Branded pharma sector includes companies whose drugs are patented and in the commercial stage. These companies comprise 69% (valuation of $3.6 trillion) of the value of the entire pharma industry and generated over $700 billion in revenue in 2019.
The most valuable companies in cardiometabolic care are Eli Lilly and Novo Nordisk. Biogen, UCB and Otsuka are leader in Cerntral Nervous System (CNS) disease care. Valuable companies in dermatology are Galderma, Pierre Fabre, LEO Pharma, Merz and Maruho. Pfizer, Merck and Roche are the clauable companies in oncology. Takeda and Vertex lead in rare disease segment.
See the full list of Top 1000 Pharmaceutical Companies below.
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- The Global Pharmaceutical Industry
- Rapid Growth of Biotech Sector
- The Evolving Branded Pharma Sector
- The Generic Pharma Sector
- Top 1000 Companies by Value
- Profiles of the Top 500 Companies
.
List of Top 1000 Pharmaceutical Companies by Value
.
Value | Name | Headquarters | Value Estimate | Revenue |
| Rank | Location | (Sep 2020) | (Trailing) | |
| 2020 | ||||
| 1 | Roche | Basel, Switzerland | $328 bn | $49 bn |
| 2 | Janssen (J&J) | Raritan, NJ, US | $279 bn | $42 bn |
| 3 | Pfizer | New York Area, US | $257 bn | $49 bn |
| 4 | AbbVie | Chicago Area | $242 bn | $36 bn |
| 5 | Merck | New York Area, US | $233 bn | $47 bn |
| 6 | Novartis | Basel, Switzerland | $210 bn | $49 bn |
| 7 | Amgen | Thousand Oaks, CA, US | $164 bn | $24 bn |
| 8 | AstraZeneca | Boston Area, US | $162 bn | $25 bn |
| 9 | Bristol-Myers Squibb | New York Area, US | $158 bn | $34 bn |
| 10 | Novo Nordisk | Copenhagen, Denmark | $155 bn | $19 bn |
| 11 | Eli Lilly | Indiana, US | $151 bn | $22 bn |
| 12 | Boehringer Ingelheim | Ingelheim, Germany | $148 bn | $22 bn |
| 13 | GlaxoSmithKline | London, United Kingdom | $136 bn | $43 bn |
| 14 | Bayer | Leverkusen, Germany | $133 bn | $20 bn |
| 15 | Sanofi | Paris, France | $120 bn | $42 bn |
| 16 | Takeda | Tokyo Japan | $104 bn | $30 bn |
| 17 | CSL | Parkville, Australia | $100 bn | $9 bn |
| 18 | Gilead | Bay Area, US | $87 bn | $22 bn |
| 19 | Zoetis | New York Area, US | $82 bn | $6.3 bn |
| 20 | Chugai | Tokyo, Japan | $72 bn | $6.8 bn |
| 21 | Hengrui Medicine | Jiangsu Province, China | $69 bn | $3.4 bn |
| 22 | Vertex Pharma | Boston Area, US | $65 bn | $5.4 bn |
| 23 | Regeneron | New York Area, US | $58 bn | $8.6 bn |
| 24 | Daiichi Sankyo | Tokyo, Japan | $54 bn | $8.9 bn |
| 25 | Merck KGaA Pharma | Berlin, Germany | $50 bn | $7.5 bn |
| 26 | Biogen | Boston Area, US | $48 bn | $14 bn |
| 27 | Yangtze River Pharma | Jiangsu Province, China | $44 bn | $12 bn |
| 28 | Servier | Paris, France | $36 bn | $5.4 bn |
| 29 | Teva | Israel | $35 bn | $16 bn |
| 30 | Celltrion | South Korea | $33 bn | $1.2 bn |
| 31 | CSPC Pharma | Hebei Province, China | $33 bn | $5 bn |
| 32 | Zhifei Bio | Sichuan Province, China | $31 bn | $1.7 bn |
| 33 | Seattle Genetics | Seattle, US | $30 bn | $1 bn |
| 34 | Menarini | Florence, Italy | $30 bn | $4.4 bn |
| 35 | Bausch Health | New York Area, US | $29 bn | $8.1 bn |
| 36 | Royalty Pharma | New York Area, US | $29 bn | $1.9 bn |
| 37 | Hansoh Pharma | Lianyungang, China | $26 bn | $1.1 bn |
| 38 | Astellas | Tokyo, Japan | $26 bn | $11 bn |
| 39 | Grifols | Barcelona, Spain | $26 bn | $6 bn |
| 40 | Alexion | New York Area, US | $25 bn | $5.5 bn |
| 41 | Eisai | Tokyo, Japan | $24 bn | $6.5 bn |
| 42 | Moderna | Boston Area, US | $24 bn | $105 mn |
| 43 | Qilu Pharma | Shandong Province, China | $24 bn | $3.6 bn |
| 44 | UCB | Brussels, Belgium | $24 bn | $5.8 bn |
| 45 | Sino Biopharma | Hong Kong | $23 bn | $3.4 bn |
| 46 | Changchun Tech | Jilin Province, China | $23 bn | $1.1 bn |
| 47 | Genmab | Copenhagen, Denmark | $22 bn | $1.5 bn |
| 48 | Otsuka | Tokyo, Japan | $22 bn | $13 bn |
| 49 | Pientzehuang Pharma | Fujian Province, China | $22 bn | $859 mn |
| 50 | Kelun Group | Sichuan Province, China | $22 bn | $6 bn |
| 51 | Galderma | La Tour-de-Peilz, Switzerland | $20 bn | $3 bn |
| 52 | BeiGene | Beijing, China | $20 bn | $224 mn |
| 53 | Mylan | Pittsburgh Area, US | $20 bn | $11 bn |
| 54 | Jemincare | Jianxi Province, China | $19.3 bn | $5.3 bn |
| 55 | Pierre Fabre | Paris, France | $18.7 bn | $2.8 bn |
| 56 | Immunomedics | New York Area, US | $18.6 bn | $20 mn |
| 57 | Incyte | Philadelphia Area, US | $18.5 bn | $2.3 bn |
| 58 | Horizon Therapeutics | Chicago Area | $17.9 bn | $1.5 bn |
| 59 | Yunnan Baiyao | Yunnan Province, China | $17.6 bn | $4.4 bn |
| 60 | Kangtai Bio | Guangdong Province, China | $17.3 bn | $283 mn |
| 61 | Octapharma | Lachen, Switzerland | $17.1 bn | $2.5 bn |
| 62 | Fosun Pharma | Shanghai, China | $16.7 bn | $4 bn |
| 63 | Ferring | Geneva, Switzerland | $16.7 bn | $2.5 bn |
| 64 | Sun Pharma | Mumbai, India | $16.4 bn | $4.2 bn |
| 65 | Abbott EPD | Chicago Area | $16.1 bn | $4.4 bn |
| 66 | Chiesi | Parma, Italy | $15.5 bn | $2.3 bn |
| 67 | BioNTech | Mainz, Germany | $15.4 bn | $141 mn |
| 68 | Ono | Osaka, Japan | $14.7 bn | $2.7 bn |
| 69 | BioMarin | Bay Area, US | $13.8 bn | $1.8 bn |
| 70 | Alnylam | Boston Area, US | $13.5 bn | $345 mn |
| 71 | Elanco | Indiana, US | $13.4 bn | $2.8 bn |
| 72 | Shionogi | Osaka, Japan | $13.3 bn | $3 bn |
| 73 | Mundipharma | New York Area, US | $13.2 bn | $2 bn |
| 74 | Hualan Bio | Henan Province, China | $13.1 bn | $521 mn |
| 75 | NC Pharma / EMS | Hortolandia, Brazil | $12.8 bn | $1.9 bn |
| 76 | Fresenius Kabi Segment | Hessen, Germany | $12.5 bn | $3.4 bn |
| 77 | Walvax | Yunnan Province, China | $12.5 bn | $169 mn |
| 78 | Samumed | San Diego, CA | $12.4 bn | NA |
| 79 | Kyowa Kirin | Tokyo, Japan | $12.2 bn | $2.8 bn |
| 80 | Recordati | Milan, Italy | $12.2 bn | $1.6 bn |
| 81 | Shanghai Pharma – Mfg | Shanghai, China | $12.1 bn | $3.3 bn |
| 82 | Tianjin Pharma | Tianjin, China | $12 bn | $3.3 bn |
| 83 | R-Pharm | Moscow, Russia | $11.9 bn | $1.8 bn |
| 84 | Grupo Insud | Madrid, Spain | $11.7 bn | $1.7 bn |
| 85 | Adimab | Lebanon, NH, US | $11.4 bn | NA |
| 86 | LEO Pharma | Copenhagen, Denmark | $11.4 bn | $1.7 bn |
| 87 | SK Biopharma | Seoul, Korea | $11 bn | $5.2 mn |
| 88 | Grunenthal | Aachen, Germany | $10.9 bn | $1.6 bn |
| 89 | Roemmers | Argentina | $10.8 bn | $3 bn |
| 90 | Innovent Biologics | Jiangsu Province, China | $10.5 bn | $238 mn |
| 91 | Vifor Pharma | St. Gallen, Switzerland | $10.2 bn | $2 bn |
| 92 | Bracco | Milan, Italy | $10.1 bn | $1.5 bn |
| 93 | Dr. Reddy’s | Hyderabad, India | $10.1 bn | $2.3 bn |
| 94 | Junshi Biosciences | Jiangsu Province, China | $10 bn | $147 mn |
| 95 | Ibsen | Paris, France | $10 bn | $3 bn |
| 96 | Roivant Sciences | New York Area, US | $10 bn | NA |
| 97 | Sarepta Therapeutics | Boston Area, US | $9.9 bn | $450 mn |
| 98 | Harbin Pharma | Heilongjiang Province, China | $9.7 bn | $2.7 bn |
| 99 | CureVac | Tubingen, Germany | $9.6 bn | $19 mn |
| 100 | Ceva Sante Animale | Dusseldorf, Germany | $9.3 bn | $1.4 bn |
| 101 | Neurocrine Biosciences | San Diego, US | $9.3 bn | $1 bn |
| 102 | Gan & Lee Pharma | Beijing, China | $9.3 bn | $445 mn |
| 103 | argenx | Netherlands | $8.8 bn | $70 mn |
| 104 | Humanwell Healthcare | Hubei Province, China | $8.8 bn | $2.9 bn |
| 105 | Sobi | Sweden | $8.7 bn | $1.6 bn |
| 106 | CR Pharma Rx Segment | Hong Kong | $8.6 bn | $4.3 bn |
| 107 | Hetero Drugs | Hyderabad, India | $8.6 bn | $2.3 bn |
| 108 | Merz | Hessen, Germany | $8.5 bn | $1.2 bn |
| 109 | Hikma | London, United Kingdom | $8.4 bn | $2.2 bn |
| 110 | Kangmei Pharma | Guangdong Province, China | $8.4 bn | $825 mn |
| 111 | Jazz Pharma | Bay Area, US | $8.4 bn | $2.2 bn |
| 112 | Huahai Pharma | Zhejiang Province, China | $8.4 bn | $855 mn |
| 113 | Cipla | Mumbai, India | $8.3 bn | $2.3 bn |
| 114 | Serum Institute of India | Pune, India | $8.3 bn | $819 mn |
| 115 | Baxter Pharma | Chicago Area | $8.2 bn | $2.2 bn |
| 116 | Shanghai RAAS | Shanghai, China | $8.2 bn | $367 mn |
| 117 | CanSino Biologics | Tianjin, China | $8.2 bn | $2.2 mn |
| 118 | Alfasigma | Florence, Italy | $8.2 bn | $1.2 bn |
| 119 | Mitsubishi Tanabe | Osaka, Japan | $8 bn | $3.8 bn |
| 120 | Lundbeck | Copenhagen, Denmark | $7.8 bn | $2.6 bn |
| 121 | Tiantan Biological | Beijing, China | $7.5 bn | $463 mn |
| 122 | Endo International | New York Area, US | $7.3 bn | $3 bn |
| 123 | Biocon | Bangalore, India | $7.3 bn | $871 mn |
| 124 | Torrent Pharma | Ahmedabad, India | $7.3 bn | $1 bn |
| 125 | Apotex | Toronto Area, Canada | $7.3 bn | $2 bn |
| 126 | STADA | Bad Vilbel, Germany | $7.2 bn | $3.1 bn |
| 127 | Ascendis Pharma | Copenhagen, Denmark | $7.1 bn | $9.4 mn |
| 128 | Santen | Osaka, Japan | $7.1 bn | $2.2 bn |
| 129 | Angelini | Rome, Italy | $7 bn | $1 bn |
| 130 | Schwabe | Stutensee, Germany | $7 bn | $1 bn |
| 131 | Aurobindo | Hyderabad, India | $6.9 bn | $3.1 bn |
| 132 | Betta Pharm | Zhejiang Province, China | $6.8 bn | $246 mn |
| 133 | Intas Pharma | Ahmedabad, India | $6.6 bn | $1.8 bn |
| 134 | Exelixis | Bay Area, US | $6.6 bn | $998 mn |
| 135 | Ache Laboratorios | Guarulhos, Brazil | $6.6 bn | $1 bn |
| 136 | Unilab | Philippines | $6.6 bn | $1 bn |
| 137 | Dainippon Sumitomo | Osaka, Japan | $6.6 bn | $4.6 bn |
| 138 | Orion | Finland | $6.5 bn | $1.2 bn |
| 139 | Lupin | Mumbai, India | $6.4 bn | $1.9 bn |
| 140 | Huadong Medicine | Zhejiang Province, China | $6.4 bn | $4.7 bn |
| 141 | Mirati Therapeutics | San Diego, US | $6.4 bn | $1.7 mn |
| 142 | Zydus Cadila | Ahmedabad, India | $6.3 bn | $1.9 bn |
| 143 | Kedrion | Florence, Italy | $6.3 bn | $953 mn |
| 144 | King-Friend Bio | Jiangsu Province, China | $6.2 bn | $380 mn |
| 145 | Shin Poong | South Korea | $6.2 bn | $164 mn |
| 146 | lonis | San Diego, US | $6.1 bn | $940 mn |
| 147 | Emergent BioSolutions | Gaithersburg, MD, US | $6 bn | $1.2 bn |
| 148 | Green Valley Pharma | Shanghai, China | $5.9 bn | $900 mn |
| 149 | Guangzhou Pharma | Guangdong Province, China | $5.9 bn | $8.7 bn |
| 150 | MyoKardia | Bay Area, US | $5.9 bn | NA |
| 151 | Momenta | Boston Area, US | $5.8 bn | $30 mn |
| 152 | Kanghong Pharma | Sichuan Province, China | $5.8 bn | $443 mn |
| 153 | Acceleron | Boston Area, US | $5.7 bn | $87 mn |
| 154 | Novavax | Gaithersburg, MD, US | $5.7 bn | $50 mn |
| 155 | Aspen Pharmacare | South Africa | $5.7 bn | $2.2 bn |
| 156 | Italfarmaco | Milan, Italy | $5.7 bn | $856 mn |
| 157 | Zambon | Milan, Italy | $5.6 bn | $853 mn |
| 158 | Maruho | Osaka, Japan | $5.6 bn | $847 mn |
| 159 | ACADIA Pharma | San Diego, US | $5.5 bn | $393 mn |
| 160 | Zai Lab | Shanghai China | $5.5 bn | $28 mn |
| 161 | Youcare Pharma | Beijing, China | $5.4 bn | $1.5 bn |
| 162 | Salubris Pharma | Guangdong Province, China | $5.4 bn | $516 mn |
| 163 | Nippon Shinyaku | Tokyo, Japan | $5.2 bn | $1.1 bn |
| 164 | Grupo Ferrer | Barcelona, Spain | $5.2 bn | $790 mn |
| 165 | Yifan Pharma | Zhejiang Province, China | $5.1 bn | $775 mn |
| 166 | CRISPR Therapeutics | Zug, Switzerland | $5.1 bn | $289 mn |
| 167 | PeptiDream | Kawasaki, Japan | $5.1 bn | $0 mn |
| 168 | Livzon | Guangdong Province, China | $5 bn | $1.3 bn |
| 169 | ALTEOGEN | South Korea | $5 bn | $36 mn |
| 170 | Tasly Pharma | Tianjin, China | $5 bn | $2.5 bn |
| 171 | Alkem | Mumbai, India | $4.8 bn | $1.1 bn |
| 172 | Kalbe | North Sumatra, Indonesia | $4.8 bn | $1.5 bn |
| 173 | Dechra Pharma | Northern UK | $4.7 bn | $637 mn |
| 174 | Mallinckrodt | London, United Kingdom | $4.5 bn | $2.3 bn |
| 175 | Chi-Med | Hong Kong | $4.5 bn | $209 mn |
| 176 | Laboratoires Thea | Clermont-Ferrand, France | $4.5 bn | $678 mn |
| 177 | lovance | Bay Area, US | $4.5 bn | NA |
| 178 | Samsung Bioepis | South Korea | $4.4 bn | $850 mn |
| 179 | Wolwo Pharma | Zhejiang Province, China | $4.4 bn | $88 mn |
| 180 | Dongbao Pharma | Jilin Province, China | $4.4 bn | $398 mn |
| 181 | Buchang Pharma | Shandong Province, China | $4.4 bn | $2.1 bn |
| 182 | Mega Pharma | Uruguay | $4.3 bn | $1.2 bn |
| 183 | Kanghua Biological | Sichuan Province, China | $4.3 bn | $104 mn |
| 184 | Yiling Pharma | Hebei Province, China | $4.3 bn | $1 bn |
| 185 | NCPC | Hebei Province, China | $4.3 bn | $1.5 bn |
| 186 | Abdi Ibrahim | Turkey | $4.2 bn | $639 mn |
| 187 | Jinyu Bio-Tech | Mongolia | $4.2 bn | $175 mn |
| 188 | CHEPLAPHARM | Pomerania, Germany | $4.2 bn | $1.1 bn |
| 189 | Ultragenyx | Bay Area, US | $4.2 bn | $159 mn |
| 190 | Allogene | Bay Area, US | $4.1 bn | NA |
| 191 | Meiji Pharma Business | Tokyo, Japan | $4.1 bn | $1.9 bn |
| 192 | Orifarm | Copenhagen, Denmark | $4 bn | $1.1 bn |
| 193 | Pharmstandard | Dolgoprudny, Russia | $4 bn | $1.1 bn |
| 194 | Grupo Bago | Argentina | $4 bn | $1.1 bn |
| 195 | Apeloa Pharma | Zhejiang Province, China | $4 bn | $1 bn |
| 196 | Polpharma | Poland | $3.9 bn | $1 bn |
| 197 | Idorsia | Basel, Switzerland | $3.9 bn | $72 mn |
| 198 | Oneness Biotech | Taiwan | $3.9 bn | $1.4 mn |
| 199 | Hisun Pharma | Zhejiang Province, China | $3.8 bn | $1.5 bn |
| 200 | Halozyme | San Diego, US | $3.8 bn | $180 mn |
| 201 | IBSA | Lugano, Switzerland | $3.8 bn | $572 mn |
| 202 | Celltrion Pharm | South Korea | $3.7 bn | $152 mn |
| 203 | neuraxpharm | Langenfeld, Germany | $3.7 bn | $566 mn |
| 204 | Hypera | Sao Paolo, Brazil | $3.7 bn | $694 mn |
| 205 | Ipca | Mumbai, India | $3.7 bn | $617 mn |
| 206 | Esteve | Barcelona, Spain | $3.7 bn | $556 mn |
| 207 | Biohaven | New York Area, US | $3.7 bn | $10 mn |
| 208 | Haisco | Sichuan Province, China | $3.7 bn | $498 mn |
| 209 | Gedeon Richter | Hungary | $3.6 bn | $1.7 bn |
| 210 | Relay Therapeutics | Boston Area, US | $3.6 bn | $0 mn |
| 211 | Legend Biotech | Jiangsu Province, China | $3.6 bn | $61 mn |
| 212 | Hanmi Pharm | South Korea | $3.6 bn | $917 mn |
| 213 | Barakat Pharmaceutical | Iran | $3.6 bn | $1 bn |
| 214 | Blueprint Medicines | Boston Area, US | $3.6 bn | $75 mn |
| 215 | Allakos | Bay Area, US | $3.6 bn | NA |
| 216 | ALK | Copenhagen, Denmark | $3.6 bn | $505 mn |
| 217 | LG Life Sciences | South Korea | $3.6 bn | $540 mn |
| 218 | JCR | Ashiya, Japan | $3.5 bn | $230 mn |
| 219 | Eurofarma | Sao Paolo, Brazil | $3.5 bn | $982 mn |
| 220 | Genexine | South Korea | $3.5 bn | $4.1 mn |
| 221 | ROHTO | Osaka, Japan | $3.5 bn | $1.7 bn |
| 222 | Besins | Monaco | $3.5 bn | $531 mn |
| 223 | Amicus Therapeutics | New York Area, US | $3.5 bn | $226 mn |
| 224 | Perrigo Rx Business | Allegan, MI, US | $3.5 bn | $968 mn |
| 225 | Denali Therapeutics | Bay Area, US | $3.5 bn | $27 mn |
| 226 | Kyoritsu Seiyaku | Tokyo, Japan | $3.5 bn | $524 mn |
| 227 | Zentiva | Czech Republic | $3.4 bn | $957 mn |
| 228 | Genus | London, United Kingdom | $3.4 bn | $682 mn |
| 229 | Amneal | New York Area, US | $3.4 bn | $1.7 bn |
| 230 | China Grand Pharma | Hong Kong | $3.4 bn | $807 mn |
| 231 | FibroGen | Bay Area, US | $3.4 bn | $108 mn |
| 232 | Vir Biotechnology | Bay Area, US | $3.4 bn | $75 mn |
| 233 | Dermapharm | Munich Area, Germany | $3.4 bn | $855 mn |
| 234 | Schrodinger | Bangalore, India | $3.4 bn | $95 mn |
| 235 | Dompe | Milan, Italy | $3.3 bn | $507 mn |
| 236 | Luoxin Pharma | Shandong Province, China | $3.3 bn | $897 mn |
| 237 | MorphoSys | Munich Area, Germany | $3.3 bn | $329 mn |
| 238 | Shafadarou Investment | Iran | $3.3 bn | $906 mn |
| 239 | Norgine | Netherlands | $3.3 bn | $494 mn |
| 240 | AnkeBio | Anhui Province, China | $3.3 bn | $235 mn |
| 241 | Yuhan | South Korea | $3.2 bn | $1.2 bn |
| 242 | Macleods Pharma | Mumbai, India | $3.2 bn | $891 mn |
| 243 | PROBIOMED | Mexico | $3.2 bn | $317 mn |
| 244 | Dr. Falk Pharma | Freiburg im Breisgau, Germany | $3.2 bn | $485 mn |
| 245 | ChemoCentryx | Bay Area, US | $3.2 bn | $76 mn |
| 246 | Arrowhead Pharma | Los Angeles, US | $3.2 bn | $123 mn |
| 247 | Taisho Pharma | Tokyo, Japan | $3.2 bn | $2.8 bn |
| 248 | Pars Darou | Iran | $3.2 bn | $881 mn |
| 249 | China Meheco Group | Beijing, China | $3.2 bn | $5.2 bn |
| 250 | China Biologic Products | Beijing, China | $3.1 bn | $511 mn |
| 251 | Bridgebio Pharma | Bay Area, US | $3.1 bn | $40 mn |
| 252 | LFB | Paris, France | $3.1 bn | $472 mn |
| 253 | PTC Therapeutics | New York Area, US | $3.1 bn | $311 mn |
| 254 | Immunovant | New York Area, US | $3.1 bn | NA |
| 255 | lnsmed | New York Area, US | $3.1 bn | $163 mn |
| 256 | Asahi Kasei Pharma | Tokyo, Japan | $3.1 bn | NA |
| 257 | GC Pharma | South Korea | $3 bn | $1.1 bn |
| 258 | BrightGene Bio | Jiangsu Province, China | $3 bn | $84 mn |
| 259 | medac gmbh | Wedel, Germany | $2.9 bn | $446 mn |
| 260 | 3SBio | Liaoning Province, China | $2.9 bn | $760 mn |
| 261 | Amoytop Biotech | Fujian Province, China | $2.9 bn | $109 mn |
| 262 | United Therapeutics | Silver Spring MD, US | $2.9 bn | $1.4 bn |
| 263 | GBT | Bay Area, US | $2.9 bn | $47 mn |
| 264 | GW Pharmaceuticals | Cambridge, UK | $2.9 bn | $441 mn |
| 265 | Arena Pharma | San Diego, US | $2.9 bn | $4.6 mn |
| 266 | Alvogen | New York Area, US | $2.9 bn | $800 mn |
| 267 | Prasco | Mason, Ohio, US | $2.9 bn | $800 mn |
| 268 | Simcere Pharma | Jiangsu Province, China | $2.9 bn | $800 mn |
| 269 | ADC Therapeutics | Geneva, Switzerland | $2.9 bn | $0 mn |
| 270 | Axsome | New York, NY | $2.9 bn | NA |
| 271 | BIOCAD | St. Petersburg, Russia | $2.9 bn | $283 mn |
| 272 | Guojian Pharma | Shanghai, China | $2.8 bn | $149 mn |
| 273 | KrKa | Slovenia | $2.8 bn | $1.7 bn |
| 274 | Chipscreen | Guangdong Province, China | $2.8 bn | $28 mn |
| 275 | Harmony Biosciences | Philadelphia Area, US | $2.8 bn | $63 mn |
| 276 | Fate Therapeutics | San Diego, US | $2.8 bn | $13 mn |
| 277 | Reata Pharma | Irving, TX, US | $2.8 bn | $13 mn |
| 278 | Hisamitsu | Tosu, Japan | $2.8 bn | $1.2 bn |
| 279 | China Medical System | Guangdong Province, China | $2.8 bn | $880 mn |
| 280 | Biolab Sanus Pharma | Sao Paolo, Brazil | $2.8 bn | $418 mn |
| 281 | Biolab Sanus Pharma | Sao Paolo, Brazil | $2.8 bn | $418 mn |
| 282 | Mankind Pharma | Delhi, India | $2.8 bn | $766 mn |
| 283 | Sawai | Osaka, Japan | $2.7 bn | $1.6 bn |
| 284 | Jubilant Pharma Segment | Noida, UP, India | $2.7 bn | $758 mn |
| 285 | TG Therapeutics | New York Area, US | $2.7 bn | $0.1 mn |
| 286 | Ethypharm | Paris, France | $2.7 bn | $413 mn |
| 287 | China TCM Holdings | Hong Kong | $2.7 bn | $1.9 bn |
| 288 | Kowa Pharma Segment | Tokyo, Japan | $2.7 bn | $1.3 bn |
| 289 | Alembic | Ahmedabad, India | $2.7 bn | $661 mn |
| 290 | Alkermes | Boston Area, US | $2.7 bn | $1.1 bn |
| 291 | Nektar | Bay Area, US | $2.7 bn | $162 mn |
| 292 | Neopharm Ltd | Israel | $2.6 bn | $400 mn |
| 293 | AoDong Medicine | Jilin Province, China | $2.6 bn | $363 mn |
| 294 | Chase Sun Pharma | Tianjin, China | $2.6 bn | $778 mn |
| 295 | Akeso | Guangdong Province, China | $2.6 bn | $10 mn |
| 296 | Joincare Pharma | Guangdong Province, China | $2.6 bn | $1.7 bn |
| 297 | Turning Point | San Diego, US | $2.6 bn | NA |
| 298 | Pacira | New York Area, US | $2.6 bn | $408 mn |
| 299 | Dendreon / Sanpower | Los Angeles, US | $2.6 bn | $393 mn |
| 300 | Bio-Thera Solutions | Guangdong Province, China | $2.6 bn | $7 mn |
| 301 | Zelgen Bio | Anhui Province, China | $2.6 bn | NA |
| 302 | Jumpcan Pharma | Jiangsu Province, China | $2.6 bn | $847 mn |
| 303 | Luye Pharma | Shandong Province, China | $2.5 bn | $876 mn |
| 304 | Shuanglin Biopharma | Guangdong Province, China | $2.5 bn | $133 mn |
| 305 | Pharmascience | Quebec, Canada | $2.5 bn | $700 mn |
| 306 | Almirall | Barcelona, Spain | $2.5 bn | $981 mn |
| 307 | Karo Pharma | Sweden | $2.5 bn | $276 mn |
| 308 | Ocumension | Jiangsu Province, China | $2.5 bn | $0.3 mn |
| 309 | Fudan-Zhangjiang | Shanghai China | $2.5 bn | $123 mn |
| 310 | Emcure | Mumbai, India | $2.4 bn | $673 mn |
| 311 | OPKO Health | Miami, Florida, US | $2.4 bn | $965 mn |
| 312 | Seres Therapeutics | Boston Area, US | $2.4 bn | $28 mn |
| 313 | Xianju Pharma | Zhejiang Province, China | $2.4 bn | $512 mn |
| 314 | Tsumura | Osaka, Japan | $2.4 bn | $1.1 bn |
| 315 | Boya Bio | Jiangxi Province, China | $2.4 bn | $404 mn |
| 316 | Galapagos | Belgium | $2.4 bn | $1.1 bn |
| 317 | Teijin Pharma | Tokyo, Japan | $2.3 bn | $1.1 bn |
| 318 | Fidia Farma | Abano Terme, Italy | $2.3 bn | $354 mn |
| 319 | Glenmark | Mumbai, India | $2.3 bn | $1.4 bn |
| 320 | CytoDyn | Seattle, US | $2.3 bn | NA |
| 321 | Sage Therapeutics | Boston Area, US | $2.3 bn | $8.9 mn |
| 322 | Biocodex | Paris, France | $2.3 bn | $350 mn |
| 323 | Helsinn | Lugano, Switzerland | $2.3 bn | $350 mn |
| 324 | Deciphera | Boston Area, US | $2.3 bn | $7.1 mn |
| 325 | Virbac | Carros, France | $2.3 bn | $1 bn |
| 326 | Conba Pharma | Zhejiang Province, China | $2.3 bn | $893 mn |
| 327 | BIAL | Portugal | $2.3 bn | $345 mn |
| 328 | Zhejiang Medicine | Zhejiang Province, China | $2.3 bn | $989 mn |
| 329 | Adamed | Poland | $2.3 bn | $343 mn |
| 330 | ASK Pharm | Jiangsu Province, China | $2.2 bn | $526 mn |
| 331 | Hile Bio-Technology | Shanghai, China | $2.2 bn | $36 mn |
| 332 | China Animal Husbandry | Beijing, China | $2.2 bn | $644 mn |
| 333 | bluebird bio | Boston Area, US | $2.2 bn | $239 mn |
| 334 | Liomont | Mexico | $2.2 bn | $600 mn |
| 335 | Stallergenes Greer | London, United Kingdom | $2.2 bn | $326 mn |
| 336 | Haiyao | Hainan Province, China | $2.1 bn | $298 mn |
| 337 | Bailing Group Pharma | Guizhou, China | $2.1 bn | $393 mn |
| 338 | Aristo Pharma | Berlin, Germany | $2.1 bn | $590 mn |
| 339 | Nhwa Pharma | Jiangsu Province, China | $2.1 bn | $500 mn |
| 340 | Huvepharma | Bulgaria | $2.1 bn | $320 mn |
| 341 | PharmaMar | Madrid, Spain | $2.1 bn | $240 mn |
| 342 | Aimmune Therapeutics | Bay Area, US | $2.1 bn | $0.5 mn |
| 343 | Xinbang Pharma | Guizhou, China | $2.1 bn | $860 mn |
| 344 | Haohai Biotech | Shanghai, China | $2.1 bn | NA |
| 345 | Myovant Sciences | Bay Area, US | $2 bn | $33 mn |
| 346 | ROVI | Madrid, Spain | $2 bn | $444 mn |
| 347 | SSY Group | Hong Kong | $2 bn | $528 mn |
| 348 | Norbrook Laboratories | Northern Ireland, UK | $2 bn | $305 mn |
| 349 | Intra-Cellular Therapies | New York Area, US | $2 bn | $3 mn |
| 350 | lnovio Pharma | Philadelphia Area, US | $2 bn | $2.7 mn |
| 351 | Mesoblast | Melbourne, Australia | $2 bn | $32 mn |
| 352 | Micro Labs | Bangalore, India | $2 bn | $558 mn |
| 353 | Cheezheng Tibetan Med | Nyingchi, Tibet, China | $2 bn | $198 mn |
| 354 | Agios | Boston Area, US | $2 bn | $185 mn |
| 355 | Kodiak Sciences | Palo Alto, CA | $1.9 bn | NA |
| 356 | Taiji Group | Sichuan Province, China | $1.9 bn | $1.5 bn |
| 357 | Revance | Bay Area, US | $1.9 bn | $0.4 mn |
| 358 | Apellis Pharma | Boston Area, US | $1.9 bn | NA |
| 359 | Natco | Hyderabad, India | $1.9 bn | $262 mn |
| 360 | MSN Laboratories | Hyderabad, India | $1.9 bn | $520 mn |
| 361 | Karuna Therapeutics | Boston Area, US | $1.9 bn | NA |
| 362 | Sorrento Therapeutics | San Diego, US | $1.9 bn | $35 mn |
| 363 | IGM Biosciences | Bay Area, US | $1.9 bn | NA |
| 364 | Shyndec | Shanghai, China | $1.8 bn | $1.7 bn |
| 365 | CK Life Sciences | Hong Kong | $1.8 bn | $612 mn |
| 366 | Bukwang Pharma | South Korea | $1.8 bn | $142 mn |
| 367 | Ironwood Pharma | Boston Area, US | $1.8 bn | $426 mn |
| 368 | Advanz Pharma | London, United Kingdom | $1.8 bn | $503 mn |
| 369 | Medochemie | Cyprus | $1.8 bn | $500 mn |
| 370 | Brilliant Pharma | Sichuan Province, China | $1.8 bn | $500 mn |
| 371 | Grupo Uriach | Barcelona, Spain | $1.8 bn | $271 mn |
| 372 | Square Pharma | Bangladesh | $1.8 bn | $545 mn |
| 373 | Acino | Zurich, Switzerland | $1.8 bn | $495 mn |
| 374 | Zhongheng Group | Guangxi Province, China | $1.8 bn | $530 mn |
| 375 | Ajanta Pharma | Mumbai, India | $1.8 bn | $350 mn |
| 376 | Xencor | Los Angeles, US | $1.8 bn | $70 mn |
| 377 | SL Pharm | Hainan Province, China | $1.7 bn | $214 mn |
| 378 | Hisoar Pharma | Zhejiang Province, China | $1.7 bn | $356 mn |
| 379 | Xiangxue Pharma | Guangdong Province, China | $1.7 bn | $464 mn |
| 380 | Eidos Therapeutics | Bay Area, US | $1.7 bn | $26 mn |
| 381 | ZBD Pharmaceutical | Heilongjiang Province, China | $1.7 bn | $450 mn |
| 382 | IDT Biologika | Dessau-Roillau, Germany | $1.7 bn | $259 mn |
| 383 | Siam Bioscience | Thailand | $1.7 bn | $169 mn |
| 384 | JT Pharma / Torii | Tokyo, Japan | $1.7 bn | $815 mn |
| 385 | Theramex | London, United Kingdom | $1.7 bn | $258 mn |
| 386 | HIPRA | Spain, Other | $1.7 bn | $256 mn |
| 387 | Zhongsheng Pharma | Guangdong Province, China | $1.7 bn | $284 mn |
| 388 | Quantum Hi-Tech | Guangdong Province, China | $1.7 bn | $195 mn |
| 389 | Biotest / Creat Group | Berlin, Germany | $1.7 bn | $516 mn |
| 390 | Sebela Pharma | Atlanta, US | $1.7 bn | $250 mn |
| 391 | Tecnoquimicas | Colombia | $1.6 bn | $458 mn |
| 392 | Corcept Therapeutics | Bay Area, US | $1.6 bn | $351 mn |
| 393 | SINQI | Liaoning Province, China | $1.6 bn | $74 mn |
| 394 | Towa Pharma | Osaka, Japan | $1.6 bn | $1.1 bn |
| 395 | Nichi-Iko | Toyama, Japan | $1.6 bn | $1.7 bn |
| 396 | Kolmar Medicine Unit | South Korea | $1.6 bn | $567 mn |
| 397 | Hugel | South Korea | $1.6 bn | $162 mn |
| 398 | Alphamab Oncology | Jiangsu Province, China | $1.6 bn | $1.4 mn |
| 399 | Aurinia Pharma | Vancouver, Canada | $1.6 bn | $0.3 mn |
| 400 | AnGes | Osaka, Japan | $1.6 bn | $1.5 mn |
| 401 | USV | Mumbai, India | $1.6 bn | $446 mn |
| 402 | Arkopharma | Lyon, France | $1.6 bn | $241 mn |
| 403 | Kimia Farma | Sumatera Utara, Indonesia | $1.6 bn | $662 mn |
| 404 | Bavarian Nordic | Copenhagen, Denmark | $1.6 bn | $226 mn |
| 405 | Dezhan Healthcare | Beijing, China | $1.6 bn | $221 mn |
| 406 | SpringWorks | New York Area, US | $1.6 bn | NA |
| 407 | Zixin Pharma | Jilin Province, China | $1.6 bn | $65 mn |
| 408 | HanAll Biopharma | South Korea | $1.6 bn | $82 mn |
| 409 | Cytokinetics | Bay Area, US | $1.6 bn | $18 mn |
| 410 | Gebro Pharma | Austria | $1.6 bn | $236 mn |
| 411 | Clinigen | Northern UK | $1.5 bn | $624 mn |
| 412 | Revolution Medicines | Bay Area, US | $1.5 bn | $46 mn |
| 413 | Isdin | Barcelona, Spain | $1.5 bn | $232 mn |
| 414 | Laboratorio Elea | Argentina | $1.5 bn | $232 mn |
| 415 | ALX Oncology | Bay Area, US | $1.5 bn | $3.6 mn |
| 416 | Forma Therapeutics | Boston Area, US | $1.5 bn | $10 mn |
| 417 | FujiFilm Pharma | Tokyo, Japan | $1.5 bn | NA |
| 418 | Laboratorios Sanfer | Mexico | $1.5 bn | NA |
| 419 | Sanovel | Turkey | $1.5 bn | $227 mn |
| 420 | SPIMACO | Mosadia, Saudi Arabia | $1.5 bn | $417 mn |
| 421 | Abiogen Pharma | Pisa, Italy | $1.5 bn | $223 mn |
| 422 | Akcea Therapeutics | Boston Area, US | $1.5 bn | $336 mn |
| 423 | uniQure | Netherlands | $1.5 bn | $5.3 mn |
| 424 | Innocare | Hong Kong | $1.5 bn | $0.1 mn |
| 425 | Microgen | Moscow, Russia | $1.5 bn | $144 mn |
| 426 | Intercept Pharma | New York Area, US | $1.5 bn | $283 mn |
| 427 | Zymeworks | Vancouver, Canada | $1.4 bn | $30 mn |
| 428 | Sobhan Pharma | Iran | $1.4 bn | $397 mn |
| 429 | Viela Bio | Gaithersburg, MD, US | $1.4 bn | $30 mn |
| 430 | Bimeda Animal Health | Ireland | $1.4 bn | $216 mn |
| 431 | Y-mAbs Therapeutics | New York Area, US | $1.4 bn | NA |
| 432 | Northeast Pharma | Shenyang Province, China | $1.4 bn | $1.1 bn |
| 433 | Sunflower Pharma | Heilongjiang Province, China | $1.4 bn | $507 mn |
| 434 | Biological E. | Hyderabad, India | $1.4 bn | $140 mn |
| 435 | Editas Medicine | Boston Area, US | $1.4 bn | $32 mn |
| 436 | Cortexyme | Bay Area, US | $1.4 bn | NA |
| 437 | Yungjin Pharm | South Korea | $1.4 bn | $147 mn |
| 438 | Kymera | Boston Area, US | $1.4 bn | NA |
| 439 | Lukang Pharma | Shandong Province, China | $1.4 bn | $549 mn |
| 440 | AlloVir | Boston Area, US | $1.4 bn | $0 mn |
| 441 | Hybio Pharma | Guangdong Province, China | $1.4 bn | $85 mn |
| 442 | URSAPHARM | Saarbrucken, Germany | $1.4 bn | $206 mn |
| 443 | Uniao Qufmica | Sao Paolo, Brazil | $1.4 bn | $376 mn |
| 444 | HEC Pharma | Guangdong Province, China | $1.4 bn | $741 mn |
| 445 | Zhongxin Pharma | Tianjin, China | $1.3 bn | $955 mn |
| 446 | MacroGenics | Rockville MD, US | $1.3 bn | $77 mn |
| 447 | Kern Pharma | Barcelona, Spain | $1.3 bn | $368 mn |
| 448 | Medison | Israel | $1.3 bn | $200 mn |
| 449 | Theravance Biopharma | Bay Area, US | $1.3 bn | $76 mn |
| 450 | Cosmo Pharma | Lugano, Switzerland | $1.3 bn | $75 mn |
| 451 | Nestle Pharma Ops | Vevey, Switzerland | $1.3 bn | $288 mn |
| 452 | Cerevel Therapeutics | Boston Area, US | $1.3 bn | NA |
| 453 | Atnahs | London, United Kingdom | $1.3 bn | $360 mn |
| 454 | Compugen | Israel | $1.3 bn | NA |
| 455 | Coherus | Bay Area, US | $1.3 bn | $487 mn |
| 456 | Mersana | Boston Area, US | $1.3 bn | $1.6 mn |
| 457 | II-Yang Pharm. | South Korea | $1.3 bn | $270 mn |
| 458 | Kura Oncology | San Diego, US | $1.3 bn | NA |
| 459 | Madrigal Pharma | Philadelphia Area, US | $1.3 bn | NA |
| 460 | GNI Group | Tokyo, Japan | $1.3 bn | $77 mn |
| 461 | KUP | South Korea | $1.2 bn | $136 mn |
| 462 | Weiguang Biological | Guangdong Province, China | $1.2 bn | $122 mn |
| 463 | Changshan Bio | Hebei Province, China | $1.2 bn | $308 mn |
| 464 | Nordic Pharma | Paris, France | $1.2 bn | $182 mn |
| 465 | Ringpu BioTech | Hebei Province, China | $1.2 bn | $245 mn |
| 466 | Renata | Bangladesh | $1.2 bn | $310 mn |
| 467 | Gloria Pharmaceuticals | Heilongjiang Province, China | $1.2 bn | $527 mn |
| 468 | Zealand Pharma | Copenhagen, Denmark | $1.2 bn | $38 mn |
| 469 | Medy-Tox | South Korea | $1.2 bn | $151 mn |
| 470 | Beam Therapeutics | Boston Area, US | $1.2 bn | NA mn |
| 471 | Ligand | San Diego, US | $1.2 bn | $126 mn |
| 472 | Leadiant Biosciences | Rome, Italy | $1.2 bn | $180 mn |
| 473 | Zhenghai Biotech | Shandong Province, China | $1.2 bn | $39 mn |
| 474 | Reliance Life Sciences | Mumbai, India | $1.2 bn | $116 mn |
| 475 | Nkarta | Bay Area, US | $1.2 bn | $0 mn |
| 476 | GuangYuYuang | Shaanxi Province, China | $1.2 bn | $156 mn |
| 477 | Mayinglong Pharma | Hubei Province, China | $1.2 bn | $341 mn |
| 478 | Zeria Pharma | Tokyo, Japan | $1.2 bn | $543 mn |
| 479 | Laboratoire Aguettant | Lyon, France | $1.2 bn | $177 mn |
| 480 | Adaptimmune | Oxford, UK | $1.2 bn | $2.2 mn |
| 481 | Duchesnay | Quebec, Canada | $1.2 bn | $175 mn |
| 482 | Mezzion | South Korea | $1.2 bn | $17 mn |
| 483 | Rocket Pharma | New York Area, US | $1.2 bn | NA |
| 484 | Akero Therapeutics | Bay Area, US | $1.2 bn | NA |
| 485 | Alvotech | Iceland | $1.2 bn | NA |
| 486 | Kanion Pharma | Jiangsu Province, China | $1.1 bn | $545 mn |
| 487 | Hansa BioPharma | Lund, Sweden | $1.1 bn | $0.3 mn |
| 488 | Synthon | Netherlands | $1.1 bn | $316 mn |
| 489 | Innoviva | Bay Area, US | $1.1 bn | $299 mn |
| 490 | Heron Therapeutics | San Diego, US | $1.1 bn | $125 mn |
| 491 | Athenex | New York Area, US | $1.1 bn | $140 mn |
| 492 | SAIDAL | Algeria | $1.1 bn | $313 mn |
| 493 | Faes Farma | Madrid, Spain | $1.1 bn | $458 mn |
| 494 | VTR Bio-tech | Guangdong Province, China | $1.1 bn | $298 mn |
| 495 | Helixsmith | South Korea | $1.1 bn | $4.4 mn |
| 496 | Amarin | New York Area, US | $1.1 bn | $545 mn |
| 497 | Haw Par Corporation | Singapore | $1.1 bn | $130 mn |
| 498 | Sam Chun Dang Pharm | South Korea | $1.1 bn | $152 mn |
| 499 | Rhythm Pharma | Boston Area, US | $1.1 bn | NA |
| 500 | iTeos Therapeutics | Boston Area, US | $1.1 bn | $0 mn |
| 501 | Strides | Bangalore, India | $1.1 bn | $377 mn |
| 502 | Kyorin | Tokyo, Japan | $1.1 bn | $1 bn |
| 503 | Kaken Pharma | Tokyo, Japan | $1.1 bn | $788 mn |
| 504 | Epizyme | Boston Area, US | $1.1 bn | $13 mn |
| 505 | Nurix Therapeutics | Bay Area, US | $1.1 bn | $19 mn |
| 506 | Camurus | Lund, Sweden | $1.1 bn | $22 mn |
| 507 | Arbor Pharma | Atlanta, US | $1.1 bn | $300 mn |
| 508 | Stendhal Pharma | Mexico | $1.1 bn | $300 mn |
| 509 | Chengdu Baiyu | Sichuan Province, China | $1.1 bn | $300 mn |
| 510 | Pulike Biological | Henan Province, China | $1.1 bn | $108 mn |
| 511 | Bharat Biotech | Hyderabad, India | $1.1 bn | $106 mn |
| 512 | Phibro Animal Health | New York Area, US | $1.1 bn | $800 mn |
| 513 | Vianex | Greece | $1.1 bn | $297 mn |
| 514 | Mithra | Belgium | $1.1 bn | $108 mn |
| 515 | LACER | Barcelona, Spain | $1.1 bn | $162 mn |
| 516 | Mayoly Spindler | Paris, France | $1.1 bn | $161 mn |
| 517 | Lummy Pharma | Sichuan Province, China | $1.1 bn | $235 mn |
| 518 | DONGKOOK Pharma | South Korea | $1.1 bn | $433 mn |
| 519 | TECNIMEDE | Portugal | $1 bn | $290 mn |
| 520 | Oscotec | South Korea | $1 bn | $15 mn |
| 521 | Eczacibasi Mac Sanayi | Levent, Turkey | $1 bn | $157 mn |
| 522 | Eurocept | Netherlands | $1 bn | $288 mn |
| 523 | IBI | Aprilia, Italy | $1 bn | $288 mn |
| 524 | Science Sun | Beijing, China | $1 bn | $161 mn |
| 525 | Cristalia | Sao Paolo, Brazil | $1 bn | $287 mn |
| 526 | Pharmicell | South Korea | $1 bn | $23 mn |
| 527 | Sanjin | Guangxi Province, China | $1 bn | $226 mn |
| 528 | Pharmathen | Netherlands | $1 bn | $285 mn |
| 529 | Precigen | Germantown MD, US | $1 bn | $95 mn |
| 530 | KPC | Yunnan Province, China | $1 bn | $1.1 bn |
| 531 | Jiuzhitang | Hubei Province, China | $1 bn | $471 mn |
| 532 | C Labs | Madrid, Spain | $1 bn | $283 mn |
| 533 | Dr. Kade | Berlin, Germany | $1 bn | $154 mn |
| 534 | Generation Bio | Boston Area, US | $1 bn | $0 mn |
| 535 | BioXcel Therapeutics | New York Area, US | $1 bn | NA |
| 536 | Adimmune | Taiwan | $1 bn | $53 mn |
| 537 | Cadila Pharma | Ahmedabad, India | $1 bn | $280 mn |
| 538 | Sana | Seattle, US | $1 bn | NA |
| 539 | AYUMI Pharmaceutical | Tokyo, Japan | $1 bn | $239 mn |
| 540 | Adverum Biotechnologies | Bay Area, US | $1 bn | $0.2 mn |
| 541 | Karyopharm | Boston Area, US | $999 mn | $82 mn |
| 542 | Haixin Group | Shanghai, China | $998.3 mn | $146 mn |
| 543 | Lantheus | Boston Area, US | $997.3 mn | $331 mn |
| 544 | Zogenix | Bay Area, US | $994.7 mn | $4.8 mn |
| 545 | Tris Pharma | Monmouth Junction NJ, US | $990 mn | $150 mn |
| 546 | Zhejiang Int’l Group | Zhejiang Province, China | $989.3 mn | $3.6 bn |
| 547 | Annexon | Bay Area, US | $988.4 mn | $0 mn |
| 548 | Guanhao Biotech | Guangdong Province, China | $985.3 mn | $61 mn |
| 549 | Clovis Oncology | Colorado, U.S. | $983.4 mn | $159 mn |
| 550 | Bottu | Morocco | $981 mn | $272 mn |
| 551 | NGM Biopharmaceuticals | Bay Area, US | $979.7 mn | $96 mn |
| 552 | Normon | Madrid, Spain | $979.2 mn | $272 mn |
| 553 | Zentalis Pharma | New York Area, US | $974 mn | $0 mn |
| 554 | Pharscin Pharma | Sichuan Province, China | $971.8 mn | $115 mn |
| 555 | Oncopeptides | Sweden | $970.7 mn | NA |
| 556 | Huaren Pharma | Shandong Province, China | $968.4 mn | $189 mn |
| 557 | Fudan Forward | Shanghai, China | $964.2 mn | $139 mn |
| 558 | Wockhardt | Mumbai, India | $964.1 mn | $359 mn |
| 559 | Yipinhong Pharma | Guangdong Province, China | $960.8 mn | $214 mn |
| 560 | TerSera Therapeutics | Chicago Area | $957 mn | $145 mn |
| 561 | Eris Lifesciences Limited | Ahmedabad, India | $956.1 mn | $142 mn |
| 562 | Dexa Medica | Medan City, Indonesia | $951 mn | NA |
| 563 | Avidity Biosciences | San Diego, US | $949.2 mn | $4.9 mn |
| 564 | Tonghua Golden-Horse | Jilin Province, China | $943.7 mn | $213 mn |
| 565 | Shandong Shanda | Shandong Province, China | $941.4 mn | $257 mn |
| 566 | Sosei | Tokyo, Japan | $940.1 mn | $66 mn |
| 567 | Beijing Beilu Pharma | Beijing, China | $937.2 mn | $111 mn |
| 568 | Amphastar Pharma | Los Angeles, US | $936.9 mn | $334 mn |
| 569 | Takata Pharmaceutical | Saitama, Japan | $936 mn | NA |
| 570 | Tabuk Pharma | Riyadh, Saudi Arabia | $936 mn | $260 mn |
| 571 | Omeros | Seattle, US | $935 mn | $100 mn |
| 572 | Healios | Tokyo, Japan | $932.4 mn | $2.3 mn |
| 573 | Nippon Kayaku Pharma | Tokyo, Japan | $928 mn | $444mm |
| 574 | Kiniksa Pharma | Boston Area, US | $926.3 mn | NA |
| 575 | Boston Scientific Pharma | Boston Area, US | $924 mn | $140 mn |
| 576 | Renhe | Jiangxi Province, China | $921.5 mn | $577 mn |
| 577 | Applied Molecular Transp | Bay Area, US | $920.5 mn | $0 mn |
| 578 | Tai’an Tang Pharma | Shanghai, China | $918.6 mn | $547 mn |
| 579 | Arcus Biosciences | Bay Area, US | $914.1 mn | $15 mn |
| 580 | Arcturus Therapeutics | San Diego, US | $910.4 mn | $11 mn |
| 581 | Vetoquinol | Paris, France | $906.1 mn | $444 mn |
| 582 | JW Holdings | South Korea | $905.5 mn | $618 mn |
| 583 | Esperion | Ann Arbor, MI, US | $904.9 mn | $216 mn |
| 584 | Apsen | Sao Paolo, Brazil | $900 mn | $250 mn |
| 585 | Dexcel Pharma | Israel | $900 mn | $250 mn |
| 586 | Agenus | Boston Area, US | $897.9 mn | $96 mn |
| 587 | J. B. Chemicals | Mumbai, India | $897.5 mn | $245 mn |
| 588 | Jingxin Pharm | Zhejiang Province, China | $895.1 mn | $485 mn |
| 589 | Intellia Therapeutics | Boston Area, US | $894.5 mn | $50 mn |
| 590 | Mochida | Tokyo, Japan | $892.1 mn | $952 mn |
| 591 | Osiris | Columbia MD, US | $888.3 mn | $134 mn |
| 592 | SKK | Tokyo, Japan | $887.3 mn | $424 mn |
| 593 | Stoke Therapeutics, Inc. | Boston Area, US | $887 mn | NA |
| 594 | Ampharco U.S.A. | Nhon Trach, Vietnam | $885.5 mn | $245 mn |
| 595 | Oxford BioMedica | Oxford, UK | $885.1 mn | $81 mn |
| 596 | Shanghai Furen | Shanghai, China | $884.9 mn | $529 mn |
| 597 | Binex | South Korea | $884.1 mn | $107 mn |
| 598 | Daewoong | South Korea | $884 mn | $890 mn |
| 599 | Zhendong Pharma | Shanxi Province, China | $881.9 mn | $622 mn |
| 600 | Sangamo Therapeutics | Bay Area, US | $881.8 mn | $111 mn |
| 601 | TaiMed Biologics | Taiwan | $878.8 mn | $28 mn |
| 602 | PharmaEssentia | Taiwan | $877.2 mn | $11 mn |
| 603 | Jiangzhong Pharma | Jiangxi Province, China | $870.6 mn | $349 mn |
| 604 | Pharm-Sintez | Moscow, Russia | $865.8 mn | $240 mn |
| 605 | Dong-A Socio | South Korea | $860 mn | $659 mn |
| 606 | Jingfeng Pharma | Shanghai China | $858 mn | $172 mn |
| 607 | Jiudian Pharma | Changsha, China | $846.8 mn | $126 mn |
| 608 | Incepta Pharma | Bangladesh | $843.7 mn | $234 mn |
| 609 | Black Diamond Tx | Boston Area, US | $842.4 mn | NA |
| 610 | Immunocore | Oxford, UK | $839.4 mn | NA |
| 611 | Bosnalijek | Bosnia-Herzegovina | $837.7 mn | $232 mn |
| 612 | Bilim Pharmaceuticals | Turkey | $836.2 mn | $232 mn |
| 613 | Qianhong Biopharma | Jiangsu Province, China | $835.6 mn | $210 mn |
| 614 | Akorn | Chicago Area | $833 mn | $682 mn |
| 615 | Supernus | Rockville MD, US | $832.6 mn | $424 mn |
| 616 | Jinhe Biotech | Liaoning Province, China | $830.8 mn | $254 mn |
| 617 | Repare Therapeutics | Toronto, Canada | $830.4 mn | $0 mn |
| 618 | REGENXBIO | Rockville MD, US | $828.4 mn | $60 mn |
| 619 | Poseida Therapeutics | San Diego, US | $828.2 mn | $0 mn |
| 620 | Atara Biotherapeutics | Bay Area, US | $827.8 mn | NA |
| 621 | Beijing Tong Ren Tang | Hebei Province, China | $825.3 mn | $600 mn |
| 622 | Tong Ren Tang Tech | Beijing, China | $825.3 mn | $600 mn |
| 623 | Lingrui Pharma | Henan Province, China | $824.3 mn | $306 mn |
| 624 | Xinhua Pharm | Shandong Province, China | $823.7 mn | $816 mn |
| 625 | Cstone Pharma | Jiangsu Province, China | $822.9 mn | $3.2 mn |
| 626 | Chong Kun Dang Pharm | South Korea | $821.1 mn | $662 mn |
| 627 | Yoshindo | Toyama, Japan | $817 mn | $391 mn |
| 628 | Atea Pharma | Boston Area, US | $817 mn | NA |
| 629 | SanBio | Tokyo, Japan | $814 mn | $0.1 mn |
| 630 | Nihon Chouzai Generics | Tokyo, Japan | $808.8 mn | $2.5 bn |
| 631 | Laboratoires Brothier | Fontevraud-l’Abbaye, France | $805.8 mn | $223 mn |
| 632 | Bioiberica | Barcelona, Spain | $803.7 mn | $223 mn |
| 633 | Arvinas | New York Area, US | $802 mn | $46 mn |
| 634 | Jolly Pharmaceutical | Zhejiang Province, China | $801.4 mn | $134 mn |
| 635 | Pharmaceutical Associates | Washington DC Area | $800 mn | $100 mn |
| 636 | Collegium Pharmaceutical | Boston Area, US | $797.7 mn | $301 mn |
| 637 | Komipharm International | South Korea | $797.6 mn | $31 mn |
| 638 | Guidotti | Pisa, Italy | $797.1 mn | $221 mn |
| 639 | AOP Orphan | Austria | $794.3 mn | $120 mn |
| 640 | Zdrowie | Poland | $793 mn | $220 mn |
| 641 | Farmigea | Pisa, Italy | $790.2 mn | $119 mn |
| 642 | Vectura | London, United Kingdom | $784.2 mn | $218 mn |
| 643 | Keros Therapeutics | Boston Area, US | $782.5 mn | $5 mn |
| 644 | The GPO | Thailand | $779.7 mn | $216 mn |
| 645 | Tolmar / Tecnofarma | Colombia | $778.8 mn | $118 mn |
| 646 | Eusa Pharma | London, United Kingdom | $778.8 mn | $87 mn |
| 647 | Ji Yao Holding | Jilin Province, China | $774 mn | $9.5 bn |
| 648 | Laboratoire Renaudin | Itxassou, France | $772 mn | $214 mn |
| 649 | Lannett | Philadelphia Area, US | $771.9 mn | $545 mn |
| 650 | Yibai Pharmaceutical | Guizhou, China | $770 mn | $456 mn |
| 651 | BioArctic | Norway | $768.9 mn | $9.8 mn |
| 652 | Wohua Pharma | Shandong Province, China | $765.8 mn | $131 mn |
| 653 | Vericel | Boston Area, US | $765.7 mn | $116 mn |
| 654 | Havea Group | Bouffere, France | $764.6 mn | $212 mn |
| 655 | Prati, Donaduzzi & Cia. | Toledo, Brazil | $763.2 mn | $212 mn |
| 656 | Lionco Pharma | Zhejiang Province, China | $762.4 mn | $180 mn |
| 657 | Innovis Pharma | Greece | $760.3 mn | $211 mn |
| 658 | RAPT Therapeutics | Bay Area, US | $756.9 mn | $2.2 mn |
| 659 | Farmak | Kiev, Ukraine | $756 mn | $236 mn |
| 660 | Medis o.o.o. | Llubjana, Slovenia | $755.4 mn | $114 mn |
| 661 | Retrophin | San Diego, US | $754.5 mn | $187 mn |
| 662 | Kocak Farma | Istanbul, Turkey | $752.4 mn | $209 mn |
| 663 | Clinuvel Pharma | Zurich, Switzerland | $751.1 mn | $22 mn |
| 664 | VBI Vaccines | Boston Area, US | $749.5 mn | $1.8 mn |
| 665 | Replimune | Boston Area, US | $745 mn | NA |
| 666 | Pharming | Netherlands | $743.8 mn | $202 mn |
| 667 | Valenta Pharma | Moscow, Russia | $743.4 mn | $206 mn |
| 668 | Inhibrx | San Diego, US | $743.1 mn | NA |
| 669 | Desitin | Hamburg, Germany | $742.5 mn | $112 mn |
| 670 | CrystalGenomics | South Korea | $740.2 mn | $77 mn |
| 671 | FDC | Mumbai, India | $739.3 mn | $173 mn |
| 672 | Kai Bao Pharma | Shanghai, China | $739.1 mn | $156 mn |
| 673 | Blau Farmaceutica | Cotia, Brazil | $738.7 mn | $205 mn |
| 674 | Fatro | Milan, Italy | $735.9 mn | $111 mn |
| 675 | Arcutis Biotherapeutics | Los Angeles, US | $735.7 mn | NA |
| 676 | NantKwest | Los Angeles, US | $735.4 mn | NA |
| 677 | Translate Bio | Lexington, MA | $734.3 mn | $26 mn |
| 678 | SIFI | Sicily, Italy | $731.1 mn | $203 mn |
| 679 | Liminal BioSciences | Quebec, Canada | $729.1 mn | NA |
| 680 | Jiangsu Sihuan Bio | Jiangsu Province, China | $729 mn | $68 mn |
| 681 | Geropharm | Russia | $727.2 mn | $72 mn |
| 682 | Maruishi Pharma | Osaka, Japan | $726.3 mn | $347 mn |
| 683 | Currax Pharma | New York Area, US | $726 mn | $110 mn |
| 684 | Yabao Pharmaceutical | Shanxi Province, China | $722 mn | $370 mn |
| 685 | Exela Pharma | Lenoir, NC | $720 mn | $200 mn |
| 686 | Nippon Zoki | Osaka, Japan | $718.9 mn | $199 mn |
| 687 | Hengkang Medical | Sichuan Province, China | $716.6 mn | $437 mn |
| 688 | Senju Pharma | Osaka, Japan | $710.6 mn | $401 mn |
| 689 | Phathom Pharma | New York Area, US | $710.4 mn | NA |
| 690 | Cosunter | Fujian Province, China | $709.8 mn | $52 mn |
| 691 | Farabi Pharma | Iran | $709.2 mn | $197 mn |
| 692 | Teuto | Goias, Brazil | $705.6 mn | $196 mn |
| 693 | Acme Pharmaceuticals | Bangladesh | $704.5 mn | $195 mn |
| 694 | Julphar | United Arab Emirates | $703.8 mn | $102 mn |
| 695 | AB Science | Paris, France | $703.1 mn | $1.7 mn |
| 696 | Jinghua Pharma | Jiangsu Province, China | $698.9 mn | $159 mn |
| 697 | Dicerna Pharma | Boston Area, US | $692.1 mn | $89 mn |
| 698 | Boryung Pharma | South Korea | $689.9 mn | $456 mn |
| 699 | Beximco Pharma | Bangladesh | $689.9 mn | $295 mn |
| 700 | MiMedx | Atlanta, US | $687.8 mn | $280 mn |
| 701 | Staidson | Beijing, China | $686.8 mn | $68 mn |
| 702 | Emisphere Technologies | New York Area, US | $675.7 mn | $1 mn |
| 703 | Konruns Pharma | Beijing, China | $673.8 mn | $123 mn |
| 704 | Exir Pharmaceutical | Iran | $671 mn | $186 mn |
| 705 | DOC Generici | Milan, Italy | $669.6 mn | $186 mn |
| 706 | Radius | Boston Area, US | $669 mn | $200 mn |
| 707 | SillaJen | South Korea | $667.8 mn | $1.9 mn |
| 708 | Basilea | Basel, Switzerland | $667.6 mn | $148 mn |
| 709 | Vaxart | Bay Area, US | $667.3 mn | $7.7 mn |
| 710 | Pharmasyntez | Irkutsk, Russia | $666 mn | $185 mn |
| 711 | Cisen Pharmaceutical | Shandong Province, China | $663 mn | $539 mn |
| 712 | Tchaikapharma | Bulgaria | $662.3 mn | NA |
| 713 | MedDay Pharma | Paris, France | $660 mn | NA |
| 714 | Pharmacosmos | Copenhagen, Denmark | $660 mn | $100 mn |
| 715 | Eumedica | Belgium | $660 mn | $100 mn |
| 716 | Shilpa | Bangalore, India | $658.2 mn | $128 mn |
| 717 | Alector | Bay Area, US | $655.1 mn | $19 mn |
| 718 | Senhwa | Taiwan | $653.1 mn | NA |
| 719 | Dr. August Wolff | Bielefield, Germany | $649.5 mn | $98 mn |
| 720 | Cellectis | Paris, France | $648.2 mn | $73 mn |
| 721 | Kissei | Matsumoto, Japan | $647.1 mn | $586 mn |
| 722 | SPARC | Mumbai, India | $644.4 mn | $32 mn |
| 723 | Nobel | Turkey | $644.4 mn | $179 mn |
| 724 | Indofarma | Indonesia | $642.9 mn | $99 mn |
| 725 | Medigen Vaccine | Taiwan | $639.9 mn | NA |
| 726 | Flexion Therapeutics | Boston Area, US | $639.8 mn | $81 mn |
| 727 | Laboratoires Genevrier | Lyon, France | $639.4 mn | $96 mn |
| 728 | Kadmon | New York Area, US | $632.1 mn | $11 mn |
| 729 | Mayne Pharma | Melbourne, Australia | $624.6 mn | $315 mn |
| 730 | Morphic Therapeutics | Boston Area, US | $622.4 mn | $18 mn |
| 731 | Ozon Pharmaceuticals | Russia | $622 mn | $172 mn |
| 732 | OBI Pharma | Taiwan | $617.4 mn | $2 mn |
| 733 | Albireo Pharma | Boston Area, US | $616.9 mn | $11 mn |
| 734 | Sinovac | Beijing, China | $615 mn | $213 mn |
| 735 | Krystal Biotech | Pittsburgh Area, US | $614.6 mn | NA |
| 736 | Provention Bio, Inc. | New York Area, US | $614 mn | NA |
| 737 | ZENOAQ | Tokyo, Japan | $612.3 mn | $293 mn |
| 738 | Alora Pharma | Atlanta, US | $612 mn | $170 mn |
| 739 | Pliant Therapeutics | Bay Area, US | $608.7 mn | $89 mn |
| 740 | Sciclone | Shanghai, China | $605 mn | NA |
| 741 | Dynavax | Bay Area, US | $604.1 mn | $34 mn |
| 742 | Handok | South Korea | $602.5 mn | $405 mn |
| 743 | BioCryst | North Carolina, US | $602.3 mn | $49 mn |
| 744 | Weixinkang Medicine | Lhasa, Tibet, China | $601.2 mn | $95 mn |
| 745 | PKU HealthCare Corp. | Sichuan Province, China | $600.2 mn | $311 mn |
| 746 | Inozyme Pharma | Boston Area, US | $597.4 mn | $0 mn |
| 747 | Protagonist Therapeutics | Bay Area, US | $594.4 mn | $16 mn |
| 748 | HRA Pharma | New York Area, US | $594 mn | $90 mn |
| 749 | Molecular Templates | Austin, Texas | $592.7 mn | $20 mn |
| 750 | Boiron | Lyon, France | $590.4 mn | $623 mn |
| 751 | Nephron Pharma | West Columbia, SC | $589.3 mn | $163 mn |
| 752 | CCM Duopharma Biotech | Malaysia | $586.4 mn | $135 mn |
| 753 | Hiteck Biological Pharma | Wuhan, China | $585.7 mn | $69 mn |
| 754 | Deva Holding | Turkey | $585.4 mn | $230 mn |
| 755 | Laboraoires Majorelle | Paris, France | $583.2 mn | $30 mn |
| 756 | SOHO Global Healthcare | Indonesia | $578.8 mn | |
| 757 | Teikoku Senyaku | Higashikagawa, Japan | $576.8 mn | $276 mn |
| 758 | Alliance Pharma | London, United Kingdom | $571.8 mn | $162 mn |
| 759 | Caplin Point Laboratories | Chennai, India | $568.7 mn | $120 mn |
| 760 | Nativa | Russia | $567.3 mn | $157 mn |
| 761 | Cara Therapeutics | New York Area, US | $565.9 mn | $24 mn |
| 762 | Grupo Medinfar | Portugal | $565.4 mn | $157 mn |
| 763 | Gongwin Biopharm | Taiwan | $564.9 mn | NA |
| 764 | Cassiopea S.p.A. | Milan, Italy | $564.7 mn | $0.7 mn |
| 765 | Bath ASU | London, United Kingdom | $564.5 mn | $156 mn |
| 766 | Frequency Therapeutics | Boston Area, US | $563.9 mn | $44 mn |
| 767 | Foci Pharmaceutical | Gansu Province, China | $562.6 mn | $91 mn |
| 768 | DEMO | Greece | $561.5 mn | $155 mn |
| 769 | Newbridge Pharma | United Arab Emirates | $561 mn | $85 mn |
| 770 | Inibsa | Barcelona, Spain | $560.6 mn | $155 mn |
| 771 | Taloph | Henan Province, China | $559 mn | $193 mn |
| 772 | Famar | Greece | $557.3 mn | $154 mn |
| 773 | Akouos Therapeutics | Boston Area, US | $557.1 mn | $0 mn |
| 774 | TTY Biopharm | Taiwan | $555.9 mn | $144 mn |
| 775 | Amryt Pharma | Ireland | $554.4 mn | NA |
| 776 | Intersect ENT | Bay Area, US | $552.9 mn | $85 mn |
| 777 | HAL Allergy | Netherlands | $552.4 mn | $83 mn |
| 778 | Hansen Pharm | Hubei Province, China | $551.2 mn | $110 mn |
| 779 | Biosidus | Argentina | $551 mn | $54 mn |
| 780 | Northwest Bio | Bethesda MD, US | $548 mn | $2 mn |
| 781 | Farmfirma Soteks | Russia | $544.6 mn | $151 mn |
| 782 | Jianmin Group | Hubei Province, China | $542.5 mn | $304 mn |
| 783 | Cau Technology | Guangdong Province, China | $541.9 mn | $7.6 mn |
| 784 | WAVE Life Sciences | Boston Area, US | $541.1 mn | $12 mn |
| 785 | Elpen Pharma | Greece | $540 mn | $150 mn |
| 786 | Petrovax | Russia | $538.5 mn | $149 mn |
| 787 | Autolus Therapeutics | London, United Kingdom | $537.7 mn | $1.2 mn |
| 788 | Berlin Pharma | Thailand | $536.4 mn | $149 mn |
| 789 | Recursion Pharma | Salt City, Utah | $529 mn | NA |
| 790 | Saol Therapeutics | Atlanta, US | $528 mn | $80 mn |
| 791 | Sito Bio | Shandong Province, China | $527.8 mn | $124 mn |
| 792 | TaiGen | Taiwan | $526.2 mn | $0.7 mn |
| 793 | Taiwan Biotech | Taiwan | $525.4 mn | $145 mn |
| 794 | ImmunoGen | Boston Area, US | $525 mn | $86 mn |
| 795 | Kyowa Pharmaceutical | Osaka, Japan | $525 million | $230 mm |
| 796 | JGL | Croatia | $523.5 mn | $145 mn |
| 797 | Lepu Bio | Shanghai, China | $523 mn | NA |
| 798 | Honz Pharma | Guangdong Province, China | $521.8 mn | $127 mn |
| 799 | Getz Pharma | Pakistan | $520.2 mn | $144 mn |
| 800 | ANI Pharmaceuticals | Minnesota, US | $519.6 mn | $197 mn |
| 801 | PharmaResearch Prod. | South Korea | $519.4 mn | $76 mn |
| 802 | Yakult Pharma Segment | Tokyo, Japan | $519 mn | NA |
| 803 | Freeline Therapeutics | Stevenage, UK | $518.3 mn | $0 mn |
| 804 | Gossamer Bio | San Diego, US | $516.6 mn | NA |
| 805 | Shenqi Pharmaceutical | Guizhou, China | $516.2 mn | $262 mn |
| 806 | DHG Pharma | Can Tho, Vietnam | $516 mn | $164 mn |
| 807 | Valneva | Lyon, France | $515.7 mn | $134 mn |
| 808 | Ocular Therapeutix | Boston Area, US | $515.5 mn | $7.2 mn |
| 809 | Hua Medicine | Hong Kong | $513 mn | $3.1 mn |
| 810 | Enanta | Boston Area, US | $512.2 mn | $150 mn |
| 811 | Rana Pharm | South Korea | $511.2 mn | $142 mn |
| 812 | Cosar Pharmaceutical | Iran | $511.2 mn | $142 mn |
| 813 | Aerie Pharmaceuticals | North Carolina, US | $510.2 mn | $81 mn |
| 814 | Organogenesis | Boston Area, US | $508.1 mn | $269 mn |
| 815 | TherapeuticsMD | Boca Raton, FL | $506.2 mn | $62 mn |
| 816 | Consilient Health | Ireland | $506.2 mn | $76 mn |
| 817 | Huons | South Korea | $505.1 mn | $402 mn |
| 818 | SIGA Technologies | New York Area, US | $504.9 mn | $55 mn |
| 819 | Syndax Pharmaceuticals | Boston Area, US | $504.6 mn | $1.5 mn |
| 820 | Corium | Bay Area, US | $504 mn | NA |
| 821 | Genor Biopharma | Shanghai, China | $503 million | NA |
| 822 | IE Ulagay | Turkey | $501.4 mn | $139 mn |
| 823 | Ambiopharm | North August, SC, US | $500 mn | NA |
| 824 | Odin Pharmaceuticals | Somerset NJ | $500 mn | $80 mn |
| 825 | NKMax | Los Angeles, US | $496.5 mn | $7.6 mn |
| 826 | Teyi Pharmaceutical Group | Guangdong Province, China | $496 mn | $105 mn |
| 827 | Jeil | South Korea | $495.1 mn | $624 mn |
| 828 | TCR2 Therapeutics | Boston Area, US | $494.3 mn | NA |
| 829 | Celon Pharma | Poland | $494.2 mn | $25 mn |
| 830 | Hicin | Jiangsu Province, China | $493.8 mn | $119 mn |
| 831 | Fengyuan Pharmaceutical | Anhui Province, China | $493.3 mn | $459 mn |
| 832 | kaleo | Richmond, Virginia | $492.2 mn | $125 mn |
| 833 | Aprea Therapeutics, Inc. | Boston Area, US | $491.8 mn | NA |
| 834 | AMAG Pharma | Boston Area, US | $489.7 mn | $297 mn |
| 835 | Aprogen Pharmaceuticals | South Korea | $486.4 mn | $45 mn |
| 836 | Pandion Therapeutics | Boston Area, US | $484.9 mn | $4.9 mn |
| 837 | Green Cross Cell | South Korea | $483 mn | $31 mn |
| 838 | Arterium | Kiev, Ukraine | $482.7 mn | $134 mn |
| 839 | Sopharma | Bulgaria | $480.7 mn | $775 mn |
| 840 | OM Pharm | Zurich, Switzerland | $478 mn | $101 mn |
| 841 | ZIOPHARM Oncology | Boston Area, US | $476.2 mn | NA |
| 842 | ASKA Pharmaceutical | Tokyo, Japan | $474.7 mn | $484 mn |
| 843 | Dongwha Pharm | South Korea | $473.6 mn | $245 mn |
| 844 | Relmada Therapeutics | New York, NY | $471.4 mn | NA |
| 845 | YungShin Global | Taiwan | $470.4 mn | $280 mn |
| 846 | Vertice Pharma | New York Area, US | $468 mn | $130 mn |
| 847 | Farmac-Zabban | Bologna, Italy | $467.8 mn | $129 mn |
| 848 | MannKind | Los Angeles, US | $466 mn | $61 mn |
| 849 | Ansun Biopharma | San Diego, US | $466 million | NA |
| 850 | BiondVax Pharmaceuticals | Israel | $464.8 mn | NA |
| 851 | Amlyx | Boston Area, US | $464 million | NA |
| 852 | XOMA | Bay Area, US | $463.8 mn | $10 mn |
| 853 | Codupha | Ho Chi Minh, Vietnam | $463.6 mn | $128 mn |
| 854 | Yatai Pharma | Zhejiang Province, China | $463.4 mn | $55 mn |
| 855 | SERB | Belgium | $463.3 mn | $70 mn |
| 856 | FangSheng Pharma | Hubei Province, China | $462.8 mn | $160 mn |
| 857 | CMG Pharma | South Korea | $462.5 mn | $49 mn |
| 858 | Romark | Tampa, FL | $462 mn | $70 mn |
| 859 | Reig Jofre | Barcelona, Spain | $461.8 mn | $257 mn |
| 860 | Poly Pharmaceuticals | Huntsville, AL | $460.8 mn | $128 mn |
| 861 | Lianhuan Pharma | Jiangsu Province, China | $459.7 mn | $191 mn |
| 862 | Eagle Pharma | New York Area, US | $458.4 mn | $177 mn |
| 863 | Odonate Therapeutics | San Diego, US | $456.5 mn | NA |
| 864 | Qianjin Pharmaceutical | Hubei Province, China | $455.6 mn | $497 mn |
| 865 | Cue Biopharma | Boston Area, US | $454.7 mn | $4 mn |
| 866 | Longjin Pharmaceutical | Yunnan Province, China | $452.3 mn | $34 mn |
| 867 | ORIC Pharma | Bay Area, US | $451.9 mn | NA |
| 868 | Jiaying Pharmaceutical | Guangdong Province, China | $451.6 mn | $69 mn |
| 869 | Hanlim | South Korea | $448.5 mn | $124 mn |
| 870 | Daito Pharmaceutical | Toyama, Japan | $448.3 mn | $417 mn |
| 871 | Guangji Pharmaceutical | Hubei Province, China | $448.2 mn | $100 mn |
| 872 | Silence Therapeutics | London, United Kingdom | $447.1 mn | $1.7 mn |
| 873 | Bristol Laboratories | London, United Kingdom | $445.2 mn | $123 mn |
| 874 | Pengqi Technology Devp | Shanghai China | $443.1 mn | $121 mn |
| 875 | Soria Natural | Garray, Spain | $442.7 mn | $122 mn |
| 876 | MIP Group | Blieskastel, Germany | $442.4 mn | $122 mn |
| 877 | Osmotica | New York Area, US | $440.1 mn | $211 mn |
| 878 | SALVAT | Barcelona, Spain | $440 mn | $66 mn |
| 879 | Jacobson Pharma | Hong Kong | $439.4 mn | $202 mn |
| 880 | Indivior | Richmond, Virginia | $439.4 mn | $634 mn |
| 881 | Eutilex | South Korea | $439.1 mn | $0.8 mn |
| 882 | 89bio | Bay Area, US | $439.1 mn | NA |
| 883 | Aptose Biosciences | Toronto Area, Canada | $438.8 mn | NA |
| 884 | Pharma Foods International | Kyoto, Japan | $437.7 mn | $145 mn |
| 885 | Anika Therapeutics | Boston Area, US | $437 mn | $125 mn |
| 886 | Starpharma | Melbourne, Australia | $435.8 mn | $4.5 mn |
| 887 | Lisheng Pharma | Hebei Province, China | $435.1 mn | $194 mn |
| 888 | Taihe Health Technology | Sichuan Province, China | $433.3 mn | $101 mn |
| 889 | Farma de Colombia SAS | Colombia | $432 mn | $120 mn |
| 890 | Brainstorm Cell Tx | New York Area, US | $431.7 mn | NA |
| 891 | RedHill Biopharma | Tel-Aviv, Israel | $431.1 mn | $24 mn |
| 892 | Spectrum | Las Vegas, NV | $430.1 mn | NA |
| 893 | Anterogen | South Korea | $428.6 mn | $3.4 mn |
| 894 | Tricida | Bay Area, US | $428 mn | NA |
| 895 | Panlong Pharmaceutical | Shangluo, China | $426 mn | $64 mn |
| 896 | Alter Pharma | Belgium | $424.8 mn | $118 mn |
| 897 | Passage Bio, Inc. | Philadelphia Area, US | $423.4 mn | NA |
| 898 | Molecular Partners | Zurich, Switzerland | $422.3 mn | $15 mn |
| 899 | Caregen | South Korea | $422.2 mn | $53 mn |
| 900 | Ferndale Pharma Group | Michigan, US | $421.7 mn | $63 mn |
| 901 | Franco-Indian (FIPPL) | Mumbai, India | $420.7 mn | $116 mn |
| 902 | La borate Pharmaceuticals | Haryana, India | $420.1 mn | $116 mn |
| 903 | Qianjiang Pharmaceutical | Hubei Province, China | $418.5 mn | $111 mn |
| 904 | Highland Therapeutics | Toronto Area, Canada | $418 mn | NA |
| 905 | Molteni | Florence, Italy | $417.7 mn | $63 mn |
| 906 | TOA EIYO | Tokyo, Japan | $416 mn | $131 mn |
| 907 | Syros Pharma | Boston Area, US | $414.3 mn | $6.6 mn |
| 908 | Medigen | Taiwan | $413.1 mn | $18 mn |
| 909 | Beyond Spring Pharma | New York Area, US | $412.5 mn | NA |
| 910 | Theragen Etex | South Korea | $412.4 mn | $114 mn |
| 911 | Calliditas Therapeutics | Sweden | $412.2 mn | $5 mn |
| 912 | Vyera Therapeutics | New York Area, US | $411.8 mn | $62 mn |
| 913 | Neoleukin Therapeutics | Seattle, US | $411.6 mn | NA |
| 914 | Daewon Pharm | South Korea | $410.9 mn | $265 mn |
| 915 | HLS Therapeutics | Toronto Area, Canada | $409.8 mn | $53 mn |
| 916 | Puma Biotechnology | Los Angeles, US | $409.2 mn | $241 mn |
| 917 | Kymab | Cambridge, UK | $408.5 mn | NA |
| 918 | Seikagaku | Tokyo, Japan | $408.2 mn | $259 mn |
| 919 | Diachem | Bergamo, Italy | $408.2 mn | $113 mn |
| 920 | Adcock Ingram | South Africa | $407.5 mn | $423 mn |
| 921 | Applied Therapeutics, Inc. | New York Area, US | $404.7 mn | NA |
| 922 | Instituto Vital Brazil | Rio de Janeiro, Brazil | $403.3 mn | $112 mn |
| 923 | iNtRON Biotechnology | South Korea | $403.2 mn | $25 mn |
| 924 | Moehs | Barcelona, Spain | $401.8 mn | $111 mn |
| 925 | US WorldMeds | Louisville, KY, US | $400 mn | NA |
| 926 | Yisheng Pharma | Jilin Province, China | $398.9 mn | $128 mn |
| 927 | BioDelivery Sciences | North Carolina, US | $397.8 mn | $136 mn |
| 928 | Cosette Pharma | New York Area, US | $396 mn | $110 mn |
| 929 | Aft Pharm | New Zealand | $395.4 mn | $62 mn |
| 930 | Synmosa Biopharma | Taiwan | $393.9 mn | $97 mn |
| 931 | Ardelyx | Bay Area, US | $391.9 mn | $8.3 mn |
| 932 | Bluefish Pharmaceuticals | Stockholm, Sweden | $391.7 mn | $108 mn |
| 933 | Furui | Beijing, China | $390.6 mn | $114 mn |
| 934 | G1 Therapeutics | North Carolina, US | $390.4 mn | $2.1 mn |
| 935 | Blue Pharma-Industria | Portugal | $389.2 mn | $108 mn |
| 936 | Belupo | Croatia | $385.2 mn | $107 mn |
| 937 | Ohara Pharma | Tokyo, Japan | $384.3 mn | $183 mn |
| 938 | Mirum Pharmaceuticals | Bay Area, US | $384.2 mn | NA |
| 939 | Cellular Biomedicine | Bay Area, US | $382.3 mn | $0.2 mn |
| 940 | Sihuan Pharma | Beijing, China | $382.2 mn | $323 mn |
| 941 | Neutec Ilac | Turkey | $378.3 mn | $105 mn |
| 942 | Ildong Pharmaceutical | South Korea | $378 mn | $467 mn |
| 943 | AC Immune | Lausanne, Switzerland | $376.4 mn | $50 mn |
| 944 | Lee’s Pharmaceutical | Hong Kong | $376 mn | $150 mn |
| 945 | VIVUS | Bay Area, US | $375.5 mn | $56 mn |
| 946 | Scholar Rock Holding | Boston Area, US | $371.4 mn | $21 mn |
| 947 | Therabel Pharma | Netherlands | $370 mn | NA |
| 948 | Humanigen | Bay Area, US | $369.6 mn | NA |
| 949 | Fortress Biotech | New York Area, US | $369.5 mn | $43 mn |
| 950 | Savior Lifetec | Taiwan | $368.7 mn | $52 mn |
| 951 | Assembly Biosciences | Bay Area, US | $368.2 mn | $52 mn |
| 952 | Rigel Pharmaceuticals | Bay Area, US | $367.8 mn | $108 mn |
| 953 | Kala Pharmaceuticals | Boston Area, US | $367.7 mn | $4.5 mn |
| 954 | Materia Medica | Moscow, Russia | $367.2 mn | $102 mn |
| 955 | Fuji Pharma | Tokyo, Japan | $365.8 mn | $314 mn |
| 956 | Ovid Therapeutics | New York Area, US | $364.7 mn | NA |
| 957 | TransMedics Group | Andover, MA | $363.1 mn | $24 mn |
| 958 | Kintor Pharma | Jiangsu Province, China | $362.5 mn | $0 mn |
| 959 | Urovant Sciences | Irvine, CA | $362.3 mn | $0 mn |
| 960 | Darnitsa | Ukraine | $360 mn | $100 mn |
| 961 | MS Pharma – El Kendi | Algeria | $360 mn | $100 mn |
| 962 | Ascendis Health | South Africa | $359.3 mn | $427 mn |
| 963 | Kolon Life Sciences | South Korea | $358.9 mn | $128 mn |
| 964 | Nissin | Tendo, Japan | $358.1 mn | $171 mn |
| 965 | Indoco | Mumbai, India | $357.3 mn | $149 mn |
| 966 | Atreca | Bay Area, US | $357 mn | NA |
| 967 | Alium Group | Russia | $355.6 mn | $98 mn |
| 968 | The Searle Company | Pakistan | $355.3 mn | $98 mn |
| 969 | Kwang Dong Pharma | South Korea | $353.9 mn | $1 bn |
| 970 | Jinling Pharma | Jiangsu Province, China | $353.7 mn | $338 mn |
| 971 | Verona Pharma | London, United Kingdom | $351.5 mn | NA |
| 972 | EIPICO | Egypt | $351.5 mn | $192 mn |
| 973 | HNSP | Hainan Province, China | $350.6 mn | $40 mn |
| 974 | AVROBIO | Boston Area, US | $350.5 mn | NA |
| 975 | Checkmate Pharma | Boston Area, US | $350.4 mn | NA |
| 976 | Xinguan Pharmaceutical | Zhejiang Province, China | $350.2 mn | $39 mn |
| 977 | Flynn Pharma | London, United Kingdom | $349.9 mn | $59 mn |
| 978 | Tanvex | Taiwan | $349.2 mn | NA |
| 979 | C&Y Group | Shanxi Province, China | $347.7 mn | $137 mn |
| 980 | ACME Laboratories | Bangladesh | $347.5 mn | $213 mn |
| 981 | TAEJOON PHARM | South Korea | $347 mn | $96 mn |
| 982 | Farmabase | Jaguariuna, Brazil | $346.5 mn | $52 mn |
| 983 | Xbiotech | Austin, TX, US | $345.1 mn | $28 mn |
| 984 | Apex Healthcare | Malaysia | $343.6 mn | $167 mn |
| 985 | Oyster Point Pharma | Princeton, NJ, US | $342.2 mn | NA |
| 986 | Athersys, Inc. | Cleveland, Ohio | $341.7 mn | $0 mn |
| 987 | Paratek | Boston Area, US | $341.7 mn | $30 mn |
| 988 | PBF | Taiwan | $340.3 mn | $50 mn |
| 989 | Grupo Azevedos | Portugal | $339.8 mn | $94 mn |
| 990 | Centaur Pharma | Mumbai, India | $338.8 mn | $94 mn |
| 991 | SOTH EMA | Morocco | $338.4 mn | $178 mn |
| 992 | Orchard Therapeutics | London, United Kingdom | $338.4 mn | $3.1 mn |
| 993 | Cantargia | Lund, Sweden | $338.4 mn | NA |
| 994 | Tiansheng Pharma | Jiangsu Province, China | $337.8 mn | $199 mn |
| 995 | Tiziana Life Sciences | London, United Kingdom | $337.3 mn | NA |
| 996 | Aestura | South Korea | $336.9 mn | $93 mn |
| 997 | UroGen Pharma | New York Area, US | $336.5 mn | $0.3 mn |
| 998 | Telix | Melbourne, Australia | $336.4 mn | NA |
| 999 | China Chemical & Pharma | Taiwan | $336 mn | $272 mn |
| 1000 | Shapuaisi Pharma | Zhejiang Province, China | $335.5 mn | $55 mn |
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