, Italy $797.1 mn $221 mn
639 AOP Orphan Austria $794.3 mn $120 mn
640 Zdrowie Poland $793 mn $220 mn
641 Farmigea Pisa, Italy $790.2 mn $119 mn
642 Vectura London, United Kingdom $784.2 mn $218 mn
643 Keros Therapeutics Boston Area, US $782.5 mn $5 mn
644 The GPO Thailand $779.7 mn $216 mn
645 Tolmar / Tecnofarma Colombia $778.8 mn $118 mn
646 Eusa Pharma London, United Kingdom $778.8 mn $87 mn
647 Ji Yao Holding Jilin Province, China $774 mn $9.5 bn
648 Laboratoire Renaudin Itxassou, France $772 mn $214 mn
649 Lannett Philadelphia Area, US $771.9 mn $545 mn
650 Yibai Pharmaceutical Guizhou, China $770 mn $456 mn
651 BioArctic Norway $768.9 mn $9.8 mn
652 Wohua Pharma Shandong Province, China $765.8 mn $131 mn
653 Vericel Boston Area, US $765.7 mn $116 mn
654 Havea Group Bouffere, France $764.6 mn $212 mn
655 Prati, Donaduzzi & Cia. Toledo, Brazil $763.2 mn $212 mn
656 Lionco Pharma Zhejiang Province, China $762.4 mn $180 mn
657 Innovis Pharma Greece $760.3 mn $211 mn
658 RAPT Therapeutics Bay Area, US $756.9 mn $2.2 mn
659 Farmak Kiev, Ukraine $756 mn $236 mn
660 Medis o.o.o. Llubjana, Slovenia $755.4 mn $114 mn
661 Retrophin San Diego, US $754.5 mn $187 mn
662 Kocak Farma Istanbul, Turkey $752.4 mn $209 mn
663 Clinuvel Pharma Zurich, Switzerland $751.1 mn $22 mn
664 VBI Vaccines Boston Area, US $749.5 mn $1.8 mn
665 Replimune Boston Area, US $745 mn NA
666 Pharming Netherlands $743.8 mn $202 mn
667 Valenta Pharma Moscow, Russia $743.4 mn $206 mn
668 Inhibrx San Diego, US $743.1 mn NA
669 Desitin Hamburg, Germany $742.5 mn $112 mn
670 CrystalGenomics South Korea $740.2 mn $77 mn
671 FDC Mumbai, India $739.3 mn $173 mn
672 Kai Bao Pharma Shanghai, China $739.1 mn $156 mn
673 Blau Farmaceutica Cotia, Brazil $738.7 mn $205 mn
674 Fatro Milan, Italy $735.9 mn $111 mn
675 Arcutis Biotherapeutics Los Angeles, US $735.7 mn NA
676 NantKwest Los Angeles, US $735.4 mn NA
677 Translate Bio Lexington, MA $734.3 mn $26 mn
678 SIFI Sicily, Italy $731.1 mn $203 mn
679 Liminal BioSciences Quebec, Canada $729.1 mn NA
680 Jiangsu Sihuan Bio Jiangsu Province, China $729 mn $68 mn
681 Geropharm Russia $727.2 mn $72 mn
682 Maruishi Pharma Osaka, Japan $726.3 mn $347 mn
683 Currax Pharma New York Area, US $726 mn $110 mn
684 Yabao Pharmaceutical Shanxi Province, China $722 mn $370 mn
685 Exela Pharma Lenoir, NC $720 mn $200 mn
686 Nippon Zoki Osaka, Japan $718.9 mn $199 mn
687 Hengkang Medical Sichuan Province, China $716.6 mn $437 mn
688 Senju Pharma Osaka, Japan $710.6 mn $401 mn
689 Phathom Pharma New York Area, US $710.4 mn NA
690 Cosunter Fujian Province, China $709.8 mn $52 mn
691 Farabi Pharma Iran $709.2 mn $197 mn
692 Teuto Goias, Brazil $705.6 mn $196 mn
693 Acme Pharmaceuticals Bangladesh $704.5 mn $195 mn
694 Julphar United Arab Emirates $703.8 mn $102 mn
695 AB Science Paris, France $703.1 mn $1.7 mn
696 Jinghua Pharma Jiangsu Province, China $698.9 mn $159 mn
697 Dicerna Pharma Boston Area, US $692.1 mn $89 mn
698 Boryung Pharma South Korea $689.9 mn $456 mn
699 Beximco Pharma Bangladesh $689.9 mn $295 mn
700 MiMedx Atlanta, US $687.8 mn $280 mn
701 Staidson Beijing, China $686.8 mn $68 mn
702 Emisphere Technologies New York Area, US $675.7 mn $1 mn
703 Konruns Pharma Beijing, China $673.8 mn $123 mn
704 Exir Pharmaceutical Iran $671 mn $186 mn
705 DOC Generici Milan, Italy $669.6 mn $186 mn
706 Radius Boston Area, US $669 mn $200 mn
707 SillaJen South Korea $667.8 mn $1.9 mn
708 Basilea Basel, Switzerland $667.6 mn $148 mn
709 Vaxart Bay Area, US $667.3 mn $7.7 mn
710 Pharmasyntez Irkutsk, Russia $666 mn $185 mn
711 Cisen Pharmaceutical Shandong Province, China $663 mn $539 mn
712 Tchaikapharma Bulgaria $662.3 mn NA
713 MedDay Pharma Paris, France $660 mn NA
714 Pharmacosmos Copenhagen, Denmark $660 mn $100 mn
715 Eumedica Belgium $660 mn $100 mn
716 Shilpa Bangalore, India $658.2 mn $128 mn
717 Alector Bay Area, US $655.1 mn $19 mn
718 Senhwa Taiwan $653.1 mn NA
719 Dr. August Wolff Bielefield, Germany $649.5 mn $98 mn
720 Cellectis Paris, France $648.2 mn $73 mn
721 Kissei Matsumoto, Japan $647.1 mn $586 mn
722 SPARC Mumbai, India $644.4 mn $32 mn
723 Nobel Turkey $644.4 mn $179 mn
724 Indofarma Indonesia $642.9 mn $99 mn
725 Medigen Vaccine Taiwan $639.9 mn NA
726 Flexion Therapeutics Boston Area, US $639.8 mn $81 mn
727 Laboratoires Genevrier Lyon, France $639.4 mn $96 mn
728 Kadmon New York Area, US $632.1 mn $11 mn
729 Mayne Pharma Melbourne, Australia $624.6 mn $315 mn
730 Morphic Therapeutics Boston Area, US $622.4 mn $18 mn
731 Ozon Pharmaceuticals Russia $622 mn $172 mn
732 OBI Pharma Taiwan $617.4 mn $2 mn
733 Albireo Pharma Boston Area, US $616.9 mn $11 mn
734 Sinovac Beijing, China $615 mn $213 mn
735 Krystal Biotech Pittsburgh Area, US $614.6 mn NA
736 Provention Bio, Inc. New York Area, US $614 mn NA
737 ZENOAQ Tokyo, Japan $612.3 mn $293 mn
738 Alora Pharma Atlanta, US $612 mn $170 mn
739 Pliant Therapeutics Bay Area, US $608.7 mn $89 mn
740 Sciclone Shanghai, China $605 mn NA
741 Dynavax Bay Area, US $604.1 mn $34 mn
742 Handok South Korea $602.5 mn $405 mn
743 BioCryst North Carolina, US $602.3 mn $49 mn
744 Weixinkang Medicine Lhasa, Tibet, China $601.2 mn $95 mn
745 PKU HealthCare Corp. Sichuan Province, China $600.2 mn $311 mn
746 Inozyme Pharma Boston Area, US $597.4 mn $0 mn
747 Protagonist Therapeutics Bay Area, US $594.4 mn $16 mn
748 HRA Pharma New York Area, US $594 mn $90 mn
749 Molecular Templates Austin, Texas $592.7 mn $20 mn
750 Boiron Lyon, France $590.4 mn $623 mn
751 Nephron Pharma West Columbia, SC $589.3 mn $163 mn
752 CCM Duopharma Biotech Malaysia $586.4 mn $135 mn
753 Hiteck Biological Pharma Wuhan, China $585.7 mn $69 mn
754 Deva Holding Turkey $585.4 mn $230 mn
755 Laboraoires Majorelle Paris, France $583.2 mn $30 mn
756 SOHO Global Healthcare Indonesia $578.8 mn
757 Teikoku Senyaku Higashikagawa, Japan $576.8 mn $276 mn
758 Alliance Pharma London, United Kingdom $571.8 mn $162 mn
759 Caplin Point Laboratories Chennai, India $568.7 mn $120 mn
760 Nativa Russia $567.3 mn $157 mn
761 Cara Therapeutics New York Area, US $565.9 mn $24 mn
762 Grupo Medinfar Portugal $565.4 mn $157 mn
763 Gongwin Biopharm Taiwan $564.9 mn NA
764 Cassiopea S.p.A. Milan, Italy $564.7 mn $0.7 mn
765 Bath ASU London, United Kingdom $564.5 mn $156 mn
766 Frequency Therapeutics Boston Area, US $563.9 mn $44 mn
767 Foci Pharmaceutical Gansu Province, China $562.6 mn $91 mn
768 DEMO Greece $561.5 mn $155 mn
769 Newbridge Pharma United Arab Emirates $561 mn $85 mn
770 Inibsa Barcelona, Spain $560.6 mn $155 mn
771 Taloph Henan Province, China $559 mn $193 mn
772 Famar Greece $557.3 mn $154 mn
773 Akouos Therapeutics Boston Area, US $557.1 mn $0 mn
774 TTY Biopharm Taiwan $555.9 mn $144 mn
775 Amryt Pharma Ireland $554.4 mn NA
776 Intersect ENT Bay Area, US $552.9 mn $85 mn
777 HAL Allergy Netherlands $552.4 mn $83 mn
778 Hansen Pharm Hubei Province, China $551.2 mn $110 mn
779 Biosidus Argentina $551 mn $54 mn
780 Northwest Bio Bethesda MD, US $548 mn $2 mn
781 Farmfirma Soteks Russia $544.6 mn $151 mn
782 Jianmin Group Hubei Province, China $542.5 mn $304 mn
783 Cau Technology Guangdong Province, China $541.9 mn $7.6 mn
784 WAVE Life Sciences Boston Area, US $541.1 mn $12 mn
785 Elpen Pharma Greece $540 mn $150 mn
786 Petrovax Russia $538.5 mn $149 mn
787 Autolus Therapeutics London, United Kingdom $537.7 mn $1.2 mn
788 Berlin Pharma Thailand $536.4 mn $149 mn
789 Recursion Pharma Salt City, Utah $529 mn NA
790 Saol Therapeutics Atlanta, US $528 mn $80 mn
791 Sito Bio Shandong Province, China $527.8 mn $124 mn
792 TaiGen Taiwan $526.2 mn $0.7 mn
793 Taiwan Biotech Taiwan $525.4 mn $145 mn
794 ImmunoGen Boston Area, US $525 mn $86 mn
795 Kyowa Pharmaceutical Osaka, Japan $525 million $230 mm
796 JGL Croatia $523.5 mn $145 mn
797 Lepu Bio Shanghai, China $523 mn NA
798 Honz Pharma Guangdong Province, China $521.8 mn $127 mn
799 Getz Pharma Pakistan $520.2 mn $144 mn
800 ANI Pharmaceuticals Minnesota, US $519.6 mn $197 mn
801 PharmaResearch Prod. South Korea $519.4 mn $76 mn
802 Yakult Pharma Segment Tokyo, Japan $519 mn NA
803 Freeline Therapeutics Stevenage, UK $518.3 mn $0 mn
804 Gossamer Bio San Diego, US $516.6 mn NA
805 Shenqi Pharmaceutical Guizhou, China $516.2 mn $262 mn
806 DHG Pharma Can Tho, Vietnam $516 mn $164 mn
807 Valneva Lyon, France $515.7 mn $134 mn
808 Ocular Therapeutix Boston Area, US $515.5 mn $7.2 mn
809 Hua Medicine Hong Kong $513 mn $3.1 mn
810 Enanta Boston Area, US $512.2 mn $150 mn
811 Rana Pharm South Korea $511.2 mn $142 mn
812 Cosar Pharmaceutical Iran $511.2 mn $142 mn
813 Aerie Pharmaceuticals North Carolina, US $510.2 mn $81 mn
814 Organogenesis Boston Area, US $508.1 mn $269 mn
815 TherapeuticsMD Boca Raton, FL $506.2 mn $62 mn
816 Consilient Health Ireland $506.2 mn $76 mn
817 Huons South Korea $505.1 mn $402 mn
818 SIGA Technologies New York Area, US $504.9 mn $55 mn
819 Syndax Pharmaceuticals Boston Area, US $504.6 mn $1.5 mn
820 Corium Bay Area, US $504 mn NA
821 Genor Biopharma Shanghai, China $503 million NA
822 IE Ulagay Turkey $501.4 mn $139 mn
823 Ambiopharm North August, SC, US $500 mn NA
824 Odin Pharmaceuticals Somerset NJ $500 mn $80 mn
825 NKMax Los Angeles, US $496.5 mn $7.6 mn
826 Teyi Pharmaceutical Group Guangdong Province, China $496 mn $105 mn
827 Jeil South Korea $495.1 mn $624 mn
828 TCR2 Therapeutics Boston Area, US $494.3 mn NA
829 Celon Pharma Poland $494.2 mn $25 mn
830 Hicin Jiangsu Province, China $493.8 mn $119 mn
831 Fengyuan Pharmaceutical Anhui Province, China $493.3 mn $459 mn
832 kaleo Richmond, Virginia $492.2 mn $125 mn
833 Aprea Therapeutics, Inc. Boston Area, US $491.8 mn NA
834 AMAG Pharma Boston Area, US $489.7 mn $297 mn
835 Aprogen Pharmaceuticals South Korea $486.4 mn $45 mn
836 Pandion Therapeutics Boston Area, US $484.9 mn $4.9 mn
837 Green Cross Cell South Korea $483 mn $31 mn
838 Arterium Kiev, Ukraine $482.7 mn $134 mn
839 Sopharma Bulgaria $480.7 mn $775 mn
840 OM Pharm Zurich, Switzerland $478 mn $101 mn
841 ZIOPHARM Oncology Boston Area, US $476.2 mn NA
842 ASKA Pharmaceutical Tokyo, Japan $474.7 mn $484 mn
843 Dongwha Pharm South Korea $473.6 mn $245 mn
844 Relmada Therapeutics New York, NY $471.4 mn NA
845 YungShin Global Taiwan $470.4 mn $280 mn
846 Vertice Pharma New York Area, US $468 mn $130 mn
847 Farmac-Zabban Bologna, Italy $467.8 mn $129 mn
848 MannKind Los Angeles, US $466 mn $61 mn
849 Ansun Biopharma San Diego, US $466 million NA
850 BiondVax Pharmaceuticals Israel $464.8 mn NA
851 Amlyx Boston Area, US $464 million NA
852 XOMA Bay Area, US $463.8 mn $10 mn
853 Codupha Ho Chi Minh, Vietnam $463.6 mn $128 mn
854 Yatai Pharma Zhejiang Province, China $463.4 mn $55 mn
855 SERB Belgium $463.3 mn $70 mn
856 FangSheng Pharma Hubei Province, China $462.8 mn $160 mn
857 CMG Pharma South Korea $462.5 mn $49 mn
858 Romark Tampa, FL $462 mn $70 mn
859 Reig Jofre Barcelona, Spain $461.8 mn $257 mn
860 Poly Pharmaceuticals Huntsville, AL $460.8 mn $128 mn
861 Lianhuan Pharma Jiangsu Province, China $459.7 mn $191 mn
862 Eagle Pharma New York Area, US $458.4 mn $177 mn
863 Odonate Therapeutics San Diego, US $456.5 mn NA
864 Qianjin Pharmaceutical Hubei Province, China $455.6 mn $497 mn
865 Cue Biopharma Boston Area, US $454.7 mn $4 mn
866 Longjin Pharmaceutical Yunnan Province, China $452.3 mn $34 mn
867 ORIC Pharma Bay Area, US $451.9 mn NA
868 Jiaying Pharmaceutical Guangdong Province, China $451.6 mn $69 mn
869 Hanlim South Korea $448.5 mn $124 mn
870 Daito Pharmaceutical Toyama, Japan $448.3 mn $417 mn
871 Guangji Pharmaceutical Hubei Province, China $448.2 mn $100 mn
872 Silence Therapeutics London, United Kingdom $447.1 mn $1.7 mn
873 Bristol Laboratories London, United Kingdom $445.2 mn $123 mn
874 Pengqi Technology Devp Shanghai China $443.1 mn $121 mn
875 Soria Natural Garray, Spain $442.7 mn $122 mn
876 MIP Group Blieskastel, Germany $442.4 mn $122 mn
877 Osmotica New York Area, US $440.1 mn $211 mn
878 SALVAT Barcelona, Spain $440 mn $66 mn
879 Jacobson Pharma Hong Kong $439.4 mn $202 mn
880 Indivior Richmond, Virginia $439.4 mn $634 mn
881 Eutilex South Korea $439.1 mn $0.8 mn
882 89bio Bay Area, US $439.1 mn NA
883 Aptose Biosciences Toronto Area, Canada $438.8 mn NA
884 Pharma Foods International Kyoto, Japan $437.7 mn $145 mn
885 Anika Therapeutics Boston Area, US $437 mn $125 mn
886 Starpharma Melbourne, Australia $435.8 mn $4.5 mn
887 Lisheng Pharma Hebei Province, China $435.1 mn $194 mn
888 Taihe Health Technology Sichuan Province, China $433.3 mn $101 mn
889 Farma de Colombia SAS Colombia $432 mn $120 mn
890 Brainstorm Cell Tx New York Area, US $431.7 mn NA
891 RedHill Biopharma Tel-Aviv, Israel $431.1 mn $24 mn
892 Spectrum Las Vegas, NV $430.1 mn NA
893 Anterogen South Korea $428.6 mn $3.4 mn
894 Tricida Bay Area, US $428 mn NA
895 Panlong Pharmaceutical Shangluo, China $426 mn $64 mn
896 Alter Pharma Belgium $424.8 mn $118 mn
897 Passage Bio, Inc. Philadelphia Area, US $423.4 mn NA
898 Molecular Partners Zurich, Switzerland $422.3 mn $15 mn
899 Caregen South Korea $422.2 mn $53 mn
900 Ferndale Pharma Group Michigan, US $421.7 mn $63 mn
901 Franco-Indian (FIPPL) Mumbai, India $420.7 mn $116 mn
902 La borate Pharmaceuticals Haryana, India $420.1 mn $116 mn
903 Qianjiang Pharmaceutical Hubei Province, China $418.5 mn $111 mn
904 Highland Therapeutics Toronto Area, Canada $418 mn NA
905 Molteni Florence, Italy $417.7 mn $63 mn
906 TOA EIYO Tokyo, Japan $416 mn $131 mn
907 Syros Pharma Boston Area, US $414.3 mn $6.6 mn
908 Medigen Taiwan $413.1 mn $18 mn
909 Beyond Spring Pharma New York Area, US $412.5 mn NA
910 Theragen Etex South Korea $412.4 mn $114 mn
911 Calliditas Therapeutics Sweden $412.2 mn $5 mn
912 Vyera Therapeutics New York Area, US $411.8 mn $62 mn
913 Neoleukin Therapeutics Seattle, US $411.6 mn NA
914 Daewon Pharm South Korea $410.9 mn $265 mn
915 HLS Therapeutics Toronto Area, Canada $409.8 mn $53 mn
916 Puma Biotechnology Los Angeles, US $409.2 mn $241 mn
917 Kymab Cambridge, UK $408.5 mn NA
918 Seikagaku Tokyo, Japan $408.2 mn $259 mn
919 Diachem Bergamo, Italy $408.2 mn $113 mn
920 Adcock Ingram South Africa $407.5 mn $423 mn
921 Applied Therapeutics, Inc. New York Area, US $404.7 mn NA
922 Instituto Vital Brazil Rio de Janeiro, Brazil $403.3 mn $112 mn
923 iNtRON Biotechnology South Korea $403.2 mn $25 mn
924 Moehs Barcelona, Spain $401.8 mn $111 mn
925 US WorldMeds Louisville, KY, US $400 mn NA
926 Yisheng Pharma Jilin Province, China $398.9 mn $128 mn
927 BioDelivery Sciences North Carolina, US $397.8 mn $136 mn
928 Cosette Pharma New York Area, US $396 mn $110 mn
929 Aft Pharm New Zealand $395.4 mn $62 mn
930 Synmosa Biopharma Taiwan $393.9 mn $97 mn
931 Ardelyx Bay Area, US $391.9 mn $8.3 mn
932 Bluefish Pharmaceuticals Stockholm, Sweden $391.7 mn $108 mn
933 Furui Beijing, China $390.6 mn $114 mn
934 G1 Therapeutics North Carolina, US $390.4 mn $2.1 mn
935 Blue Pharma-Industria Portugal $389.2 mn $108 mn
936 Belupo Croatia $385.2 mn $107 mn
937 Ohara Pharma Tokyo, Japan $384.3 mn $183 mn
938 Mirum Pharmaceuticals Bay Area, US $384.2 mn NA
939 Cellular Biomedicine Bay Area, US $382.3 mn $0.2 mn
940 Sihuan Pharma Beijing, China $382.2 mn $323 mn
941 Neutec Ilac Turkey $378.3 mn $105 mn
942 Ildong Pharmaceutical South Korea $378 mn $467 mn
943 AC Immune Lausanne, Switzerland $376.4 mn $50 mn
944 Lee’s Pharmaceutical Hong Kong $376 mn $150 mn
945 VIVUS Bay Area, US $375.5 mn $56 mn
946 Scholar Rock Holding Boston Area, US $371.4 mn $21 mn
947 Therabel Pharma Netherlands $370 mn NA
948 Humanigen Bay Area, US $369.6 mn NA
949 Fortress Biotech New York Area, US $369.5 mn $43 mn
950 Savior Lifetec Taiwan $368.7 mn $52 mn
951 Assembly Biosciences Bay Area, US $368.2 mn $52 mn
952 Rigel Pharmaceuticals Bay Area, US $367.8 mn $108 mn
953 Kala Pharmaceuticals Boston Area, US $367.7 mn $4.5 mn
954 Materia Medica Moscow, Russia $367.2 mn $102 mn
955 Fuji Pharma Tokyo, Japan $365.8 mn $314 mn
956 Ovid Therapeutics New York Area, US $364.7 mn NA
957 TransMedics Group Andover, MA $363.1 mn $24 mn
958 Kintor Pharma Jiangsu Province, China $362.5 mn $0 mn
959 Urovant Sciences Irvine, CA $362.3 mn $0 mn
960 Darnitsa Ukraine $360 mn $100 mn
961 MS Pharma – El Kendi Algeria $360 mn $100 mn
962 Ascendis Health South Africa $359.3 mn $427 mn
963 Kolon Life Sciences South Korea $358.9 mn $128 mn
964 Nissin Tendo, Japan $358.1 mn $171 mn
965 Indoco Mumbai, India $357.3 mn $149 mn
966 Atreca Bay Area, US $357 mn NA
967 Alium Group Russia $355.6 mn $98 mn
968 The Searle Company Pakistan $355.3 mn $98 mn
969 Kwang Dong Pharma South Korea $353.9 mn $1 bn
970 Jinling Pharma Jiangsu Province, China $353.7 mn $338 mn
971 Verona Pharma London, United Kingdom $351.5 mn NA
972 EIPICO Egypt $351.5 mn $192 mn
973 HNSP Hainan Province, China $350.6 mn $40 mn
974 AVROBIO Boston Area, US $350.5 mn NA
975 Checkmate Pharma Boston Area, US $350.4 mn NA
976 Xinguan Pharmaceutical Zhejiang Province, China $350.2 mn $39 mn
977 Flynn Pharma London, United Kingdom $349.9 mn $59 mn
978 Tanvex Taiwan $349.2 mn NA
979 C&Y Group Shanxi Province, China $347.7 mn $137 mn
980 ACME Laboratories Bangladesh $347.5 mn $213 mn
981 TAEJOON PHARM South Korea $347 mn $96 mn
982 Farmabase Jaguariuna, Brazil $346.5 mn $52 mn
983 Xbiotech Austin, TX, US $345.1 mn $28 mn
984 Apex Healthcare Malaysia $343.6 mn $167 mn
985 Oyster Point Pharma Princeton, NJ, US $342.2 mn NA
986 Athersys, Inc. Cleveland, Ohio $341.7 mn $0 mn
987 Paratek Boston Area, US $341.7 mn $30 mn
988 PBF Taiwan $340.3 mn $50 mn
989 Grupo Azevedos Portugal $339.8 mn $94 mn
990 Centaur Pharma Mumbai, India $338.8 mn $94 mn
991 SOTH EMA Morocco $338.4 mn $178 mn
992 Orchard Therapeutics London, United Kingdom $338.4 mn $3.1 mn
993 Cantargia Lund, Sweden $338.4 mn NA
994 Tiansheng Pharma Jiangsu Province, China $337.8 mn $199 mn
995 Tiziana Life Sciences London, United Kingdom $337.3 mn NA
996 Aestura South Korea $336.9 mn $93 mn
997 UroGen Pharma New York Area, US $336.5 mn $0.3 mn
998 Telix Melbourne, Australia $336.4 mn NA
999 China Chemical & Pharma Taiwan $336 mn $272 mn
1000 Shapuaisi Pharma Zhejiang Province, China $335.5 mn $55 mn

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