As of September 2020, there are approximately 1800 pharma companies. The total value of global pharma sector has tripled in the last 17 years from $1.99 in 2003 to $6.65 trillion in 2020. The industry value CAGR since 2003 has been 7.4%.
Evolution of the pharma sector suggests Big Pharma sector grew slowly between 2015 to 2020, losing 5% in value share. In contrast, animal health and biotech sectors grew substantially in the same period.
In terms of specific drug modality, Biologics companies grew as a group by $1.1 trillion in just 5 years. Other big growth areas were vaccines, nucleic acids, peptides, cell therapy and gene therapy.
Considering country level evolution of Pharma industry, most countries have seen a rise, but none has seen an increase more than China which added over $500 billion in value over the last five years. In U.S. there has been an increase if 22% in the last five years.
The bar to be in the Pharma 1000 list has moved up gradually over time though. A company would need to have had a valuation of at least $336 million to be in the top 1000.
See the full list of Top 1000 Pharmaceutical Companies below.
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- The Global Pharmaceutical Industry
- Rapid Growth of Biotech Sector
- The Evolving Branded Pharma Sector
- The Generic Pharma Sector
- Top 1000 Companies by Value
- Profiles of the Top 500 Companies
.
List of Top 1000 Pharmaceutical Companies by Value
.
Value | Name | Headquarters | Value Estimate | Revenue |
| Rank | Location | (Sep 2020) | (Trailing) | |
| 2020 | ||||
| 1 | Roche | Basel, Switzerland | $328 bn | $49 bn |
| 2 | Janssen (J&J) | Raritan, NJ, US | $279 bn | $42 bn |
| 3 | Pfizer | New York Area, US | $257 bn | $49 bn |
| 4 | AbbVie | Chicago Area | $242 bn | $36 bn |
| 5 | Merck | New York Area, US | $233 bn | $47 bn |
| 6 | Novartis | Basel, Switzerland | $210 bn | $49 bn |
| 7 | Amgen | Thousand Oaks, CA, US | $164 bn | $24 bn |
| 8 | AstraZeneca | Boston Area, US | $162 bn | $25 bn |
| 9 | Bristol-Myers Squibb | New York Area, US | $158 bn | $34 bn |
| 10 | Novo Nordisk | Copenhagen, Denmark | $155 bn | $19 bn |
| 11 | Eli Lilly | Indiana, US | $151 bn | $22 bn |
| 12 | Boehringer Ingelheim | Ingelheim, Germany | $148 bn | $22 bn |
| 13 | GlaxoSmithKline | London, United Kingdom | $136 bn | $43 bn |
| 14 | Bayer | Leverkusen, Germany | $133 bn | $20 bn |
| 15 | Sanofi | Paris, France | $120 bn | $42 bn |
| 16 | Takeda | Tokyo Japan | $104 bn | $30 bn |
| 17 | CSL | Parkville, Australia | $100 bn | $9 bn |
| 18 | Gilead | Bay Area, US | $87 bn | $22 bn |
| 19 | Zoetis | New York Area, US | $82 bn | $6.3 bn |
| 20 | Chugai | Tokyo, Japan | $72 bn | $6.8 bn |
| 21 | Hengrui Medicine | Jiangsu Province, China | $69 bn | $3.4 bn |
| 22 | Vertex Pharma | Boston Area, US | $65 bn | $5.4 bn |
| 23 | Regeneron | New York Area, US | $58 bn | $8.6 bn |
| 24 | Daiichi Sankyo | Tokyo, Japan | $54 bn | $8.9 bn |
| 25 | Merck KGaA Pharma | Berlin, Germany | $50 bn | $7.5 bn |
| 26 | Biogen | Boston Area, US | $48 bn | $14 bn |
| 27 | Yangtze River Pharma | Jiangsu Province, China | $44 bn | $12 bn |
| 28 | Servier | Paris, France | $36 bn | $5.4 bn |
| 29 | Teva | Israel | $35 bn | $16 bn |
| 30 | Celltrion | South Korea | $33 bn | $1.2 bn |
| 31 | CSPC Pharma | Hebei Province, China | $33 bn | $5 bn |
| 32 | Zhifei Bio | Sichuan Province, China | $31 bn | $1.7 bn |
| 33 | Seattle Genetics | Seattle, US | $30 bn | $1 bn |
| 34 | Menarini | Florence, Italy | $30 bn | $4.4 bn |
| 35 | Bausch Health | New York Area, US | $29 bn | $8.1 bn |
| 36 | Royalty Pharma | New York Area, US | $29 bn | $1.9 bn |
| 37 | Hansoh Pharma | Lianyungang, China | $26 bn | $1.1 bn |
| 38 | Astellas | Tokyo, Japan | $26 bn | $11 bn |
| 39 | Grifols | Barcelona, Spain | $26 bn | $6 bn |
| 40 | Alexion | New York Area, US | $25 bn | $5.5 bn |
| 41 | Eisai | Tokyo, Japan | $24 bn | $6.5 bn |
| 42 | Moderna | Boston Area, US | $24 bn | $105 mn |
| 43 | Qilu Pharma | Shandong Province, China | $24 bn | $3.6 bn |
| 44 | UCB | Brussels, Belgium | $24 bn | $5.8 bn |
| 45 | Sino Biopharma | Hong Kong | $23 bn | $3.4 bn |
| 46 | Changchun Tech | Jilin Province, China | $23 bn | $1.1 bn |
| 47 | Genmab | Copenhagen, Denmark | $22 bn | $1.5 bn |
| 48 | Otsuka | Tokyo, Japan | $22 bn | $13 bn |
| 49 | Pientzehuang Pharma | Fujian Province, China | $22 bn | $859 mn |
| 50 | Kelun Group | Sichuan Province, China | $22 bn | $6 bn |
| 51 | Galderma | La Tour-de-Peilz, Switzerland | $20 bn | $3 bn |
| 52 | BeiGene | Beijing, China | $20 bn | $224 mn |
| 53 | Mylan | Pittsburgh Area, US | $20 bn | $11 bn |
| 54 | Jemincare | Jianxi Province, China | $19.3 bn | $5.3 bn |
| 55 | Pierre Fabre | Paris, France | $18.7 bn | $2.8 bn |
| 56 | Immunomedics | New York Area, US | $18.6 bn | $20 mn |
| 57 | Incyte | Philadelphia Area, US | $18.5 bn | $2.3 bn |
| 58 | Horizon Therapeutics | Chicago Area | $17.9 bn | $1.5 bn |
| 59 | Yunnan Baiyao | Yunnan Province, China | $17.6 bn | $4.4 bn |
| 60 | Kangtai Bio | Guangdong Province, China | $17.3 bn | $283 mn |
| 61 | Octapharma | Lachen, Switzerland | $17.1 bn | $2.5 bn |
| 62 | Fosun Pharma | Shanghai, China | $16.7 bn | $4 bn |
| 63 | Ferring | Geneva, Switzerland | $16.7 bn | $2.5 bn |
| 64 | Sun Pharma | Mumbai, India | $16.4 bn | $4.2 bn |
| 65 | Abbott EPD | Chicago Area | $16.1 bn | $4.4 bn |
| 66 | Chiesi | Parma, Italy | $15.5 bn | $2.3 bn |
| 67 | BioNTech | Mainz, Germany | $15.4 bn | $141 mn |
| 68 | Ono | Osaka, Japan | $14.7 bn | $2.7 bn |
| 69 | BioMarin | Bay Area, US | $13.8 bn | $1.8 bn |
| 70 | Alnylam | Boston Area, US | $13.5 bn | $345 mn |
| 71 | Elanco | Indiana, US | $13.4 bn | $2.8 bn |
| 72 | Shionogi | Osaka, Japan | $13.3 bn | $3 bn |
| 73 | Mundipharma | New York Area, US | $13.2 bn | $2 bn |
| 74 | Hualan Bio | Henan Province, China | $13.1 bn | $521 mn |
| 75 | NC Pharma / EMS | Hortolandia, Brazil | $12.8 bn | $1.9 bn |
| 76 | Fresenius Kabi Segment | Hessen, Germany | $12.5 bn | $3.4 bn |
| 77 | Walvax | Yunnan Province, China | $12.5 bn | $169 mn |
| 78 | Samumed | San Diego, CA | $12.4 bn | NA |
| 79 | Kyowa Kirin | Tokyo, Japan | $12.2 bn | $2.8 bn |
| 80 | Recordati | Milan, Italy | $12.2 bn | $1.6 bn |
| 81 | Shanghai Pharma – Mfg | Shanghai, China | $12.1 bn | $3.3 bn |
| 82 | Tianjin Pharma | Tianjin, China | $12 bn | $3.3 bn |
| 83 | R-Pharm | Moscow, Russia | $11.9 bn | $1.8 bn |
| 84 | Grupo Insud | Madrid, Spain | $11.7 bn | $1.7 bn |
| 85 | Adimab | Lebanon, NH, US | $11.4 bn | NA |
| 86 | LEO Pharma | Copenhagen, Denmark | $11.4 bn | $1.7 bn |
| 87 | SK Biopharma | Seoul, Korea | $11 bn | $5.2 mn |
| 88 | Grunenthal | Aachen, Germany | $10.9 bn | $1.6 bn |
| 89 | Roemmers | Argentina | $10.8 bn | $3 bn |
| 90 | Innovent Biologics | Jiangsu Province, China | $10.5 bn | $238 mn |
| 91 | Vifor Pharma | St. Gallen, Switzerland | $10.2 bn | $2 bn |
| 92 | Bracco | Milan, Italy | $10.1 bn | $1.5 bn |
| 93 | Dr. Reddy’s | Hyderabad, India | $10.1 bn | $2.3 bn |
| 94 | Junshi Biosciences | Jiangsu Province, China | $10 bn | $147 mn |
| 95 | Ibsen | Paris, France | $10 bn | $3 bn |
| 96 | Roivant Sciences | New York Area, US | $10 bn | NA |
| 97 | Sarepta Therapeutics | Boston Area, US | $9.9 bn | $450 mn |
| 98 | Harbin Pharma | Heilongjiang Province, China | $9.7 bn | $2.7 bn |
| 99 | CureVac | Tubingen, Germany | $9.6 bn | $19 mn |
| 100 | Ceva Sante Animale | Dusseldorf, Germany | $9.3 bn | $1.4 bn |
| 101 | Neurocrine Biosciences | San Diego, US | $9.3 bn | $1 bn |
| 102 | Gan & Lee Pharma | Beijing, China | $9.3 bn | $445 mn |
| 103 | argenx | Netherlands | $8.8 bn | $70 mn |
| 104 | Humanwell Healthcare | Hubei Province, China | $8.8 bn | $2.9 bn |
| 105 | Sobi | Sweden | $8.7 bn | $1.6 bn |
| 106 | CR Pharma Rx Segment | Hong Kong | $8.6 bn | $4.3 bn |
| 107 | Hetero Drugs | Hyderabad, India | $8.6 bn | $2.3 bn |
| 108 | Merz | Hessen, Germany | $8.5 bn | $1.2 bn |
| 109 | Hikma | London, United Kingdom | $8.4 bn | $2.2 bn |
| 110 | Kangmei Pharma | Guangdong Province, China | $8.4 bn | $825 mn |
| 111 | Jazz Pharma | Bay Area, US | $8.4 bn | $2.2 bn |
| 112 | Huahai Pharma | Zhejiang Province, China | $8.4 bn | $855 mn |
| 113 | Cipla | Mumbai, India | $8.3 bn | $2.3 bn |
| 114 | Serum Institute of India | Pune, India | $8.3 bn | $819 mn |
| 115 | Baxter Pharma | Chicago Area | $8.2 bn | $2.2 bn |
| 116 | Shanghai RAAS | Shanghai, China | $8.2 bn | $367 mn |
| 117 | CanSino Biologics | Tianjin, China | $8.2 bn | $2.2 mn |
| 118 | Alfasigma | Florence, Italy | $8.2 bn | $1.2 bn |
| 119 | Mitsubishi Tanabe | Osaka, Japan | $8 bn | $3.8 bn |
| 120 | Lundbeck | Copenhagen, Denmark | $7.8 bn | $2.6 bn |
| 121 | Tiantan Biological | Beijing, China | $7.5 bn | $463 mn |
| 122 | Endo International | New York Area, US | $7.3 bn | $3 bn |
| 123 | Biocon | Bangalore, India | $7.3 bn | $871 mn |
| 124 | Torrent Pharma | Ahmedabad, India | $7.3 bn | $1 bn |
| 125 | Apotex | Toronto Area, Canada | $7.3 bn | $2 bn |
| 126 | STADA | Bad Vilbel, Germany | $7.2 bn | $3.1 bn |
| 127 | Ascendis Pharma | Copenhagen, Denmark | $7.1 bn | $9.4 mn |
| 128 | Santen | Osaka, Japan | $7.1 bn | $2.2 bn |
| 129 | Angelini | Rome, Italy | $7 bn | $1 bn |
| 130 | Schwabe | Stutensee, Germany | $7 bn | $1 bn |
| 131 | Aurobindo | Hyderabad, India | $6.9 bn | $3.1 bn |
| 132 | Betta Pharm | Zhejiang Province, China | $6.8 bn | $246 mn |
| 133 | Intas Pharma | Ahmedabad, India | $6.6 bn | $1.8 bn |
| 134 | Exelixis | Bay Area, US | $6.6 bn | $998 mn |
| 135 | Ache Laboratorios | Guarulhos, Brazil | $6.6 bn | $1 bn |
| 136 | Unilab | Philippines | $6.6 bn | $1 bn |
| 137 | Dainippon Sumitomo | Osaka, Japan | $6.6 bn | $4.6 bn |
| 138 | Orion | Finland | $6.5 bn | $1.2 bn |
| 139 | Lupin | Mumbai, India | $6.4 bn | $1.9 bn |
| 140 | Huadong Medicine | Zhejiang Province, China | $6.4 bn | $4.7 bn |
| 141 | Mirati Therapeutics | San Diego, US | $6.4 bn | $1.7 mn |
| 142 | Zydus Cadila | Ahmedabad, India | $6.3 bn | $1.9 bn |
| 143 | Kedrion | Florence, Italy | $6.3 bn | $953 mn |
| 144 | King-Friend Bio | Jiangsu Province, China | $6.2 bn | $380 mn |
| 145 | Shin Poong | South Korea | $6.2 bn | $164 mn |
| 146 | lonis | San Diego, US | $6.1 bn | $940 mn |
| 147 | Emergent BioSolutions | Gaithersburg, MD, US | $6 bn | $1.2 bn |
| 148 | Green Valley Pharma | Shanghai, China | $5.9 bn | $900 mn |
| 149 | Guangzhou Pharma | Guangdong Province, China | $5.9 bn | $8.7 bn |
| 150 | MyoKardia | Bay Area, US | $5.9 bn | NA |
| 151 | Momenta | Boston Area, US | $5.8 bn | $30 mn |
| 152 | Kanghong Pharma | Sichuan Province, China | $5.8 bn | $443 mn |
| 153 | Acceleron | Boston Area, US | $5.7 bn | $87 mn |
| 154 | Novavax | Gaithersburg, MD, US | $5.7 bn | $50 mn |
| 155 | Aspen Pharmacare | South Africa | $5.7 bn | $2.2 bn |
| 156 | Italfarmaco | Milan, Italy | $5.7 bn | $856 mn |
| 157 | Zambon | Milan, Italy | $5.6 bn | $853 mn |
| 158 | Maruho | Osaka, Japan | $5.6 bn | $847 mn |
| 159 | ACADIA Pharma | San Diego, US | $5.5 bn | $393 mn |
| 160 | Zai Lab | Shanghai China | $5.5 bn | $28 mn |
| 161 | Youcare Pharma | Beijing, China | $5.4 bn | $1.5 bn |
| 162 | Salubris Pharma | Guangdong Province, China | $5.4 bn | $516 mn |
| 163 | Nippon Shinyaku | Tokyo, Japan | $5.2 bn | $1.1 bn |
| 164 | Grupo Ferrer | Barcelona, Spain | $5.2 bn | $790 mn |
| 165 | Yifan Pharma | Zhejiang Province, China | $5.1 bn | $775 mn |
| 166 | CRISPR Therapeutics | Zug, Switzerland | $5.1 bn | $289 mn |
| 167 | PeptiDream | Kawasaki, Japan | $5.1 bn | $0 mn |
| 168 | Livzon | Guangdong Province, China | $5 bn | $1.3 bn |
| 169 | ALTEOGEN | South Korea | $5 bn | $36 mn |
| 170 | Tasly Pharma | Tianjin, China | $5 bn | $2.5 bn |
| 171 | Alkem | Mumbai, India | $4.8 bn | $1.1 bn |
| 172 | Kalbe | North Sumatra, Indonesia | $4.8 bn | $1.5 bn |
| 173 | Dechra Pharma | Northern UK | $4.7 bn | $637 mn |
| 174 | Mallinckrodt | London, United Kingdom | $4.5 bn | $2.3 bn |
| 175 | Chi-Med | Hong Kong | $4.5 bn | $209 mn |
| 176 | Laboratoires Thea | Clermont-Ferrand, France | $4.5 bn | $678 mn |
| 177 | lovance | Bay Area, US | $4.5 bn | NA |
| 178 | Samsung Bioepis | South Korea | $4.4 bn | $850 mn |
| 179 | Wolwo Pharma | Zhejiang Province, China | $4.4 bn | $88 mn |
| 180 | Dongbao Pharma | Jilin Province, China | $4.4 bn | $398 mn |
| 181 | Buchang Pharma | Shandong Province, China | $4.4 bn | $2.1 bn |
| 182 | Mega Pharma | Uruguay | $4.3 bn | $1.2 bn |
| 183 | Kanghua Biological | Sichuan Province, China | $4.3 bn | $104 mn |
| 184 | Yiling Pharma | Hebei Province, China | $4.3 bn | $1 bn |
| 185 | NCPC | Hebei Province, China | $4.3 bn | $1.5 bn |
| 186 | Abdi Ibrahim | Turkey | $4.2 bn | $639 mn |
| 187 | Jinyu Bio-Tech | Mongolia | $4.2 bn | $175 mn |
| 188 | CHEPLAPHARM | Pomerania, Germany | $4.2 bn | $1.1 bn |
| 189 | Ultragenyx | Bay Area, US | $4.2 bn | $159 mn |
| 190 | Allogene | Bay Area, US | $4.1 bn | NA |
| 191 | Meiji Pharma Business | Tokyo, Japan | $4.1 bn | $1.9 bn |
| 192 | Orifarm | Copenhagen, Denmark | $4 bn | $1.1 bn |
| 193 | Pharmstandard | Dolgoprudny, Russia | $4 bn | $1.1 bn |
| 194 | Grupo Bago | Argentina | $4 bn | $1.1 bn |
| 195 | Apeloa Pharma | Zhejiang Province, China | $4 bn | $1 bn |
| 196 | Polpharma | Poland | $3.9 bn | $1 bn |
| 197 | Idorsia | Basel, Switzerland | $3.9 bn | $72 mn |
| 198 | Oneness Biotech | Taiwan | $3.9 bn | $1.4 mn |
| 199 | Hisun Pharma | Zhejiang Province, China | $3.8 bn | $1.5 bn |
| 200 | Halozyme | San Diego, US | $3.8 bn | $180 mn |
| 201 | IBSA | Lugano, Switzerland | $3.8 bn | $572 mn |
| 202 | Celltrion Pharm | South Korea | $3.7 bn | $152 mn |
| 203 | neuraxpharm | Langenfeld, Germany | $3.7 bn | $566 mn |
| 204 | Hypera | Sao Paolo, Brazil | $3.7 bn | $694 mn |
| 205 | Ipca | Mumbai, India | $3.7 bn | $617 mn |
| 206 | Esteve | Barcelona, Spain | $3.7 bn | $556 mn |
| 207 | Biohaven | New York Area, US | $3.7 bn | $10 mn |
| 208 | Haisco | Sichuan Province, China | $3.7 bn | $498 mn |
| 209 | Gedeon Richter | Hungary | $3.6 bn | $1.7 bn |
| 210 | Relay Therapeutics | Boston Area, US | $3.6 bn | $0 mn |
| 211 | Legend Biotech | Jiangsu Province, China | $3.6 bn | $61 mn |
| 212 | Hanmi Pharm | South Korea | $3.6 bn | $917 mn |
| 213 | Barakat Pharmaceutical | Iran | $3.6 bn | $1 bn |
| 214 | Blueprint Medicines | Boston Area, US | $3.6 bn | $75 mn |
| 215 | Allakos | Bay Area, US | $3.6 bn | NA |
| 216 | ALK | Copenhagen, Denmark | $3.6 bn | $505 mn |
| 217 | LG Life Sciences | South Korea | $3.6 bn | $540 mn |
| 218 | JCR | Ashiya, Japan | $3.5 bn | $230 mn |
| 219 | Eurofarma | Sao Paolo, Brazil | $3.5 bn | $982 mn |
| 220 | Genexine | South Korea | $3.5 bn | $4.1 mn |
| 221 | ROHTO | Osaka, Japan | $3.5 bn | $1.7 bn |
| 222 | Besins | Monaco | $3.5 bn | $531 mn |
| 223 | Amicus Therapeutics | New York Area, US | $3.5 bn | $226 mn |
| 224 | Perrigo Rx Business | Allegan, MI, US | $3.5 bn | $968 mn |
| 225 | Denali Therapeutics | Bay Area, US | $3.5 bn | $27 mn |
| 226 | Kyoritsu Seiyaku | Tokyo, Japan | $3.5 bn | $524 mn |
| 227 | Zentiva | Czech Republic | $3.4 bn | $957 mn |
| 228 | Genus | London, United Kingdom | $3.4 bn | $682 mn |
| 229 | Amneal | New York Area, US | $3.4 bn | $1.7 bn |
| 230 | China Grand Pharma | Hong Kong | $3.4 bn | $807 mn |
| 231 | FibroGen | Bay Area, US | $3.4 bn | $108 mn |
| 232 | Vir Biotechnology | Bay Area, US | $3.4 bn | $75 mn |
| 233 | Dermapharm | Munich Area, Germany | $3.4 bn | $855 mn |
| 234 | Schrodinger | Bangalore, India | $3.4 bn | $95 mn |
| 235 | Dompe | Milan, Italy | $3.3 bn | $507 mn |
| 236 | Luoxin Pharma | Shandong Province, China | $3.3 bn | $897 mn |
| 237 | MorphoSys | Munich Area, Germany | $3.3 bn | $329 mn |
| 238 | Shafadarou Investment | Iran | $3.3 bn | $906 mn |
| 239 | Norgine | Netherlands | $3.3 bn | $494 mn |
| 240 | AnkeBio | Anhui Province, China | $3.3 bn | $235 mn |
| 241 | Yuhan | South Korea | $3.2 bn | $1.2 bn |
| 242 | Macleods Pharma | Mumbai, India | $3.2 bn | $891 mn |
| 243 | PROBIOMED | Mexico | $3.2 bn | $317 mn |
| 244 | Dr. Falk Pharma | Freiburg im Breisgau, Germany | $3.2 bn | $485 mn |
| 245 | ChemoCentryx | Bay Area, US | $3.2 bn | $76 mn |
| 246 | Arrowhead Pharma | Los Angeles, US | $3.2 bn | $123 mn |
| 247 | Taisho Pharma | Tokyo, Japan | $3.2 bn | $2.8 bn |
| 248 | Pars Darou | Iran | $3.2 bn | $881 mn |
| 249 | China Meheco Group | Beijing, China | $3.2 bn | $5.2 bn |
| 250 | China Biologic Products | Beijing, China | $3.1 bn | $511 mn |
| 251 | Bridgebio Pharma | Bay Area, US | $3.1 bn | $40 mn |
| 252 | LFB | Paris, France | $3.1 bn | $472 mn |
| 253 | PTC Therapeutics | New York Area, US | $3.1 bn | $311 mn |
| 254 | Immunovant | New York Area, US | $3.1 bn | NA |
| 255 | lnsmed | New York Area, US | $3.1 bn | $163 mn |
| 256 | Asahi Kasei Pharma | Tokyo, Japan | $3.1 bn | NA |
| 257 | GC Pharma | South Korea | $3 bn | $1.1 bn |
| 258 | BrightGene Bio | Jiangsu Province, China | $3 bn | $84 mn |
| 259 | medac gmbh | Wedel, Germany | $2.9 bn | $446 mn |
| 260 | 3SBio | Liaoning Province, China | $2.9 bn | $760 mn |
| 261 | Amoytop Biotech | Fujian Province, China | $2.9 bn | $109 mn |
| 262 | United Therapeutics | Silver Spring MD, US | $2.9 bn | $1.4 bn |
| 263 | GBT | Bay Area, US | $2.9 bn | $47 mn |
| 264 | GW Pharmaceuticals | Cambridge, UK | $2.9 bn | $441 mn |
| 265 | Arena Pharma | San Diego, US | $2.9 bn | $4.6 mn |
| 266 | Alvogen | New York Area, US | $2.9 bn | $800 mn |
| 267 | Prasco | Mason, Ohio, US | $2.9 bn | $800 mn |
| 268 | Simcere Pharma | Jiangsu Province, China | $2.9 bn | $800 mn |
| 269 | ADC Therapeutics | Geneva, Switzerland | $2.9 bn | $0 mn |
| 270 | Axsome | New York, NY | $2.9 bn | NA |
| 271 | BIOCAD | St. Petersburg, Russia | $2.9 bn | $283 mn |
| 272 | Guojian Pharma | Shanghai, China | $2.8 bn | $149 mn |
| 273 | KrKa | Slovenia | $2.8 bn | $1.7 bn |
| 274 | Chipscreen | Guangdong Province, China | $2.8 bn | $28 mn |
| 275 | Harmony Biosciences | Philadelphia Area, US | $2.8 bn | $63 mn |
| 276 | Fate Therapeutics | San Diego, US | $2.8 bn | $13 mn |
| 277 | Reata Pharma | Irving, TX, US | $2.8 bn | $13 mn |
| 278 | Hisamitsu | Tosu, Japan | $2.8 bn | $1.2 bn |
| 279 | China Medical System | Guangdong Province, China | $2.8 bn | $880 mn |
| 280 | Biolab Sanus Pharma | Sao Paolo, Brazil | $2.8 bn | $418 mn |
| 281 | Biolab Sanus Pharma | Sao Paolo, Brazil | $2.8 bn | $418 mn |
| 282 | Mankind Pharma | Delhi, India | $2.8 bn | $766 mn |
| 283 | Sawai | Osaka, Japan | $2.7 bn | $1.6 bn |
| 284 | Jubilant Pharma Segment | Noida, UP, India | $2.7 bn | $758 mn |
| 285 | TG Therapeutics | New York Area, US | $2.7 bn | $0.1 mn |
| 286 | Ethypharm | Paris, France | $2.7 bn | $413 mn |
| 287 | China TCM Holdings | Hong Kong | $2.7 bn | $1.9 bn |
| 288 | Kowa Pharma Segment | Tokyo, Japan | $2.7 bn | $1.3 bn |
| 289 | Alembic | Ahmedabad, India | $2.7 bn | $661 mn |
| 290 | Alkermes | Boston Area, US | $2.7 bn | $1.1 bn |
| 291 | Nektar | Bay Area, US | $2.7 bn | $162 mn |
| 292 | Neopharm Ltd | Israel | $2.6 bn | $400 mn |
| 293 | AoDong Medicine | Jilin Province, China | $2.6 bn | $363 mn |
| 294 | Chase Sun Pharma | Tianjin, China | $2.6 bn | $778 mn |
| 295 | Akeso | Guangdong Province, China | $2.6 bn | $10 mn |
| 296 | Joincare Pharma | Guangdong Province, China | $2.6 bn | $1.7 bn |
| 297 | Turning Point | San Diego, US | $2.6 bn | NA |
| 298 | Pacira | New York Area, US | $2.6 bn | $408 mn |
| 299 | Dendreon / Sanpower | Los Angeles, US | $2.6 bn | $393 mn |
| 300 | Bio-Thera Solutions | Guangdong Province, China | $2.6 bn | $7 mn |
| 301 | Zelgen Bio | Anhui Province, China | $2.6 bn | NA |
| 302 | Jumpcan Pharma | Jiangsu Province, China | $2.6 bn | $847 mn |
| 303 | Luye Pharma | Shandong Province, China | $2.5 bn | $876 mn |
| 304 | Shuanglin Biopharma | Guangdong Province, China | $2.5 bn | $133 mn |
| 305 | Pharmascience | Quebec, Canada | $2.5 bn | $700 mn |
| 306 | Almirall | Barcelona, Spain | $2.5 bn | $981 mn |
| 307 | Karo Pharma | Sweden | $2.5 bn | $276 mn |
| 308 | Ocumension | Jiangsu Province, China | $2.5 bn | $0.3 mn |
| 309 | Fudan-Zhangjiang | Shanghai China | $2.5 bn | $123 mn |
| 310 | Emcure | Mumbai, India | $2.4 bn | $673 mn |
| 311 | OPKO Health | Miami, Florida, US | $2.4 bn | $965 mn |
| 312 | Seres Therapeutics | Boston Area, US | $2.4 bn | $28 mn |
| 313 | Xianju Pharma | Zhejiang Province, China | $2.4 bn | $512 mn |
| 314 | Tsumura | Osaka, Japan | $2.4 bn | $1.1 bn |
| 315 | Boya Bio | Jiangxi Province, China | $2.4 bn | $404 mn |
| 316 | Galapagos | Belgium | $2.4 bn | $1.1 bn |
| 317 | Teijin Pharma | Tokyo, Japan | $2.3 bn | $1.1 bn |
| 318 | Fidia Farma | Abano Terme, Italy | $2.3 bn | $354 mn |
| 319 | Glenmark | Mumbai, India | $2.3 bn | $1.4 bn |
| 320 | CytoDyn | Seattle, US | $2.3 bn | NA |
| 321 | Sage Therapeutics | Boston Area, US | $2.3 bn | $8.9 mn |
| 322 | Biocodex | Paris, France | $2.3 bn | $350 mn |
| 323 | Helsinn | Lugano, Switzerland | $2.3 bn | $350 mn |
| 324 | Deciphera | Boston Area, US | $2.3 bn | $7.1 mn |
| 325 | Virbac | Carros, France | $2.3 bn | $1 bn |
| 326 | Conba Pharma | Zhejiang Province, China | $2.3 bn | $893 mn |
| 327 | BIAL | Portugal | $2.3 bn | $345 mn |
| 328 | Zhejiang Medicine | Zhejiang Province, China | $2.3 bn | $989 mn |
| 329 | Adamed | Poland | $2.3 bn | $343 mn |
| 330 | ASK Pharm | Jiangsu Province, China | $2.2 bn | $526 mn |
| 331 | Hile Bio-Technology | Shanghai, China | $2.2 bn | $36 mn |
| 332 | China Animal Husbandry | Beijing, China | $2.2 bn | $644 mn |
| 333 | bluebird bio | Boston Area, US | $2.2 bn | $239 mn |
| 334 | Liomont | Mexico | $2.2 bn | $600 mn |
| 335 | Stallergenes Greer | London, United Kingdom | $2.2 bn | $326 mn |
| 336 | Haiyao | Hainan Province, China | $2.1 bn | $298 mn |
| 337 | Bailing Group Pharma | Guizhou, China | $2.1 bn | $393 mn |
| 338 | Aristo Pharma | Berlin, Germany | $2.1 bn | $590 mn |
| 339 | Nhwa Pharma | Jiangsu Province, China | $2.1 bn | $500 mn |
| 340 | Huvepharma | Bulgaria | $2.1 bn | $320 mn |
| 341 | PharmaMar | Madrid, Spain | $2.1 bn | $240 mn |
| 342 | Aimmune Therapeutics | Bay Area, US | $2.1 bn | $0.5 mn |
| 343 | Xinbang Pharma | Guizhou, China | $2.1 bn | $860 mn |
| 344 | Haohai Biotech | Shanghai, China | $2.1 bn | NA |
| 345 | Myovant Sciences | Bay Area, US | $2 bn | $33 mn |
| 346 | ROVI | Madrid, Spain | $2 bn | $444 mn |
| 347 | SSY Group | Hong Kong | $2 bn | $528 mn |
| 348 | Norbrook Laboratories | Northern Ireland, UK | $2 bn | $305 mn |
| 349 | Intra-Cellular Therapies | New York Area, US | $2 bn | $3 mn |
| 350 | lnovio Pharma | Philadelphia Area, US | $2 bn | $2.7 mn |
| 351 | Mesoblast | Melbourne, Australia | $2 bn | $32 mn |
| 352 | Micro Labs | Bangalore, India | $2 bn | $558 mn |
| 353 | Cheezheng Tibetan Med | Nyingchi, Tibet, China | $2 bn | $198 mn |
| 354 | Agios | Boston Area, US | $2 bn | $185 mn |
| 355 | Kodiak Sciences | Palo Alto, CA | $1.9 bn | NA |
| 356 | Taiji Group | Sichuan Province, China | $1.9 bn | $1.5 bn |
| 357 | Revance | Bay Area, US | $1.9 bn | $0.4 mn |
| 358 | Apellis Pharma | Boston Area, US | $1.9 bn | NA |
| 359 | Natco | Hyderabad, India | $1.9 bn | $262 mn |
| 360 | MSN Laboratories | Hyderabad, India | $1.9 bn | $520 mn |
| 361 | Karuna Therapeutics | Boston Area, US | $1.9 bn | NA |
| 362 | Sorrento Therapeutics | San Diego, US | $1.9 bn | $35 mn |
| 363 | IGM Biosciences | Bay Area, US | $1.9 bn | NA |
| 364 | Shyndec | Shanghai, China | $1.8 bn | $1.7 bn |
| 365 | CK Life Sciences | Hong Kong | $1.8 bn | $612 mn |
| 366 | Bukwang Pharma | South Korea | $1.8 bn | $142 mn |
| 367 | Ironwood Pharma | Boston Area, US | $1.8 bn | $426 mn |
| 368 | Advanz Pharma | London, United Kingdom | $1.8 bn | $503 mn |
| 369 | Medochemie | Cyprus | $1.8 bn | $500 mn |
| 370 | Brilliant Pharma | Sichuan Province, China | $1.8 bn | $500 mn |
| 371 | Grupo Uriach | Barcelona, Spain | $1.8 bn | $271 mn |
| 372 | Square Pharma | Bangladesh | $1.8 bn | $545 mn |
| 373 | Acino | Zurich, Switzerland | $1.8 bn | $495 mn |
| 374 | Zhongheng Group | Guangxi Province, China | $1.8 bn | $530 mn |
| 375 | Ajanta Pharma | Mumbai, India | $1.8 bn | $350 mn |
| 376 | Xencor | Los Angeles, US | $1.8 bn | $70 mn |
| 377 | SL Pharm | Hainan Province, China | $1.7 bn | $214 mn |
| 378 | Hisoar Pharma | Zhejiang Province, China | $1.7 bn | $356 mn |
| 379 | Xiangxue Pharma | Guangdong Province, China | $1.7 bn | $464 mn |
| 380 | Eidos Therapeutics | Bay Area, US | $1.7 bn | $26 mn |
| 381 | ZBD Pharmaceutical | Heilongjiang Province, China | $1.7 bn | $450 mn |
| 382 | IDT Biologika | Dessau-Roillau, Germany | $1.7 bn | $259 mn |
| 383 | Siam Bioscience | Thailand | $1.7 bn | $169 mn |
| 384 | JT Pharma / Torii | Tokyo, Japan | $1.7 bn | $815 mn |
| 385 | Theramex | London, United Kingdom | $1.7 bn | $258 mn |
| 386 | HIPRA | Spain, Other | $1.7 bn | $256 mn |
| 387 | Zhongsheng Pharma | Guangdong Province, China | $1.7 bn | $284 mn |
| 388 | Quantum Hi-Tech | Guangdong Province, China | $1.7 bn | $195 mn |
| 389 | Biotest / Creat Group | Berlin, Germany | $1.7 bn | $516 mn |
| 390 | Sebela Pharma | Atlanta, US | $1.7 bn | $250 mn |
| 391 | Tecnoquimicas | Colombia | $1.6 bn | $458 mn |
| 392 | Corcept Therapeutics | Bay Area, US | $1.6 bn | $351 mn |
| 393 | SINQI | Liaoning Province, China | $1.6 bn | $74 mn |
| 394 | Towa Pharma | Osaka, Japan | $1.6 bn | $1.1 bn |
| 395 | Nichi-Iko | Toyama, Japan | $1.6 bn | $1.7 bn |
| 396 | Kolmar Medicine Unit | South Korea | $1.6 bn | $567 mn |
| 397 | Hugel | South Korea | $1.6 bn | $162 mn |
| 398 | Alphamab Oncology | Jiangsu Province, China | $1.6 bn | $1.4 mn |
| 399 | Aurinia Pharma | Vancouver, Canada | $1.6 bn | $0.3 mn |
| 400 | AnGes | Osaka, Japan | $1.6 bn | $1.5 mn |
| 401 | USV | Mumbai, India | $1.6 bn | $446 mn |
| 402 | Arkopharma | Lyon, France | $1.6 bn | $241 mn |
| 403 | Kimia Farma | Sumatera Utara, Indonesia | $1.6 bn | $662 mn |
| 404 | Bavarian Nordic | Copenhagen, Denmark | $1.6 bn | $226 mn |
| 405 | Dezhan Healthcare | Beijing, China | $1.6 bn | $221 mn |
| 406 | SpringWorks | New York Area, US | $1.6 bn | NA |
| 407 | Zixin Pharma | Jilin Province, China | $1.6 bn | $65 mn |
| 408 | HanAll Biopharma | South Korea | $1.6 bn | $82 mn |
| 409 | Cytokinetics | Bay Area, US | $1.6 bn | $18 mn |
| 410 | Gebro Pharma | Austria | $1.6 bn | $236 mn |
| 411 | Clinigen | Northern UK | $1.5 bn | $624 mn |
| 412 | Revolution Medicines | Bay Area, US | $1.5 bn | $46 mn |
| 413 | Isdin | Barcelona, Spain | $1.5 bn | $232 mn |
| 414 | Laboratorio Elea | Argentina | $1.5 bn | $232 mn |
| 415 | ALX Oncology | Bay Area, US | $1.5 bn | $3.6 mn |
| 416 | Forma Therapeutics | Boston Area, US | $1.5 bn | $10 mn |
| 417 | FujiFilm Pharma | Tokyo, Japan | $1.5 bn | NA |
| 418 | Laboratorios Sanfer | Mexico | $1.5 bn | NA |
| 419 | Sanovel | Turkey | $1.5 bn | $227 mn |
| 420 | SPIMACO | Mosadia, Saudi Arabia | $1.5 bn | $417 mn |
| 421 | Abiogen Pharma | Pisa, Italy | $1.5 bn | $223 mn |
| 422 | Akcea Therapeutics | Boston Area, US | $1.5 bn | $336 mn |
| 423 | uniQure | Netherlands | $1.5 bn | $5.3 mn |
| 424 | Innocare | Hong Kong | $1.5 bn | $0.1 mn |
| 425 | Microgen | Moscow, Russia | $1.5 bn | $144 mn |
| 426 | Intercept Pharma | New York Area, US | $1.5 bn | $283 mn |
| 427 | Zymeworks | Vancouver, Canada | $1.4 bn | $30 mn |
| 428 | Sobhan Pharma | Iran | $1.4 bn | $397 mn |
| 429 | Viela Bio | Gaithersburg, MD, US | $1.4 bn | $30 mn |
| 430 | Bimeda Animal Health | Ireland | $1.4 bn | $216 mn |
| 431 | Y-mAbs Therapeutics | New York Area, US | $1.4 bn | NA |
| 432 | Northeast Pharma | Shenyang Province, China | $1.4 bn | $1.1 bn |
| 433 | Sunflower Pharma | Heilongjiang Province, China | $1.4 bn | $507 mn |
| 434 | Biological E. | Hyderabad, India | $1.4 bn | $140 mn |
| 435 | Editas Medicine | Boston Area, US | $1.4 bn | $32 mn |
| 436 | Cortexyme | Bay Area, US | $1.4 bn | NA |
| 437 | Yungjin Pharm | South Korea | $1.4 bn | $147 mn |
| 438 | Kymera | Boston Area, US | $1.4 bn | NA |
| 439 | Lukang Pharma | Shandong Province, China | $1.4 bn | $549 mn |
| 440 | AlloVir | Boston Area, US | $1.4 bn | $0 mn |
| 441 | Hybio Pharma | Guangdong Province, China | $1.4 bn | $85 mn |
| 442 | URSAPHARM | Saarbrucken, Germany | $1.4 bn | $206 mn |
| 443 | Uniao Qufmica | Sao Paolo, Brazil | $1.4 bn | $376 mn |
| 444 | HEC Pharma | Guangdong Province, China | $1.4 bn | $741 mn |
| 445 | Zhongxin Pharma | Tianjin, China | $1.3 bn | $955 mn |
| 446 | MacroGenics | Rockville MD, US | $1.3 bn | $77 mn |
| 447 | Kern Pharma | Barcelona, Spain | $1.3 bn | $368 mn |
| 448 | Medison | Israel | $1.3 bn | $200 mn |
| 449 | Theravance Biopharma | Bay Area, US | $1.3 bn | $76 mn |
| 450 | Cosmo Pharma | Lugano, Switzerland | $1.3 bn | $75 mn |
| 451 | Nestle Pharma Ops | Vevey, Switzerland | $1.3 bn | $288 mn |
| 452 | Cerevel Therapeutics | Boston Area, US | $1.3 bn | NA |
| 453 | Atnahs | London, United Kingdom | $1.3 bn | $360 mn |
| 454 | Compugen | Israel | $1.3 bn | NA |
| 455 | Coherus | Bay Area, US | $1.3 bn | $487 mn |
| 456 | Mersana | Boston Area, US | $1.3 bn | $1.6 mn |
| 457 | II-Yang Pharm. | South Korea | $1.3 bn | $270 mn |
| 458 | Kura Oncology | San Diego, US | $1.3 bn | NA |
| 459 | Madrigal Pharma | Philadelphia Area, US | $1.3 bn | NA |
| 460 | GNI Group | Tokyo, Japan | $1.3 bn | $77 mn |
| 461 | KUP | South Korea | $1.2 bn | $136 mn |
| 462 | Weiguang Biological | Guangdong Province, China | $1.2 bn | $122 mn |
| 463 | Changshan Bio | Hebei Province, China | $1.2 bn | $308 mn |
| 464 | Nordic Pharma | Paris, France | $1.2 bn | $182 mn |
| 465 | Ringpu BioTech | Hebei Province, China | $1.2 bn | $245 mn |
| 466 | Renata | Bangladesh | $1.2 bn | $310 mn |
| 467 | Gloria Pharmaceuticals | Heilongjiang Province, China | $1.2 bn | $527 mn |
| 468 | Zealand Pharma | Copenhagen, Denmark | $1.2 bn | $38 mn |
| 469 | Medy-Tox | South Korea | $1.2 bn | $151 mn |
| 470 | Beam Therapeutics | Boston Area, US | $1.2 bn | NA mn |
| 471 | Ligand | San Diego, US | $1.2 bn | $126 mn |
| 472 | Leadiant Biosciences | Rome, Italy | $1.2 bn | $180 mn |
| 473 | Zhenghai Biotech | Shandong Province, China | $1.2 bn | $39 mn |
| 474 | Reliance Life Sciences | Mumbai, India | $1.2 bn | $116 mn |
| 475 | Nkarta | Bay Area, US | $1.2 bn | $0 mn |
| 476 | GuangYuYuang | Shaanxi Province, China | $1.2 bn | $156 mn |
| 477 | Mayinglong Pharma | Hubei Province, China | $1.2 bn | $341 mn |
| 478 | Zeria Pharma | Tokyo, Japan | $1.2 bn | $543 mn |
| 479 | Laboratoire Aguettant | Lyon, France | $1.2 bn | $177 mn |
| 480 | Adaptimmune | Oxford, UK | $1.2 bn | $2.2 mn |
| 481 | Duchesnay | Quebec, Canada | $1.2 bn | $175 mn |
| 482 | Mezzion | South Korea | $1.2 bn | $17 mn |
| 483 | Rocket Pharma | New York Area, US | $1.2 bn | NA |
| 484 | Akero Therapeutics | Bay Area, US | $1.2 bn | NA |
| 485 | Alvotech | Iceland | $1.2 bn | NA |
| 486 | Kanion Pharma | Jiangsu Province, China | $1.1 bn | $545 mn |
| 487 | Hansa BioPharma | Lund, Sweden | $1.1 bn | $0.3 mn |
| 488 | Synthon | Netherlands | $1.1 bn | $316 mn |
| 489 | Innoviva | Bay Area, US | $1.1 bn | $299 mn |
| 490 | Heron Therapeutics | San Diego, US | $1.1 bn | $125 mn |
| 491 | Athenex | New York Area, US | $1.1 bn | $140 mn |
| 492 | SAIDAL | Algeria | $1.1 bn | $313 mn |
| 493 | Faes Farma | Madrid, Spain | $1.1 bn | $458 mn |
| 494 | VTR Bio-tech | Guangdong Province, China | $1.1 bn | $298 mn |
| 495 | Helixsmith | South Korea | $1.1 bn | $4.4 mn |
| 496 | Amarin | New York Area, US | $1.1 bn | $545 mn |
| 497 | Haw Par Corporation | Singapore | $1.1 bn | $130 mn |
| 498 | Sam Chun Dang Pharm | South Korea | $1.1 bn | $152 mn |
| 499 | Rhythm Pharma | Boston Area, US | $1.1 bn | NA |
| 500 | iTeos Therapeutics | Boston Area, US | $1.1 bn | $0 mn |
| 501 | Strides | Bangalore, India | $1.1 bn | $377 mn |
| 502 | Kyorin | Tokyo, Japan | $1.1 bn | $1 bn |
| 503 | Kaken Pharma | Tokyo, Japan | $1.1 bn | $788 mn |
| 504 | Epizyme | Boston Area, US | $1.1 bn | $13 mn |
| 505 | Nurix Therapeutics | Bay Area, US | $1.1 bn | $19 mn |
| 506 | Camurus | Lund, Sweden | $1.1 bn | $22 mn |
| 507 | Arbor Pharma | Atlanta, US | $1.1 bn | $300 mn |
| 508 | Stendhal Pharma | Mexico | $1.1 bn | $300 mn |
| 509 | Chengdu Baiyu | Sichuan Province, China | $1.1 bn | $300 mn |
| 510 | Pulike Biological | Henan Province, China | $1.1 bn | $108 mn |
| 511 | Bharat Biotech | Hyderabad, India | $1.1 bn | $106 mn |
| 512 | Phibro Animal Health | New York Area, US | $1.1 bn | $800 mn |
| 513 | Vianex | Greece | $1.1 bn | $297 mn |
| 514 | Mithra | Belgium | $1.1 bn | $108 mn |
| 515 | LACER | Barcelona, Spain | $1.1 bn | $162 mn |
| 516 | Mayoly Spindler | Paris, France | $1.1 bn | $161 mn |
| 517 | Lummy Pharma | Sichuan Province, China | $1.1 bn | $235 mn |
| 518 | DONGKOOK Pharma | South Korea | $1.1 bn | $433 mn |
| 519 | TECNIMEDE | Portugal | $1 bn | $290 mn |
| 520 | Oscotec | South Korea | $1 bn | $15 mn |
| 521 | Eczacibasi Mac Sanayi | Levent, Turkey | $1 bn | $157 mn |
| 522 | Eurocept | Netherlands | $1 bn | $288 mn |
| 523 | IBI | Aprilia, Italy | $1 bn | $288 mn |
| 524 | Science Sun | Beijing, China | $1 bn | $161 mn |
| 525 | Cristalia | Sao Paolo, Brazil | $1 bn | $287 mn |
| 526 | Pharmicell | South Korea | $1 bn | $23 mn |
| 527 | Sanjin | Guangxi Province, China | $1 bn | $226 mn |
| 528 | Pharmathen | Netherlands | $1 bn | $285 mn |
| 529 | Precigen | Germantown MD, US | $1 bn | $95 mn |
| 530 | KPC | Yunnan Province, China | $1 bn | $1.1 bn |
| 531 | Jiuzhitang | Hubei Province, China | $1 bn | $471 mn |
| 532 | C Labs | Madrid, Spain | $1 bn | $283 mn |
| 533 | Dr. Kade | Berlin, Germany | $1 bn | $154 mn |
| 534 | Generation Bio | Boston Area, US | $1 bn | $0 mn |
| 535 | BioXcel Therapeutics | New York Area, US | $1 bn | NA |
| 536 | Adimmune | Taiwan | $1 bn | $53 mn |
| 537 | Cadila Pharma | Ahmedabad, India | $1 bn | $280 mn |
| 538 | Sana | Seattle, US | $1 bn | NA |
| 539 | AYUMI Pharmaceutical | Tokyo, Japan | $1 bn | $239 mn |
| 540 | Adverum Biotechnologies | Bay Area, US | $1 bn | $0.2 mn |
| 541 | Karyopharm | Boston Area, US | $999 mn | $82 mn |
| 542 | Haixin Group | Shanghai, China | $998.3 mn | $146 mn |
| 543 | Lantheus | Boston Area, US | $997.3 mn | $331 mn |
| 544 | Zogenix | Bay Area, US | $994.7 mn | $4.8 mn |
| 545 | Tris Pharma | Monmouth Junction NJ, US | $990 mn | $150 mn |
| 546 | Zhejiang Int’l Group | Zhejiang Province, China | $989.3 mn | $3.6 bn |
| 547 | Annexon | Bay Area, US | $988.4 mn | $0 mn |
| 548 | Guanhao Biotech | Guangdong Province, China | $985.3 mn | $61 mn |
| 549 | Clovis Oncology | Colorado, U.S. | $983.4 mn | $159 mn |
| 550 | Bottu | Morocco | $981 mn | $272 mn |
| 551 | NGM Biopharmaceuticals | Bay Area, US | $979.7 mn | $96 mn |
| 552 | Normon | Madrid, Spain | $979.2 mn | $272 mn |
| 553 | Zentalis Pharma | New York Area, US | $974 mn | $0 mn |
| 554 | Pharscin Pharma | Sichuan Province, China | $971.8 mn | $115 mn |
| 555 | Oncopeptides | Sweden | $970.7 mn | NA |
| 556 | Huaren Pharma | Shandong Province, China | $968.4 mn | $189 mn |
| 557 | Fudan Forward | Shanghai, China | $964.2 mn | $139 mn |
| 558 | Wockhardt | Mumbai, India | $964.1 mn | $359 mn |
| 559 | Yipinhong Pharma | Guangdong Province, China | $960.8 mn | $214 mn |
| 560 | TerSera Therapeutics | Chicago Area | $957 mn | $145 mn |
| 561 | Eris Lifesciences Limited | Ahmedabad, India | $956.1 mn | $142 mn |
| 562 | Dexa Medica | Medan City, Indonesia | $951 mn | NA |
| 563 | Avidity Biosciences | San Diego, US | $949.2 mn | $4.9 mn |
| 564 | Tonghua Golden-Horse | Jilin Province, China | $943.7 mn | $213 mn |
| 565 | Shandong Shanda | Shandong Province, China | $941.4 mn | $257 mn |
| 566 | Sosei | Tokyo, Japan | $940.1 mn | $66 mn |
| 567 | Beijing Beilu Pharma | Beijing, China | $937.2 mn | $111 mn |
| 568 | Amphastar Pharma | Los Angeles, US | $936.9 mn | $334 mn |
| 569 | Takata Pharmaceutical | Saitama, Japan | $936 mn | NA |
| 570 | Tabuk Pharma | Riyadh, Saudi Arabia | $936 mn | $260 mn |
| 571 | Omeros | Seattle, US | $935 mn | $100 mn |
| 572 | Healios | Tokyo, Japan | $932.4 mn | $2.3 mn |
| 573 | Nippon Kayaku Pharma | Tokyo, Japan | $928 mn | $444mm |
| 574 | Kiniksa Pharma | Boston Area, US | $926.3 mn | NA |
| 575 | Boston Scientific Pharma | Boston Area, US | $924 mn | $140 mn |
| 576 | Renhe | Jiangxi Province, China | $921.5 mn | $577 mn |
| 577 | Applied Molecular Transp | Bay Area, US | $920.5 mn | $0 mn |
| 578 | Tai’an Tang Pharma | Shanghai, China | $918.6 mn | $547 mn |
| 579 | Arcus Biosciences | Bay Area, US | $914.1 mn | $15 mn |
| 580 | Arcturus Therapeutics | San Diego, US | $910.4 mn | $11 mn |
| 581 | Vetoquinol | Paris, France | $906.1 mn | $444 mn |
| 582 | JW Holdings | South Korea | $905.5 mn | $618 mn |
| 583 | Esperion | Ann Arbor, MI, US | $904.9 mn | $216 mn |
| 584 | Apsen | Sao Paolo, Brazil | $900 mn | $250 mn |
| 585 | Dexcel Pharma | Israel | $900 mn | $250 mn |
| 586 | Agenus | Boston Area, US | $897.9 mn | $96 mn |
| 587 | J. B. Chemicals | Mumbai, India | $897.5 mn | $245 mn |
| 588 | Jingxin Pharm | Zhejiang Province, China | $895.1 mn | $485 mn |
| 589 | Intellia Therapeutics | Boston Area, US | $894.5 mn | $50 mn |
| 590 | Mochida | Tokyo, Japan | $892.1 mn | $952 mn |
| 591 | Osiris | Columbia MD, US | $888.3 mn | $134 mn |
| 592 | SKK | Tokyo, Japan | $887.3 mn | $424 mn |
| 593 | Stoke Therapeutics, Inc. | Boston Area, US | $887 mn | NA |
| 594 | Ampharco U.S.A. | Nhon Trach, Vietnam | $885.5 mn | $245 mn |
| 595 | Oxford BioMedica | Oxford, UK | $885.1 mn | $81 mn |
| 596 | Shanghai Furen | Shanghai, China | $884.9 mn | $529 mn |
| 597 | Binex | South Korea | $884.1 mn | $107 mn |
| 598 | Daewoong | South Korea | $884 mn | $890 mn |
| 599 | Zhendong Pharma | Shanxi Province, China | $881.9 mn | $622 mn |
| 600 | Sangamo Therapeutics | Bay Area, US | $881.8 mn | $111 mn |
| 601 | TaiMed Biologics | Taiwan | $878.8 mn | $28 mn |
| 602 | PharmaEssentia | Taiwan | $877.2 mn | $11 mn |
| 603 | Jiangzhong Pharma | Jiangxi Province, China | $870.6 mn | $349 mn |
| 604 | Pharm-Sintez | Moscow, Russia | $865.8 mn | $240 mn |
| 605 | Dong-A Socio | South Korea | $860 mn | $659 mn |
| 606 | Jingfeng Pharma | Shanghai China | $858 mn | $172 mn |
| 607 | Jiudian Pharma | Changsha, China | $846.8 mn | $126 mn |
| 608 | Incepta Pharma | Bangladesh | $843.7 mn | $234 mn |
| 609 | Black Diamond Tx | Boston Area, US | $842.4 mn | NA |
| 610 | Immunocore | Oxford, UK | $839.4 mn | NA |
| 611 | Bosnalijek | Bosnia-Herzegovina | $837.7 mn | $232 mn |
| 612 | Bilim Pharmaceuticals | Turkey | $836.2 mn | $232 mn |
| 613 | Qianhong Biopharma | Jiangsu Province, China | $835.6 mn | $210 mn |
| 614 | Akorn | Chicago Area | $833 mn | $682 mn |
| 615 | Supernus | Rockville MD, US | $832.6 mn | $424 mn |
| 616 | Jinhe Biotech | Liaoning Province, China | $830.8 mn | $254 mn |
| 617 | Repare Therapeutics | Toronto, Canada | $830.4 mn | $0 mn |
| 618 | REGENXBIO | Rockville MD, US | $828.4 mn | $60 mn |
| 619 | Poseida Therapeutics | San Diego, US | $828.2 mn | $0 mn |
| 620 | Atara Biotherapeutics | Bay Area, US | $827.8 mn | NA |
| 621 | Beijing Tong Ren Tang | Hebei Province, China | $825.3 mn | $600 mn |
| 622 | Tong Ren Tang Tech | Beijing, China | $825.3 mn | $600 mn |
| 623 | Lingrui Pharma | Henan Province, China | $824.3 mn | $306 mn |
| 624 | Xinhua Pharm | Shandong Province, China | $823.7 mn | $816 mn |
| 625 | Cstone Pharma | Jiangsu Province, China | $822.9 mn | $3.2 mn |
| 626 | Chong Kun Dang Pharm | South Korea | $821.1 mn | $662 mn |
| 627 | Yoshindo | Toyama, Japan | $817 mn | $391 mn |
| 628 | Atea Pharma | Boston Area, US | $817 mn | NA |
| 629 | SanBio | Tokyo, Japan | $814 mn | $0.1 mn |
| 630 | Nihon Chouzai Generics | Tokyo, Japan | $808.8 mn | $2.5 bn |
| 631 | Laboratoires Brothier | Fontevraud-l’Abbaye, France | $805.8 mn | $223 mn |
| 632 | Bioiberica | Barcelona, Spain | $803.7 mn | $223 mn |
| 633 | Arvinas | New York Area, US | $802 mn | $46 mn |
| 634 | Jolly Pharmaceutical | Zhejiang Province, China | $801.4 mn | $134 mn |
| 635 | Pharmaceutical Associates | Washington DC Area | $800 mn | $100 mn |
| 636 | Collegium Pharmaceutical | Boston Area, US | $797.7 mn | $301 mn |
| 637 | Komipharm International | South Korea | $797.6 mn | $31 mn |
| 638 | Guidotti | Pisa, Italy | $797.1 mn | $221 mn |
| 639 | AOP Orphan | Austria | $794.3 mn | $120 mn |
| 640 | Zdrowie | Poland | $793 mn | $220 mn |
| 641 | Farmigea | Pisa, Italy | $790.2 mn | $119 mn |
| 642 | Vectura | London, United Kingdom | $784.2 mn | $218 mn |
| 643 | Keros Therapeutics | Boston Area, US | $782.5 mn | $5 mn |
| 644 | The GPO | Thailand | $779.7 mn | $216 mn |
| 645 | Tolmar / Tecnofarma | Colombia | $778.8 mn | $118 mn |
| 646 | Eusa Pharma | London, United Kingdom | $778.8 mn | $87 mn |
| 647 | Ji Yao Holding | Jilin Province, China | $774 mn | $9.5 bn |
| 648 | Laboratoire Renaudin | Itxassou, France | $772 mn | $214 mn |
| 649 | Lannett | Philadelphia Area, US | $771.9 mn | $545 mn |
| 650 | Yibai Pharmaceutical | Guizhou, China | $770 mn | $456 mn |
| 651 | BioArctic | Norway | $768.9 mn | $9.8 mn |
| 652 | Wohua Pharma | Shandong Province, China | $765.8 mn | $131 mn |
| 653 | Vericel | Boston Area, US | $765.7 mn | $116 mn |
| 654 | Havea Group | Bouffere, France | $764.6 mn | $212 mn |
| 655 | Prati, Donaduzzi & Cia. | Toledo, Brazil | $763.2 mn | $212 mn |
| 656 | Lionco Pharma | Zhejiang Province, China | $762.4 mn | $180 mn |
| 657 | Innovis Pharma | Greece | $760.3 mn | $211 mn |
| 658 | RAPT Therapeutics | Bay Area, US | $756.9 mn | $2.2 mn |
| 659 | Farmak | Kiev, Ukraine | $756 mn | $236 mn |
| 660 | Medis o.o.o. | Llubjana, Slovenia | $755.4 mn | $114 mn |
| 661 | Retrophin | San Diego, US | $754.5 mn | $187 mn |
| 662 | Kocak Farma | Istanbul, Turkey | $752.4 mn | $209 mn |
| 663 | Clinuvel Pharma | Zurich, Switzerland | $751.1 mn | $22 mn |
| 664 | VBI Vaccines | Boston Area, US | $749.5 mn | $1.8 mn |
| 665 | Replimune | Boston Area, US | $745 mn | NA |
| 666 | Pharming | Netherlands | $743.8 mn | $202 mn |
| 667 | Valenta Pharma | Moscow, Russia | $743.4 mn | $206 mn |
| 668 | Inhibrx | San Diego, US | $743.1 mn | NA |
| 669 | Desitin | Hamburg, Germany | $742.5 mn | $112 mn |
| 670 | CrystalGenomics | South Korea | $740.2 mn | $77 mn |
| 671 | FDC | Mumbai, India | $739.3 mn | $173 mn |
| 672 | Kai Bao Pharma | Shanghai, China | $739.1 mn | $156 mn |
| 673 | Blau Farmaceutica | Cotia, Brazil | $738.7 mn | $205 mn |
| 674 | Fatro | Milan, Italy | $735.9 mn | $111 mn |
| 675 | Arcutis Biotherapeutics | Los Angeles, US | $735.7 mn | NA |
| 676 | NantKwest | Los Angeles, US | $735.4 mn | NA |
| 677 | Translate Bio | Lexington, MA | $734.3 mn | $26 mn |
| 678 | SIFI | Sicily, Italy | $731.1 mn | $203 mn |
| 679 | Liminal BioSciences | Quebec, Canada | $729.1 mn | NA |
| 680 | Jiangsu Sihuan Bio | Jiangsu Province, China | $729 mn | $68 mn |
| 681 | Geropharm | Russia | $727.2 mn | $72 mn |
| 682 | Maruishi Pharma | Osaka, Japan | $726.3 mn | $347 mn |
| 683 | Currax Pharma | New York Area, US | $726 mn | $110 mn |
| 684 | Yabao Pharmaceutical | Shanxi Province, China | $722 mn | $370 mn |
| 685 | Exela Pharma | Lenoir, NC | $720 mn | $200 mn |
| 686 | Nippon Zoki | Osaka, Japan | $718.9 mn | $199 mn |
| 687 | Hengkang Medical | Sichuan Province, China | $716.6 mn | $437 mn |
| 688 | Senju Pharma | Osaka, Japan | $710.6 mn | $401 mn |
| 689 | Phathom Pharma | New York Area, US | $710.4 mn | NA |
| 690 | Cosunter | Fujian Province, China | $709.8 mn | $52 mn |
| 691 | Farabi Pharma | Iran | $709.2 mn | $197 mn |
| 692 | Teuto | Goias, Brazil | $705.6 mn | $196 mn |
| 693 | Acme Pharmaceuticals | Bangladesh | $704.5 mn | $195 mn |
| 694 | Julphar | United Arab Emirates | $703.8 mn | $102 mn |
| 695 | AB Science | Paris, France | $703.1 mn | $1.7 mn |
| 696 | Jinghua Pharma | Jiangsu Province, China | $698.9 mn | $159 mn |
| 697 | Dicerna Pharma | Boston Area, US | $692.1 mn | $89 mn |
| 698 | Boryung Pharma | South Korea | $689.9 mn | $456 mn |
| 699 | Beximco Pharma | Bangladesh | $689.9 mn | $295 mn |
| 700 | MiMedx | Atlanta, US | $687.8 mn | $280 mn |
| 701 | Staidson | Beijing, China | $686.8 mn | $68 mn |
| 702 | Emisphere Technologies | New York Area, US | $675.7 mn | $1 mn |
| 703 | Konruns Pharma | Beijing, China | $673.8 mn | $123 mn |
| 704 | Exir Pharmaceutical | Iran | $671 mn | $186 mn |
| 705 | DOC Generici | Milan, Italy | $669.6 mn | $186 mn |
| 706 | Radius | Boston Area, US | $669 mn | $200 mn |
| 707 | SillaJen | South Korea | $667.8 mn | $1.9 mn |
| 708 | Basilea | Basel, Switzerland | $667.6 mn | $148 mn |
| 709 | Vaxart | Bay Area, US | $667.3 mn | $7.7 mn |
| 710 | Pharmasyntez | Irkutsk, Russia | $666 mn | $185 mn |
| 711 | Cisen Pharmaceutical | Shandong Province, China | $663 mn | $539 mn |
| 712 | Tchaikapharma | Bulgaria | $662.3 mn | NA |
| 713 | MedDay Pharma | Paris, France | $660 mn | NA |
| 714 | Pharmacosmos | Copenhagen, Denmark | $660 mn | $100 mn |
| 715 | Eumedica | Belgium | $660 mn | $100 mn |
| 716 | Shilpa | Bangalore, India | $658.2 mn | $128 mn |
| 717 | Alector | Bay Area, US | $655.1 mn | $19 mn |
| 718 | Senhwa | Taiwan | $653.1 mn | NA |
| 719 | Dr. August Wolff | Bielefield, Germany | $649.5 mn | $98 mn |
| 720 | Cellectis | Paris, France | $648.2 mn | $73 mn |
| 721 | Kissei | Matsumoto, Japan | $647.1 mn | $586 mn |
| 722 | SPARC | Mumbai, India | $644.4 mn | $32 mn |
| 723 | Nobel | Turkey | $644.4 mn | $179 mn |
| 724 | Indofarma | Indonesia | $642.9 mn | $99 mn |
| 725 | Medigen Vaccine | Taiwan | $639.9 mn | NA |
| 726 | Flexion Therapeutics | Boston Area, US | $639.8 mn | $81 mn |
| 727 | Laboratoires Genevrier | Lyon, France | $639.4 mn | $96 mn |
| 728 | Kadmon | New York Area, US | $632.1 mn | $11 mn |
| 729 | Mayne Pharma | Melbourne, Australia | $624.6 mn | $315 mn |
| 730 | Morphic Therapeutics | Boston Area, US | $622.4 mn | $18 mn |
| 731 | Ozon Pharmaceuticals | Russia | $622 mn | $172 mn |
| 732 | OBI Pharma | Taiwan | $617.4 mn | $2 mn |
| 733 | Albireo Pharma | Boston Area, US | $616.9 mn | $11 mn |
| 734 | Sinovac | Beijing, China | $615 mn | $213 mn |
| 735 | Krystal Biotech | Pittsburgh Area, US | $614.6 mn | NA |
| 736 | Provention Bio, Inc. | New York Area, US | $614 mn | NA |
| 737 | ZENOAQ | Tokyo, Japan | $612.3 mn | $293 mn |
| 738 | Alora Pharma | Atlanta, US | $612 mn | $170 mn |
| 739 | Pliant Therapeutics | Bay Area, US | $608.7 mn | $89 mn |
| 740 | Sciclone | Shanghai, China | $605 mn | NA |
| 741 | Dynavax | Bay Area, US | $604.1 mn | $34 mn |
| 742 | Handok | South Korea | $602.5 mn | $405 mn |
| 743 | BioCryst | North Carolina, US | $602.3 mn | $49 mn |
| 744 | Weixinkang Medicine | Lhasa, Tibet, China | $601.2 mn | $95 mn |
| 745 | PKU HealthCare Corp. | Sichuan Province, China | $600.2 mn | $311 mn |
| 746 | Inozyme Pharma | Boston Area, US | $597.4 mn | $0 mn |
| 747 | Protagonist Therapeutics | Bay Area, US | $594.4 mn | $16 mn |
| 748 | HRA Pharma | New York Area, US | $594 mn | $90 mn |
| 749 | Molecular Templates | Austin, Texas | $592.7 mn | $20 mn |
| 750 | Boiron | Lyon, France | $590.4 mn | $623 mn |
| 751 | Nephron Pharma | West Columbia, SC | $589.3 mn | $163 mn |
| 752 | CCM Duopharma Biotech | Malaysia | $586.4 mn | $135 mn |
| 753 | Hiteck Biological Pharma | Wuhan, China | $585.7 mn | $69 mn |
| 754 | Deva Holding | Turkey | $585.4 mn | $230 mn |
| 755 | Laboraoires Majorelle | Paris, France | $583.2 mn | $30 mn |
| 756 | SOHO Global Healthcare | Indonesia | $578.8 mn | |
| 757 | Teikoku Senyaku | Higashikagawa, Japan | $576.8 mn | $276 mn |
| 758 | Alliance Pharma | London, United Kingdom | $571.8 mn | $162 mn |
| 759 | Caplin Point Laboratories | Chennai, India | $568.7 mn | $120 mn |
| 760 | Nativa | Russia | $567.3 mn | $157 mn |
| 761 | Cara Therapeutics | New York Area, US | $565.9 mn | $24 mn |
| 762 | Grupo Medinfar | Portugal | $565.4 mn | $157 mn |
| 763 | Gongwin Biopharm | Taiwan | $564.9 mn | NA |
| 764 | Cassiopea S.p.A. | Milan, Italy | $564.7 mn | $0.7 mn |
| 765 | Bath ASU | London, United Kingdom | $564.5 mn | $156 mn |
| 766 | Frequency Therapeutics | Boston Area, US | $563.9 mn | $44 mn |
| 767 | Foci Pharmaceutical | Gansu Province, China | $562.6 mn | $91 mn |
| 768 | DEMO | Greece | $561.5 mn | $155 mn |
| 769 | Newbridge Pharma | United Arab Emirates | $561 mn | $85 mn |
| 770 | Inibsa | Barcelona, Spain | $560.6 mn | $155 mn |
| 771 | Taloph | Henan Province, China | $559 mn | $193 mn |
| 772 | Famar | Greece | $557.3 mn | $154 mn |
| 773 | Akouos Therapeutics | Boston Area, US | $557.1 mn | $0 mn |
| 774 | TTY Biopharm | Taiwan | $555.9 mn | $144 mn |
| 775 | Amryt Pharma | Ireland | $554.4 mn | NA |
| 776 | Intersect ENT | Bay Area, US | $552.9 mn | $85 mn |
| 777 | HAL Allergy | Netherlands | $552.4 mn | $83 mn |
| 778 | Hansen Pharm | Hubei Province, China | $551.2 mn | $110 mn |
| 779 | Biosidus | Argentina | $551 mn | $54 mn |
| 780 | Northwest Bio | Bethesda MD, US | $548 mn | $2 mn |
| 781 | Farmfirma Soteks | Russia | $544.6 mn | $151 mn |
| 782 | Jianmin Group | Hubei Province, China | $542.5 mn | $304 mn |
| 783 | Cau Technology | Guangdong Province, China | $541.9 mn | $7.6 mn |
| 784 | WAVE Life Sciences | Boston Area, US | $541.1 mn | $12 mn |
| 785 | Elpen Pharma | Greece | $540 mn | $150 mn |
| 786 | Petrovax | Russia | $538.5 mn | $149 mn |
| 787 | Autolus Therapeutics | London, United Kingdom | $537.7 mn | $1.2 mn |
| 788 | Berlin Pharma | Thailand | $536.4 mn | $149 mn |
| 789 | Recursion Pharma | Salt City, Utah | $529 mn | NA |
| 790 | Saol Therapeutics | Atlanta, US | $528 mn | $80 mn |
| 791 | Sito Bio | Shandong Province, China | $527.8 mn | $124 mn |
| 792 | TaiGen | Taiwan | $526.2 mn | $0.7 mn |
| 793 | Taiwan Biotech | Taiwan | $525.4 mn | $145 mn |
| 794 | ImmunoGen | Boston Area, US | $525 mn | $86 mn |
| 795 | Kyowa Pharmaceutical | Osaka, Japan | $525 million | $230 mm |
| 796 | JGL | Croatia | $523.5 mn | $145 mn |
| 797 | Lepu Bio | Shanghai, China | $523 mn | NA |
| 798 | Honz Pharma | Guangdong Province, China | $521.8 mn | $127 mn |
| 799 | Getz Pharma | Pakistan | $520.2 mn | $144 mn |
| 800 | ANI Pharmaceuticals | Minnesota, US | $519.6 mn | $197 mn |
| 801 | PharmaResearch Prod. | South Korea | $519.4 mn | $76 mn |
| 802 | Yakult Pharma Segment | Tokyo, Japan | $519 mn | NA |
| 803 | Freeline Therapeutics | Stevenage, UK | $518.3 mn | $0 mn |
| 804 | Gossamer Bio | San Diego, US | $516.6 mn | NA |
| 805 | Shenqi Pharmaceutical | Guizhou, China | $516.2 mn | $262 mn |
| 806 | DHG Pharma | Can Tho, Vietnam | $516 mn | $164 mn |
| 807 | Valneva | Lyon, France | $515.7 mn | $134 mn |
| 808 | Ocular Therapeutix | Boston Area, US | $515.5 mn | $7.2 mn |
| 809 | Hua Medicine | Hong Kong | $513 mn | $3.1 mn |
| 810 | Enanta | Boston Area, US | $512.2 mn | $150 mn |
| 811 | Rana Pharm | South Korea | $511.2 mn | $142 mn |
| 812 | Cosar Pharmaceutical | Iran | $511.2 mn | $142 mn |
| 813 | Aerie Pharmaceuticals | North Carolina, US | $510.2 mn | $81 mn |
| 814 | Organogenesis | Boston Area, US | $508.1 mn | $269 mn |
| 815 | TherapeuticsMD | Boca Raton, FL | $506.2 mn | $62 mn |
| 816 | Consilient Health | Ireland | $506.2 mn | $76 mn |
| 817 | Huons | South Korea | $505.1 mn | $402 mn |
| 818 | SIGA Technologies | New York Area, US | $504.9 mn | $55 mn |
| 819 | Syndax Pharmaceuticals | Boston Area, US | $504.6 mn | $1.5 mn |
| 820 | Corium | Bay Area, US | $504 mn | NA |
| 821 | Genor Biopharma | Shanghai, China | $503 million | NA |
| 822 | IE Ulagay | Turkey | $501.4 mn | $139 mn |
| 823 | Ambiopharm | North August, SC, US | $500 mn | NA |
| 824 | Odin Pharmaceuticals | Somerset NJ | $500 mn | $80 mn |
| 825 | NKMax | Los Angeles, US | $496.5 mn | $7.6 mn |
| 826 | Teyi Pharmaceutical Group | Guangdong Province, China | $496 mn | $105 mn |
| 827 | Jeil | South Korea | $495.1 mn | $624 mn |
| 828 | TCR2 Therapeutics | Boston Area, US | $494.3 mn | NA |
| 829 | Celon Pharma | Poland | $494.2 mn | $25 mn |
| 830 | Hicin | Jiangsu Province, China | $493.8 mn | $119 mn |
| 831 | Fengyuan Pharmaceutical | Anhui Province, China | $493.3 mn | $459 mn |
| 832 | kaleo | Richmond, Virginia | $492.2 mn | $125 mn |
| 833 | Aprea Therapeutics, Inc. | Boston Area, US | $491.8 mn | NA |
| 834 | AMAG Pharma | Boston Area, US | $489.7 mn | $297 mn |
| 835 | Aprogen Pharmaceuticals | South Korea | $486.4 mn | $45 mn |
| 836 | Pandion Therapeutics | Boston Area, US | $484.9 mn | $4.9 mn |
| 837 | Green Cross Cell | South Korea | $483 mn | $31 mn |
| 838 | Arterium | Kiev, Ukraine | $482.7 mn | $134 mn |
| 839 | Sopharma | Bulgaria | $480.7 mn | $775 mn |
| 840 | OM Pharm | Zurich, Switzerland | $478 mn | $101 mn |
| 841 | ZIOPHARM Oncology | Boston Area, US | $476.2 mn | NA |
| 842 | ASKA Pharmaceutical | Tokyo, Japan | $474.7 mn | $484 mn |
| 843 | Dongwha Pharm | South Korea | $473.6 mn | $245 mn |
| 844 | Relmada Therapeutics | New York, NY | $471.4 mn | NA |
| 845 | YungShin Global | Taiwan | $470.4 mn | $280 mn |
| 846 | Vertice Pharma | New York Area, US | $468 mn | $130 mn |
| 847 | Farmac-Zabban | Bologna, Italy | $467.8 mn | $129 mn |
| 848 | MannKind | Los Angeles, US | $466 mn | $61 mn |
| 849 | Ansun Biopharma | San Diego, US | $466 million | NA |
| 850 | BiondVax Pharmaceuticals | Israel | $464.8 mn | NA |
| 851 | Amlyx | Boston Area, US | $464 million | NA |
| 852 | XOMA | Bay Area, US | $463.8 mn | $10 mn |
| 853 | Codupha | Ho Chi Minh, Vietnam | $463.6 mn | $128 mn |
| 854 | Yatai Pharma | Zhejiang Province, China | $463.4 mn | $55 mn |
| 855 | SERB | Belgium | $463.3 mn | $70 mn |
| 856 | FangSheng Pharma | Hubei Province, China | $462.8 mn | $160 mn |
| 857 | CMG Pharma | South Korea | $462.5 mn | $49 mn |
| 858 | Romark | Tampa, FL | $462 mn | $70 mn |
| 859 | Reig Jofre | Barcelona, Spain | $461.8 mn | $257 mn |
| 860 | Poly Pharmaceuticals | Huntsville, AL | $460.8 mn | $128 mn |
| 861 | Lianhuan Pharma | Jiangsu Province, China | $459.7 mn | $191 mn |
| 862 | Eagle Pharma | New York Area, US | $458.4 mn | $177 mn |
| 863 | Odonate Therapeutics | San Diego, US | $456.5 mn | NA |
| 864 | Qianjin Pharmaceutical | Hubei Province, China | $455.6 mn | $497 mn |
| 865 | Cue Biopharma | Boston Area, US | $454.7 mn | $4 mn |
| 866 | Longjin Pharmaceutical | Yunnan Province, China | $452.3 mn | $34 mn |
| 867 | ORIC Pharma | Bay Area, US | $451.9 mn | NA |
| 868 | Jiaying Pharmaceutical | Guangdong Province, China | $451.6 mn | $69 mn |
| 869 | Hanlim | South Korea | $448.5 mn | $124 mn |
| 870 | Daito Pharmaceutical | Toyama, Japan | $448.3 mn | $417 mn |
| 871 | Guangji Pharmaceutical | Hubei Province, China | $448.2 mn | $100 mn |
| 872 | Silence Therapeutics | London, United Kingdom | $447.1 mn | $1.7 mn |
| 873 | Bristol Laboratories | London, United Kingdom | $445.2 mn | $123 mn |
| 874 | Pengqi Technology Devp | Shanghai China | $443.1 mn | $121 mn |
| 875 | Soria Natural | Garray, Spain | $442.7 mn | $122 mn |
| 876 | MIP Group | Blieskastel, Germany | $442.4 mn | $122 mn |
| 877 | Osmotica | New York Area, US | $440.1 mn | $211 mn |
| 878 | SALVAT | Barcelona, Spain | $440 mn | $66 mn |
| 879 | Jacobson Pharma | Hong Kong | $439.4 mn | $202 mn |
| 880 | Indivior | Richmond, Virginia | $439.4 mn | $634 mn |
| 881 | Eutilex | South Korea | $439.1 mn | $0.8 mn |
| 882 | 89bio | Bay Area, US | $439.1 mn | NA |
| 883 | Aptose Biosciences | Toronto Area, Canada | $438.8 mn | NA |
| 884 | Pharma Foods International | Kyoto, Japan | $437.7 mn | $145 mn |
| 885 | Anika Therapeutics | Boston Area, US | $437 mn | $125 mn |
| 886 | Starpharma | Melbourne, Australia | $435.8 mn | $4.5 mn |
| 887 | Lisheng Pharma | Hebei Province, China | $435.1 mn | $194 mn |
| 888 | Taihe Health Technology | Sichuan Province, China | $433.3 mn | $101 mn |
| 889 | Farma de Colombia SAS | Colombia | $432 mn | $120 mn |
| 890 | Brainstorm Cell Tx | New York Area, US | $431.7 mn | NA |
| 891 | RedHill Biopharma | Tel-Aviv, Israel | $431.1 mn | $24 mn |
| 892 | Spectrum | Las Vegas, NV | $430.1 mn | NA |
| 893 | Anterogen | South Korea | $428.6 mn | $3.4 mn |
| 894 | Tricida | Bay Area, US | $428 mn | NA |
| 895 | Panlong Pharmaceutical | Shangluo, China | $426 mn | $64 mn |
| 896 | Alter Pharma | Belgium | $424.8 mn | $118 mn |
| 897 | Passage Bio, Inc. | Philadelphia Area, US | $423.4 mn | NA |
| 898 | Molecular Partners | Zurich, Switzerland | $422.3 mn | $15 mn |
| 899 | Caregen | South Korea | $422.2 mn | $53 mn |
| 900 | Ferndale Pharma Group | Michigan, US | $421.7 mn | $63 mn |
| 901 | Franco-Indian (FIPPL) | Mumbai, India | $420.7 mn | $116 mn |
| 902 | La borate Pharmaceuticals | Haryana, India | $420.1 mn | $116 mn |
| 903 | Qianjiang Pharmaceutical | Hubei Province, China | $418.5 mn | $111 mn |
| 904 | Highland Therapeutics | Toronto Area, Canada | $418 mn | NA |
| 905 | Molteni | Florence, Italy | $417.7 mn | $63 mn |
| 906 | TOA EIYO | Tokyo, Japan | $416 mn | $131 mn |
| 907 | Syros Pharma | Boston Area, US | $414.3 mn | $6.6 mn |
| 908 | Medigen | Taiwan | $413.1 mn | $18 mn |
| 909 | Beyond Spring Pharma | New York Area, US | $412.5 mn | NA |
| 910 | Theragen Etex | South Korea | $412.4 mn | $114 mn |
| 911 | Calliditas Therapeutics | Sweden | $412.2 mn | $5 mn |
| 912 | Vyera Therapeutics | New York Area, US | $411.8 mn | $62 mn |
| 913 | Neoleukin Therapeutics | Seattle, US | $411.6 mn | NA |
| 914 | Daewon Pharm | South Korea | $410.9 mn | $265 mn |
| 915 | HLS Therapeutics | Toronto Area, Canada | $409.8 mn | $53 mn |
| 916 | Puma Biotechnology | Los Angeles, US | $409.2 mn | $241 mn |
| 917 | Kymab | Cambridge, UK | $408.5 mn | NA |
| 918 | Seikagaku | Tokyo, Japan | $408.2 mn | $259 mn |
| 919 | Diachem | Bergamo, Italy | $408.2 mn | $113 mn |
| 920 | Adcock Ingram | South Africa | $407.5 mn | $423 mn |
| 921 | Applied Therapeutics, Inc. | New York Area, US | $404.7 mn | NA |
| 922 | Instituto Vital Brazil | Rio de Janeiro, Brazil | $403.3 mn | $112 mn |
| 923 | iNtRON Biotechnology | South Korea | $403.2 mn | $25 mn |
| 924 | Moehs | Barcelona, Spain | $401.8 mn | $111 mn |
| 925 | US WorldMeds | Louisville, KY, US | $400 mn | NA |
| 926 | Yisheng Pharma | Jilin Province, China | $398.9 mn | $128 mn |
| 927 | BioDelivery Sciences | North Carolina, US | $397.8 mn | $136 mn |
| 928 | Cosette Pharma | New York Area, US | $396 mn | $110 mn |
| 929 | Aft Pharm | New Zealand | $395.4 mn | $62 mn |
| 930 | Synmosa Biopharma | Taiwan | $393.9 mn | $97 mn |
| 931 | Ardelyx | Bay Area, US | $391.9 mn | $8.3 mn |
| 932 | Bluefish Pharmaceuticals | Stockholm, Sweden | $391.7 mn | $108 mn |
| 933 | Furui | Beijing, China | $390.6 mn | $114 mn |
| 934 | G1 Therapeutics | North Carolina, US | $390.4 mn | $2.1 mn |
| 935 | Blue Pharma-Industria | Portugal | $389.2 mn | $108 mn |
| 936 | Belupo | Croatia | $385.2 mn | $107 mn |
| 937 | Ohara Pharma | Tokyo, Japan | $384.3 mn | $183 mn |
| 938 | Mirum Pharmaceuticals | Bay Area, US | $384.2 mn | NA |
| 939 | Cellular Biomedicine | Bay Area, US | $382.3 mn | $0.2 mn |
| 940 | Sihuan Pharma | Beijing, China | $382.2 mn | $323 mn |
| 941 | Neutec Ilac | Turkey | $378.3 mn | $105 mn |
| 942 | Ildong Pharmaceutical | South Korea | $378 mn | $467 mn |
| 943 | AC Immune | Lausanne, Switzerland | $376.4 mn | $50 mn |
| 944 | Lee’s Pharmaceutical | Hong Kong | $376 mn | $150 mn |
| 945 | VIVUS | Bay Area, US | $375.5 mn | $56 mn |
| 946 | Scholar Rock Holding | Boston Area, US | $371.4 mn | $21 mn |
| 947 | Therabel Pharma | Netherlands | $370 mn | NA |
| 948 | Humanigen | Bay Area, US | $369.6 mn | NA |
| 949 | Fortress Biotech | New York Area, US | $369.5 mn | $43 mn |
| 950 | Savior Lifetec | Taiwan | $368.7 mn | $52 mn |
| 951 | Assembly Biosciences | Bay Area, US | $368.2 mn | $52 mn |
| 952 | Rigel Pharmaceuticals | Bay Area, US | $367.8 mn | $108 mn |
| 953 | Kala Pharmaceuticals | Boston Area, US | $367.7 mn | $4.5 mn |
| 954 | Materia Medica | Moscow, Russia | $367.2 mn | $102 mn |
| 955 | Fuji Pharma | Tokyo, Japan | $365.8 mn | $314 mn |
| 956 | Ovid Therapeutics | New York Area, US | $364.7 mn | NA |
| 957 | TransMedics Group | Andover, MA | $363.1 mn | $24 mn |
| 958 | Kintor Pharma | Jiangsu Province, China | $362.5 mn | $0 mn |
| 959 | Urovant Sciences | Irvine, CA | $362.3 mn | $0 mn |
| 960 | Darnitsa | Ukraine | $360 mn | $100 mn |
| 961 | MS Pharma – El Kendi | Algeria | $360 mn | $100 mn |
| 962 | Ascendis Health | South Africa | $359.3 mn | $427 mn |
| 963 | Kolon Life Sciences | South Korea | $358.9 mn | $128 mn |
| 964 | Nissin | Tendo, Japan | $358.1 mn | $171 mn |
| 965 | Indoco | Mumbai, India | $357.3 mn | $149 mn |
| 966 | Atreca | Bay Area, US | $357 mn | NA |
| 967 | Alium Group | Russia | $355.6 mn | $98 mn |
| 968 | The Searle Company | Pakistan | $355.3 mn | $98 mn |
| 969 | Kwang Dong Pharma | South Korea | $353.9 mn | $1 bn |
| 970 | Jinling Pharma | Jiangsu Province, China | $353.7 mn | $338 mn |
| 971 | Verona Pharma | London, United Kingdom | $351.5 mn | NA |
| 972 | EIPICO | Egypt | $351.5 mn | $192 mn |
| 973 | HNSP | Hainan Province, China | $350.6 mn | $40 mn |
| 974 | AVROBIO | Boston Area, US | $350.5 mn | NA |
| 975 | Checkmate Pharma | Boston Area, US | $350.4 mn | NA |
| 976 | Xinguan Pharmaceutical | Zhejiang Province, China | $350.2 mn | $39 mn |
| 977 | Flynn Pharma | London, United Kingdom | $349.9 mn | $59 mn |
| 978 | Tanvex | Taiwan | $349.2 mn | NA |
| 979 | C&Y Group | Shanxi Province, China | $347.7 mn | $137 mn |
| 980 | ACME Laboratories | Bangladesh | $347.5 mn | $213 mn |
| 981 | TAEJOON PHARM | South Korea | $347 mn | $96 mn |
| 982 | Farmabase | Jaguariuna, Brazil | $346.5 mn | $52 mn |
| 983 | Xbiotech | Austin, TX, US | $345.1 mn | $28 mn |
| 984 | Apex Healthcare | Malaysia | $343.6 mn | $167 mn |
| 985 | Oyster Point Pharma | Princeton, NJ, US | $342.2 mn | NA |
| 986 | Athersys, Inc. | Cleveland, Ohio | $341.7 mn | $0 mn |
| 987 | Paratek | Boston Area, US | $341.7 mn | $30 mn |
| 988 | PBF | Taiwan | $340.3 mn | $50 mn |
| 989 | Grupo Azevedos | Portugal | $339.8 mn | $94 mn |
| 990 | Centaur Pharma | Mumbai, India | $338.8 mn | $94 mn |
| 991 | SOTH EMA | Morocco | $338.4 mn | $178 mn |
| 992 | Orchard Therapeutics | London, United Kingdom | $338.4 mn | $3.1 mn |
| 993 | Cantargia | Lund, Sweden | $338.4 mn | NA |
| 994 | Tiansheng Pharma | Jiangsu Province, China | $337.8 mn | $199 mn |
| 995 | Tiziana Life Sciences | London, United Kingdom | $337.3 mn | NA |
| 996 | Aestura | South Korea | $336.9 mn | $93 mn |
| 997 | UroGen Pharma | New York Area, US | $336.5 mn | $0.3 mn |
| 998 | Telix | Melbourne, Australia | $336.4 mn | NA |
| 999 | China Chemical & Pharma | Taiwan | $336 mn | $272 mn |
| 1000 | Shapuaisi Pharma | Zhejiang Province, China | $335.5 mn | $55 mn |
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